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Modulation Of The Nf-Κb Activation Pathway By Phycocyanobilin From Spirulina Platensis: An In Silico Study, Febriana Catur Iswanti, Hastuti Handayani S Purba, Ani Retno Prijanti, Fadilah Fadilah, Linda Herlina, Reni Paramita

Makara Journal of Science

Several studies have predicted the molecular interactions of the active ingredient of Spirulina platensis as an anti-inflammatory compound. However, these interaction studies did not review the modulation of the NF-κB activation pathway, which involves various factors. This study demonstrated the potential of the bioactive compounds of S. platensis for modulating immune function by reducing inflammation through the inhibition of the NF-κB activation pathway. Phycocyanobilin was predicted to have good potential for molecular docking with multisubunit IκB kinase (IKK)1/IKKA, IKK2/IKKB, NF-κB-inducing kinase, and the IκBα/NF-κB complex. Furthermore, β-carotene exhibited good potential for interactions with NF-κB essential modulator/IKK and the NF-κB complex, …