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Articles 61 - 77 of 77
Full-Text Articles in Medicine and Health Sciences
Pathological Alterations In Gabaergic Interneurons And Reduced Tonic Inhibition In The Basolateral Amygdala During Epileptogenesis, Michael A. Rogawski, Brita Fritsch, Felicia Qashu, T. H. Figueiredo, Vicki Aroniadou-Anderjaska, Maria F.M. Braga
Pathological Alterations In Gabaergic Interneurons And Reduced Tonic Inhibition In The Basolateral Amygdala During Epileptogenesis, Michael A. Rogawski, Brita Fritsch, Felicia Qashu, T. H. Figueiredo, Vicki Aroniadou-Anderjaska, Maria F.M. Braga
Michael A. Rogawski
An acute brain insult such as traumatic head/brain injury, stroke, or an episode of status epilepticus can trigger epileptogenesis, which, after a latent, seizure-free period, leads to epilepsy. The discovery of effective pharmacological interventions that can prevent the development of epilepsy requires knowledge of the alterations that occur during epileptogenesis in brain regions that play a central role in the induction and expression of epilepsy. In the present study, we investigated pathological alterations in GABAergic interneurons in the rat basolateral amygdala (BLA), and the functional impact of these alterations on inhibitory synaptic transmission, on days 7 to 10 after status …
The Effects Of Qualitative And Quantitative Protein Malnutrition On Cecal Microbiota In Wistar Rats With Or Without Neutrophil Suppression, Hali̇l Biyik, Muharrem Balkaya, Hümeyra Ünsal, Cengi̇z Ünsal
The Effects Of Qualitative And Quantitative Protein Malnutrition On Cecal Microbiota In Wistar Rats With Or Without Neutrophil Suppression, Hali̇l Biyik, Muharrem Balkaya, Hümeyra Ünsal, Cengi̇z Ünsal
Turkish Journal of Veterinary & Animal Sciences
Gastrointestinal microbiota has been claimed to be affected by the diet consumed. In this study the effects of severe qualitative and quantitative protein malnutrition on cecal microbiota of male Wistar rats with or without neutrophil depletion were investigated. A total of 43 animals were divided randomly into 7 groups. Group I (control) was given a complete chow diet, groups II, III and IV received almost protein free (N-free) diet and groups V, VI and VII received a 20% gelatin containing diet for 35 days ad libitum. In addition, groups I, II and V were given physiologic saline, groups III and …
The Effects Of Fenfluramine On Blood And Tissue Serotonin (5-Hydroxytryptamine) Levels In Rats, İbrahi̇m Pi̇ri̇nçci̇, Ahmet Ateşşahi̇n, İzzet Karahan
The Effects Of Fenfluramine On Blood And Tissue Serotonin (5-Hydroxytryptamine) Levels In Rats, İbrahi̇m Pi̇ri̇nçci̇, Ahmet Ateşşahi̇n, İzzet Karahan
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to investigate the effect of fenfluramine (FEN) administered at single and repeated doses on brain, stomach and plasma serotonin (5-Hydroxytryptamine, 5-HT) levels in rats. FEN was injected intraperitoneally at single doses (1, 3 and 10 µmol kg^{-1}) and given orally at repeated doses (1.25, 5 and 10 mg kg^{-1}) for 21 days. The tissues and plasma samples were collected 20, 40, 80 and 160 minutes after the single dose administrations and 4 h after the last dose administration in repeated experiments. In addition, the rats treated with the dose of 1.25 mg kg^-1 were …
6-Phosphogluconate Dehydrogenase: Purification, Characterization And Kinetic Properties From Rat Erythrocytes, Şükrü Beydemi̇r, Mehmet Çi̇ftçi̇, Hayrullah Yilmaz, Ömer İrfan Küfrevi̇oğlu
6-Phosphogluconate Dehydrogenase: Purification, Characterization And Kinetic Properties From Rat Erythrocytes, Şükrü Beydemi̇r, Mehmet Çi̇ftçi̇, Hayrullah Yilmaz, Ömer İrfan Küfrevi̇oğlu
Turkish Journal of Veterinary & Animal Sciences
In this paper, a simple and rapid method for the purification of 6-phosphogluconate dehydrogenase from rat erythrocytes together with an analysis of the kinetic behavior and some properties of the enzyme are considered. The purification steps comprised high-speed centrifugation, 20-50% ammonium sulfate precipitation and 2', 5'-ADP Sepharose 4B affinity gel chromatography. The yield was 78.4% and the specific enzyme activity was 5.15 EU/mg proteins. The molecular mass of the subunit was estimated to be 59,566 Da by SDS polyacrylamide gel electrophoresis (SDS-PAGE) and native enzyme was found to be 111,000 Da by gel filtration column chromatography. The enzyme had an …
Effects Of Phenobarbital On Serum And Liver Paraoxonase And Arylesterase Activities In Rats, Ahmet Ateşşahi̇n, İzzet Karahan, İbrahi̇m Pi̇ri̇nçci̇, M. Feri̇t Gürsu, Funda Gülcü
