Medicine and Health Sciences Commons^™

Clinico-Epidemiological Profile Of Iron Deficiency Anemia Among Egyptian Primary School Aged Children: A Hospital Based Study, Rabab Fathy Abdelhamid, Noha Essam, Mona Mohamed Taalab

Mansoura Medical Journal

Background: Iron deficiency anemia (IDA) is the most prevalent cause of anemia among Egyptian children and is associated with a range of hematologic and non-hematologic complications, some of which may be irreversible. This study aims to evaluate the clinical profile and identify factors associated with severe IDA in primary school–aged children.

Methods: This cross-sectional study included 420 primary school–aged children diagnosed with IDA who attended the outpatient clinic of Salamoun El-Qumash Family Medicine Centre. Data were collected through face-to-face interviews using a structured questionnaire. All participants underwent a thorough clinical examination and laboratory evaluation, including a complete blood count and …

The Prognostic Value Of Arterial Spin Labeling Mri In Middle Cerebral Artery Ischemic Stroke Patients Receiving Thrombolytic Therapy, Ahmed Effat Saied, Nihal Mohamed El-Batouty, Mohamed Abdel Salam Ali, Merehan Reda Abo Alnaga

Mansoura Medical Journal

Background: Reestablishing blood circulation to the brain represents the primary proven treatment goal for acute ischaemic stroke (AIS). Recombinant tissue plasminogen activator (r-TPA) is a thrombolytic medication that enhances the rate of arterial blood flow restoration, reestablishes tissue perfusion, and leads to better functional recovery. This research aimed to examine changes in regional brain perfusion identified through arterial spin labeling (ASL) and how these changes correlate with functional recovery following ischemic stroke. Methods: This prospective observational research included 50 subjects with AIS in the middle cerebral artery (MCA) territory who were eligible for r-TPA treatment. Each patient underwent comprehensive neurological …

Outcome Of Conservative Management Of Placenta Accreta Spectrum In Mansoura University Hospital, Nasra Hassan Mohamed, Mohamed Mohamed Eltotongy, Maher Elesewi Kamel Elgaly

Mansoura Medical Journal

Background: Placenta accreta spectrum (PAS) represents a significant global health challenge, with its incidence rising in parallel with the increasing prevalence of cesarean sections (CS). While cesarean hysterectomy is traditionally considered the standard treatment, conservative management offers a fertility-preserving alternative in carefully selected cases. This study aimed to evaluate the safety and effectiveness of conservative treatment for PAS at Mansoura University Hospital over a two-year period.

Methods: This retrospective analytical study included 132 women diagnosed with placenta accreta who underwent conservative management. Patient data, including obstetric history, degree of accreta, bleeding episodes, timing of delivery, and the specific uterine-sparing technique …

The Role Of Vitamin D In Management Of Pediatric Chronic Immune Thrombocytopenia, Eman Magdy Yahia, Suzy Abd El Mabood Abd El Hameed, Dalia Tawfeek Hussein, Amany Mamdouh Shoumah

Mansoura Medical Journal

In children, immune thrombocytopenia (ITP) remains a serious health concern, which is an autoimmune disorder (AID) characterized by an isolated decrease in platelet count, leading to an increased risk of bleeding.

The use of vitamin D supplementation represents a turning point in many autoimmune diseases, with the potential to deliver high cure rates with fewer side effects than previous therapies. In this review, we explore the incidence of ITP , immunopathogenesis, diagnosis and management in pediatric patients. We will discuss the mechanisms of action of vitamin D , focusing on its role in autoimmune diseases especially ITP

Predictive Value Of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio And Ca-125 Dynamics After Neoadjuvant Chemotherapy For Surgical Outcomes And Prognosis In Ovarian Cancer, Asmaa S. Othman, Hend M. Serya, Manar H. Ahmed, Asmaa F. Elfayoumey

Mansoura Medical Journal

Background: The prognosis of patients with advanced-stage epithelial ovarian cancer (EOC) having debulking surgery is greatly influenced by optimal resection. Neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and CA-125 values are examples of inflammatory markers that have been identified as possible predictive markers.

Objective: This study evaluated neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and CA-125 dynamics as predictors of surgical outcomes and survival in advanced ovarian cancer patients receiving neoadjuvant chemotherapy (NACT).

Methods: We conducted a retrospective analysis of 171 patients treated at Mansoura University (2020-2025) with platinum-taxane neoadjuvant chemotherapy followed by interval debulking surgery (IDS). Pre- …

Effect Of Graft Steatosis On The Early Outcome Of Living Donor Liver Transplantation, Kareem Maher Shams Eldeen Hassan, Ahmed Mahmoud Abdelrafee, Ahmed Mohamed Ibrahim Elsabbagh, Mohamed Abd Elwahab Ali

Mansoura Medical Journal

Background

Hepatic steatosis in donor grafts represents a growing challenge in living donor liver transplantation (LDLT) due to the rising prevalence of metabolic syndrome. The impact of varying degrees of graft steatosis on recipient and donor outcomes remains incompletely defined.

Aim

To evaluate the effect of different degrees of graft steatosis on early postoperative outcomes in both recipients and donors following LDLT.

Methods

This retrospective study analyzed 169 LDLT cases performed at Mansoura University between January 2014 and June 2024. Donors aged 18-45 years with BMI≥5% on liver biopsy were included. Grafts were stratified by steatosis degree:20% (n=4). Primary outcome …

Impact Of Covid-19 Infection On Left Ventricular Systolic And Diastolic Functions., Hazem Galal Mohamed, Maged Zaghloul Mohamed Amer, Aml Fathy Moustafa, Shady Hussein Mohamed

Mansoura Medical Journal

Background: SARS-CoV-2, the pathogen behind COVID-19, often involves the cardiovascular system due to high ACE2 receptor density in myocardial tissue. While immediate cardiac complications are recognized, the persistent effects on left ventricular (LV) performance require further investigation through echocardiography.

Aim: This study aimed to comprehensively describe the sequelae of COVID-19 infection on the left ventricle using echocardiography

Methods: The study included 100 participants. Cardiac function was assessed using a standard 12-lead ECG and transthoracic echocardiography. LV systolic function was evaluated using the Biplane Simpson Method, and myocardial contractility was further analyzed using Speckle-Tracking Echocardiography (STE).

Results: The mean age was …

Effect Of Graft Weight On Splenic Volume After Living Donor Liver Transplant, Raghda Adel Mohammed, Amina Ahmed Sultan, Eman Mohammed Helmy, Mohamed Samy Habl

Mansoura Medical Journal

Background: In recipients of liver transplantation (LT), spleen volume reflects the portal hemodynamic status. Optimization of graft weight and studying its effect on the outcomes on the splenic volume after the transplant is one of the techniques for portal inflow modulation.  Aim: The study aims to assess the degree of splenic volume reduction after living donor liver transplantation in correlation to graft weight. Methods: The study analyzed 29 liver transplantation patients, involving comprehensive history taking, clinical examination, and laboratory data assessment. Spleen volume has been measured via a semi‑automatic region‑based technique with subsequent manual refinement when necessary to accurately delineate …

Patterns Of Bilirubin Decline After Biliary Stenting In Malignant Obstructive Jaundice, Omar Abdallah, Shymaa Abdelghany, Mohamad A. Ebrahim, Hassan Atalla

Mansoura Medical Journal

Background: Malignant extrahepatic biliary obstruction (MEBO) is a common cause of obstructive jaundice associated with high morbidity and mortality. ERCP-guided biliary drainage is widely used for palliative management, however, real-world data regarding bilirubin decline and predictors of success remain limited. This study aimed to evaluate bilirubin decline patterns, clinical outcomes, and predictors of clinical success following ERCP-guided biliary drainage in patients with MEBO.

Methods: This prospective observational study included consecutive MEBO patients who underwent ERCP-guided biliary drainage either by plastic or metallic stents at a tertiary-care hospital. Technical success, defined as successful stent placement, and clinical success, defined as symptomatic …

Role Of Positron Emission Tomography-Computed Tomography (Pet-Ct) In Evaluation Of Hepato-Cellular Carcinoma, Mona Baz, Ahmed Youssef Kandeel, Mohamed Ali El-Adalany, Dina El-Metwally

Mansoura Medical Journal

Background: Globally HCC appeared to be the third main reason of mortality associated with cancer.  According to degree of differentiation, HCC can be classified into four grades. PET/CT represents a functional imaging technique that offers metabolic insights into the tumor. It may play a substantial turn in prediction of biological behavior of HCC, predicting tumor grade and presence of microvascular invasion.

Aim of the work:  This work aimed to assess the utility of 18F-FDG PET/CT in identification of primary hepatocellular carcinoma (HCC) and in predicting its histological grade.

Methods: A total of 52 patients with established HCC were included in …

Clinical Outcomes Of Ultrasound-Guided Tmj Arthrocentesis In Post-Traumatic Internal Derangement: A Prospective Single-Arm Clinical Study, Ahmed Emad Mohamed Ghaly, Nabil Mokhtar Mohammed, Mohamed Radwan Elhadidy, Mohammed Hassan El Fahar

Mansoura Medical Journal

Background: The most common condition is temporomandibular joint (TMJ) internal derangement (ID). common TMJ disorder. It is defined as an abnormal displacement of the articular disc from its normal position relative to the condyle during joint function.

Aim: To evaluate the clinical outcomes of ultrasound-guided temporomandibular joint (TMJ) arthrocentesis in patients with post-traumatic internal derangement, the effectiveness of the procedure in reducing pain intensity, improving mandibular range of motion (maximum mouth opening and lateral excursions), decreasing TMJ clicking, and determining the overall clinical success rate over a 6-month follow up period.

Patients and methods: This prospective single-arm non-randomized study was …

Epidemiologic, Clinical And Genetic Characteristics Of Familial Mediterranean Fever In Egyptian Children’S Tertiary Care Center, Ghada Ahmed Elsayed Mgahed, Mayada Sabry Zeid, Ali Sobh, Shaltout A

Mansoura Medical Journal

Background: Familial Mediterranean fever (FMF) is an inherited disorder known by recurrent, brief, and self-limiting episodes of fever and serosal inflammation. It is primarily defined by acute inflammatory involvement of serosal membranes, including the pleura, peritoneum, and/or synovial tissues, typically associated by fever. This inflammatory cascade is inherently self-propagating and, if inadequately controlled, may lead to recurrent episodes or sustained inflammatory activity.

Aim of the work: To examine the clinical and demographic characteristics of individuals with childhood- initiation FMF, to determine the prevalence of the most frequent mutations in the FMF-linked gene within this population, and to assess the …

Impact Of Early Injection Laryngoplasty On Voice Outcomes And Quality Of Life In Acute Unilateral Vocal Fold Paralysis, Abdelrhman Ali Kamal, M El-Kotb, Hemmat Mostafa Baz, Ahmed S. Abdelmeguid

Mansoura Medical Journal

Background

Unilateral vocal fold paralysis (UVFP) leads to glottic insufficiency, resulting in dysphonia, reduced vocal strength, and frequently swallowing difficulties that impair communication and quality of life. Injection laryngoplasty with temporary materials such as hyaluronic acid has been shown to improve voice quality and phonatory function in UVFP patients and may serve as an effective early intervention prior to permanent medialization surgery.

Objective

To assess the impact of early injection laryngoplasty on voice outcomes and voice related quality of life in patients with acute unilateral vocal fold paralysis.

Methods

This prospective study included 24 patients with acute UVFP treated with …

Predictors Of Outcomes Of Adult Mandibular Fractures: A Prospective Study., Norhan Yahia El-Henawy, Mohamed Ali Mahgoub, Mohamed Radwan El-Hadidy, Ahmed Hassan El-Sabbagh

Mansoura Medical Journal

Background: Mandibular fractures not only cause physical disfigurement and functional impairments but also significantly affect the patient’s psychological, emotional, and social well-being. Predictors are variables that may influence or explain variation in the outcome of mandibular fracture. Aim of work: To evaluate demographic, clinical, radiological, and psychosocial factors associated with early postoperative complications and postoperative depressive symptoms following surgical management of adult mandibular fractures. Methods: A prospective study evaluated patients who will undergo treatment for surgical mandibular fracture/s at Mansoura Emergency Hospital, DK, from August 2023 to July 2024. The patients were assessed by history taking, clinical picture, radiological tools, …

Quality-Of-Life Outcomes Of Tympanoplasty/Mastoidectomy Operations, Peter Shokr Meglaa, Ahmed Hemdan Eldeeb, Hisham Atef Abada, Yousef Kamel Shabana

Mansoura Medical Journal

Background: Chronic suppurative otitis media (CSOM) impairs quality of life (QoL) via otorrhea, hearing loss, and psychosocial effects, with surgery (tympanoplasty/mastoidectomy) as mainstay treatment despite limited patient-centered outcome data. This study aimed to evaluate QoL changes post-tympanoplasty/mastoidectomy in CSOM using validated tools.

Methods: This prospective study included 50 adults with CSOM at Mansoura University Hospitals. Pre/postoperative assessments included Chronic Otitis Media Outcome Test-15 (COMOT-15), Short Form-36 Health Survey (SF-36), Hearing Handicap Inventory for the Elderly-Screening (HHIE-S), Tinnitus Evaluation Questionnaire (TEQ), Situational Vertigo Questionnaire (SVQ), pure tone audiometry (PTA), and air-bone gap (ABG).

Results: PTA improved from 48.5±10.2 to 28.3±8.4 dB …

Red Cell Distribution Width As A Prognostic Factor And Its Comparison With Lactate In Patients With Sepsis: An Observational Prospective Cohort Study, Ahmed Taha Gad, Ghada Fathy El-Rahmawy, Naglaa Abd El-Latif El-Negeery, Eiad Ahmed Ramzy

Mansoura Medical Journal

Background: Red blood cell distribution width (RDW) is a straightforward and cost-effective parameter that is utilized in laboratory hematology to differentiate anemias. It is indicative of the grade of heterogeneity in erythrocyte volume. This study purpose examine the correlation among the risk of adverse results in patients with sepsis and RDW, as well as to equivalence the mortality discriminative capacity of RDW and lactate levels.

Methods: This observational prospective cohort study was done on 67 sepstic patients aged ≥ 21 years old, both sexes. Patients were owed into two groups according to RDW levels: Group A (n=35): normal RDW …

Diffusion Weighted Magnetic Resonance Imaging In Rectal Cancer, Ebtehal A. Mohamed, Fatma Mohamed Sherif, Wael Abdulghaffar, Ahmed M Fareed, Gehad A. Saleh

Mansoura Medical Journal

Background: Rectal cancer (RC) is a major cancer burden globally as it is among the tumors that are most frequently diagnosed worldwide and a significant contributor to global cancer mortality yearly. Imaging with diffusion weighting (DWI) and Magnetic resonance imaging (MRI) is the best radiological modality for the local staging and restaging of RC due to its excellent soft-tissue contrast and high spatial resolution.

Aim of the work: This study aims to assess the value of DW-MRI in staging and assessing treatment response in patients with RC who received concurrent chemoradiotherapy.

Methods: Forty-two patients with RC diagnoses …

The Potential Role Of Naftidrofuryl Oxalate In Rat Model Of Ulcerative Colitis, Omar Mohsen Elmazny, Ahmed Abdel-Monem Elmetwally, Vivian Boshra, H.M. El-Beltagi, Basma Hamed Othman, Heba Sheta

Mansoura Medical Journal

Background: Ulcerative colitis (UC) is a chronic, recurrent bowel disease characterized by inflammation that leads to superficial damage to the colon wall. The rate of incidence of UC differs from 0.5 to 31.5 per 100,000 subjects annually. The exact cause is still not well-identified. Studies suggest genetic factors, altered immune response, and environmental factors may play a role in the initiation and progression of the disease. Its pharmacological treatment remains unsatisfactory. Aim: To assess the possible protective effect of Naftidrofuryl oxalate (NFT) (praxilene) on intestinal epithelial cells in acetic acid (AA)-induced UC model in rats.  Materials and Methods: sixty female …

Hypoalbuminemia As A Predictive Factor For Acute Kidney Injury In Pediatric Patients Running Title: Hypoalbuminemia In Aki Pediatrics, Kareem El-Saeed El-Maasrany, Ayman Hammad, Hosam Zaghloul, Ahmed Elhusseiny

Mansoura Medical Journal

Aim: Hypoalbuminemia is a well-known risk factor for illness and death, but its role as a particular predictor of acute kidney injury (AKI) is still not fully understood. This study intended to evaluate the role of hypoalbuminemia as a predictive factor for AKI outcome among pediatric patients, regarding hospital stay, kidney replacement therapy and mortality rate.

Subjects and Methods: This prospective observational cohort was conducted on 70 children with AKI divided into two groups: group I (35 AKI children combined with hypoalbuminemia) and group II (35 AKI children without hypoalbuminemia). All participants were subjected to full history taking, clinical examination …

Added Value Of T2 Space Stir In Magnetic Resonance Imaging Evaluation Of Post-Traumatic Brachial Plexus Injury, Nehal Tharwat, Ahmed Mohamed Abdelkhalek, Mohamed Ashraf Abd El-Moniem, Hesham Abdel Fattah Elsobky, Ahmed Alaa El-Din Elagamy

Mansoura Medical Journal

Background: Traumatic brachial plexus injuries (TBPIs) cause severe upper limb disability. Owing to the complex anatomic architecture of the brachial plexus (BP), TBPIs are difficult to diagnose. Magnetic resonance neurography of the BP using three-dimensional isotropic imaging provides excellent background fat suppression and adequate soft-tissue contrast, thereby allowing better delineation of the BP along its pathway. This study aimed to compare image quality between T2-Short tau inversion recovery (T2-STIR) and 3D-transverse relaxation time-sampling perfection with application of optimized contrasts using different flip-angle evolution short tau inversion recovery (3D-T2 SPACE STIR) sequences in cases of TBPIs.

Methods: This study included 44 …

The Role Of Adult Appendicitis Score In Reducing The Negative Appendectomy Rate, Mohamed Mahmoud Mansour El Ghzzawy, Magdy Basheer, Mohamed Balata, Amir A. Fikry

Mansoura Medical Journal

Aim: Approximately 15 – 30% of all acute appendectomies are performed based only on clinical suspicion. A negative appendectomy has a 10–12% morbidity rate, which could be detrimental to patients. The current study aimed to evaluate the effectiveness of adult appendicitis score (AAS) in accurate identification of cases with acute appendicitis.

Patients and Methods: This prospective observational study was conducted on 150 patients who presented with manifestations of acute appendicitis admitted to Mansoura Emergency Hospital.  The AAS was calculated, the decision on appendectomy was solely based on the surgeon’s clinical judgment after taking into consideration all the findings of clinical, …

Evaluation Of Β2-Microglobulin In Patients With Psoriasis Vulgaris Case Controlled Study, Ishraq Mazhar Shaaban, Fatma Faisal El Dakrory, Alshaimaa Hamdi Abd Elmaksoud, Youssef El-Bayoumi Youssef Soliman

Mansoura Medical Journal

Background: Psoriasis is a persistent, immune-mediated dermatological condition influenced by complex genetic architectures and systemic inflammation. This investigation evaluated the diagnostic utility of serum β2-microglobulin β2 as a quantitative indicator for gauging clinical severity in psoriatic patients.

Aim of the work: The primary objective of this investigation was to evaluate the diagnostic utility of serum β2-microglobulin (β2M) as a quantitative biomarker for assessing disease severity in patients with psoriasis vulgaris. Specifically, the study sought to determine the correlation between circulating β2M levels and established clinical parameters, including the Psoriasis Area and Severity Index (PASI), body mass index (BMI), and …

Assessment Of Health-Related Quality Of Life In Pediatric Patients With End Stage Renal Diseases, Nasteho Adan Awil, Ahmed Mahmoud Elrefaey, Abdel-Hady El-Gilany Abdel-Elfattah, Heba Mohamed El-Taher

Mansoura Medical Journal

Background: End-stage renal disease (ESRD) occurs when the glomerular filtration rate falls below 15 mL/min, requiring renal replacement therapy. Despite improved survival, affected children experience significant physical, emotional, and social challenges. Consequently, health-related quality of life (HRQoL) is markedly reduced compared with healthy peers.

Aim: This study aimed to assess health-related quality of life (HRQOL) in pediatric patients with end-stage renal disease (ESRD) and to identify factors associate with the quality of life in pediatric patients with   end stage renal disease (ESRD).

Methods:  All 60 eligible children who were enrolled in the Nephrology Unit at Mansoura University Children's Hospital …

Evaluation Of Cardiac Troponin T And Ischemia-Modified Albumin Changes With Hemodialysis Session In Pediatric Patients With End-Stage Renal Disease, Zeinab Ezz Elden Abass Abd Eldayem, Ashraf Mohammed Abdel Basset, Gehan Attia Abdehakem, Shiama Abdelmgiad, Nermin Yossef Abo Elkheir

Mansoura Medical Journal

Background : Cardiovascular status in dialysis patients is complicated by a wide range of factors that can affect long-term prognosis. Cardiac biomarkers changes with hemodialysis session could affect the cardiac integrity of those patients. Aim of the work: Assess the changes of cardiac ischemic biomarkers (Troponin T and ischemia modified albumin) before and after hemodialysis session in patients with ESRD in pediatric age group and study of correlations of changes with the hemodialysis parameters. Patients and methods: The study included 40 pediatric ESRD patients who were admitted to Pediatric Cardiology Unit, Pediatric Nephrology and Dialysis Unit of Mansoura University Children’s …

Fascia Transversalis Block With Different Volumes Of Local Anesthetic And Its Impact On Postoperative Pain In Major Abdominal Surgery: Prospective Randomized Study, Eman Eltabey Lotfi Taman, Mostafa Mohamed Ali Saied, Khaled Mohy Eldeen El Bahrawy, Abdelrahman Mamdouh El Naggar

Mansoura Medical Journal

Background Effective postoperative analgesia remains crucial in abdominal surgery to reduce physiological stress, improve respiratory function, and enhance recovery. The transversalis fascia plane block (TFPB) has recently emerged as an advantageous technique targeting the T12–L1 nerves responsible for somatic and visceral abdominal innervation. Objective To investigate the analgesic efficacy of different volumes of local anesthetic administered in TFPB and compare their effect on postoperative pain, visceral discomfort, and opioid requirements. Methods Eighty-one adult patients undergoing major abdominal surgery under general anesthesia were randomized into 3 groups: control (systemic analgesia only), lowvolume TFPB (20 mL total), and high-volume TFPB (25 mL …

Diagnostic Performance Of Digital Breast Tomosynthesis In The Characterisation Of Breast Lesions: Correlation With Sono-Mammography And Histopathology., Amira Hamed Megahed, Mona Mahmoud Zaky, Maha Mohamed Bilal

Mansoura Medical Journal

Background: Breast lesions range from benign to malignant, with early detection critical for management. Digital mammography is the standard screening tool but may be limited in dense breasts. Ultrasound (US) aids lesion characterisation, while digital breast tomosynthesis (DBT) reduces tissue overlap, enhancing lesion detection.

Objective: To evaluate the diagnostic performance of digital breast tomosynthesis in the characterisation of breast lesions compared with sono-mammography, using histopathology as the reference standard.

Methods: This prospective study included 33 symptomatic female patients with a mean age (45.4 ± 8.2 years) who presented with symptoms such as palpable breast lumps, Mastalgia and nipple discharge between …

Assessment Of Serum Level Of Lipocalin-2 In Patients With Alopecia Areata, Mohammed S. Sultan, N. M. Darwish, Hosam Abdel Tawab, Asmaa M. Shalaby

Mansoura Medical Journal

Background: Alopecia areata (AA) is a chronic autoimmune disease (AID)-causing non-scarring hair loss (NSHL), mainly on the scalp. It affects about 2% of people worldwide, usually starting in the third or fourth decade. This study aimed to evaluate serum lipocalin-2 levels in AA patients compared to healthy controls (HC), and to examine their correlation with disease severity Methods: This one-year prospective case-control study included 40 AA patients from Mansoura University Hospitals and 40 age- and sex-matched healthy control. Diagnosis was based on typical, well-defined non-inflammatory scalp hair loss (HL) confirmed by dermoscopy. Controls were healthy, with no autoimmune history or …

Comparative Study Between Serum Levels Of Interleukin-19 And Interleukin-38 In The Egyptian Patients With Non-Segmental Vitiligo, Reem Ahmed Al Maaddawy, Mohamed Kh. Selim, Ahmed Fawzi Ismail, Ahmad S. Hasan, Manar Ali Hassan

Mansoura Medical Journal

Background: The precise etiology of vitiligo remains unclear; nonetheless, it is predominantly regarded as an autoimmune disorder. This work aimed to compare serum levels of IL-19 and IL-38 between patients with non-segmental vitiligo (NSV) and healthy controls (HC). Patients and Methods: This study included 88 participants, evenly split into two groups: 44 individuals with non-segmental vitiligo and 44 healthy controls. Both groups underwent full history taking. The Vitiligo Area Severity Index (VASI) score and Vitiligo Disease Activity (VIDA) score were used to assess disease severity and activity. The levels of human IL-19 and IL-38 were also measured.

Results:Serum IL-38 …

A Comparative Study Of Topical 5% 5-Fluorouracil With Needling Versus 100% Trichloroacetic Acid With Needling Versus Needling Alone In Treatment Of Multiple Warts, Nesma Abd-Elmonem Saad, Hassan A. Fayed, Manar Ali

Mansoura Medical Journal

Aim: This study aimed to compare the efficacy and safety of topical 5% 5-Fluorouracil (5-FU) with Needling versus 100% Trichloroacetic acid (TCA) with Needling versus Needling Alone in treatment of multiple warts.

Methods: This study included a total of 60 patients clinically diagnosed with multiple warts, who were randomly allocated (computer-generated simple randomisation, 1:1:1, concealed in sequentially numbered opaque sealed envelopes) into three equal groups (n=20 per group). The first group received 100% TCA with Needling; the second group received topical 5% 5-FU combined with Needling; the third group underwent Needling alone. The study was single-blinded at the level …

Active Deresuscitation Strategies After Septic Shock: A Scoping Review, Alrefaey K. Alrefaey, Rania E Elbadrawy, Mohamed Aboelela, Mohammed Mamoun

Mansoura Medical Journal

Background: Fluid overload in septic shock patients is linked to higher morbidity and mortality. After the stabilization phase, fluid restriction may not result in the resolution of tissue edema. Active deresuscitation refers to the use of diuretics or ultrafiltration for the removal of excess fluids. Objectives: This review explores the current practices applied for the active deresuscitation strategies after stabilization of septic shock patients.  Search strategy: A literature search was performed through the following databases: Medline, PubMed, Google Scholar, Web of Science, and Scopus for relevant studies from 2015 to January 2026. Selection criteria:  The selected articles included …