Effects Of Phenobarbital On Serum And Liver Paraoxonase And Arylesterase Activities In Rats, Ahmet Ateşşahi̇n, İzzet Karahan, İbrahi̇m Pi̇ri̇nçci̇, M. Feri̇t Gürsu, Funda Gülcü
Turkish Journal of Veterinary & Animal Sciences
This study was carried out to determine the effects of phenobarbital, administered orally and intraperitoneally over different periods, on paraoxonase, arylesterase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and total protein levels in the serum and liver. Thirty-six rats, 16-18 weeks old and weighing 240-260 g, were used. Phenobarbital was applied both orally and intraperitoneally at a dose of 100 mg/kg. Paraoxonase and arylesterase activities in serum and liver samples were measured spectrophotometrically using paraoxon and phenylasetate substrates, respectively. Although no significant changes were determined in serum paraoxonase and arylesterase activities, liver paraoxonase and arylesterase activities and total protein …
Morphometry Of The Lymph Nodes Excluding The Thoracic And Abdominal Cavity In Wistar Rats, İlknur Dabanoğlu, Hüsnü Erbay Bardakçioğlu, Fi̇gen Sevi̇l, Di̇dem Alp
Morphometry Of The Lymph Nodes Excluding The Thoracic And Abdominal Cavity In Wistar Rats, İlknur Dabanoğlu, Hüsnü Erbay Bardakçioğlu, Fi̇gen Sevi̇l, Di̇dem Alp
Turkish Journal of Veterinary & Animal Sciences
Ten male adult Wistar rats were used to obtain some measurements of the lymph nodes located in the head, neck, forelimb and hindlimb. The lymph nodes were marked by the injection of Evans Blue and were then dissected. In order to provide sufficient data for the morphometric properties of lymph nodes, the lymph nodes on each side were counted, and the longest and widest diameters of the lymph nodes were also measured. The mandibular lymph nodes were found to be higher in number in comparison with the other lymph nodes investigated. The largest was found in the axillary accessory lymph …
The Effects Of High Copper And Zinc On Some Hematological Parameters In Rats, Sebahat Aydemi̇r, Mukaddes Özcan
The Effects Of High Copper And Zinc On Some Hematological Parameters In Rats, Sebahat Aydemi̇r, Mukaddes Özcan
Turkish Journal of Veterinary & Animal Sciences
The effect of high levels of Zn and Cu supplemented into the diet on Zn and Cu levels in the liver, pancreas and serum, the number of red and white blood cells, hematocrit value, hemoglobin levels, superoxide dismutase (SOD) activity in red blood cells, live weight, and liver and pancreas weights were investigated. A total of 77 Wistar albino rats were used as the research material. Twelve of the rats were separated as the control group and the remaining 65 were divided into five experimental groups (D1, D2, D3, D4 and D5) with 13 rats in each. Then, 70 mg/kg/day …
The Effect Of Zinc On Body Weight And Some Serum Enzymes In Rats, Süleyman Korkut Tekeli̇, Nezi̇r Yaşar Toker, Fatma Tekeli̇
The Effect Of Zinc On Body Weight And Some Serum Enzymes In Rats, Süleyman Korkut Tekeli̇, Nezi̇r Yaşar Toker, Fatma Tekeli̇
Turkish Journal of Veterinary & Animal Sciences
100 male Wistar albino rats were used in this study. After the adaptation period, the rats were divided into 5 equal groups. The experimental period lasted 22 days. Food and water were given ad libitum. 0 ppm, 100 ppm, 500 ppm, 1,000 ppm and 2,000 ppm zinc were given by nasogastric probe to the control, experiment-1, experiment-2, experiment-3 and experiment-4 groups respectively, on days 1, 6, 11, 16, and 21 of the experimental period. The animals were weighed and blood samples were taken on days 2, 7, 12, 17, 22 of the experimental period. AST, ALT and ALP levels in …
Morphological Adaptation Of Rat Skeletal Muscle To A Cold Environment, Fati̇me Geyi̇koğlu, Aysel Temelli̇, Abdullah Özkaral
Morphological Adaptation Of Rat Skeletal Muscle To A Cold Environment, Fati̇me Geyi̇koğlu, Aysel Temelli̇, Abdullah Özkaral
Turkish Journal of Veterinary & Animal Sciences
Male Sprague-Dawley rats (SD) were kept in medium between the postnatal 80^{th} and 130^{th} day while environmental temperature (from 20 to 5 ºC) and photoperiod were decreased gradually. The weight of the animals adapted to the cold and the weight and length of the external digitorum longus (EDL) muscle were measured. When compared with controls, in a cold environment the weight and fiber length of the muscle was reduced significantly. In addition, EDL muscle was separated into two (red and white) by using the succinic dehydrogenase (SDH) method and the percentage of fiber types and fiber diameters according to mitochondria …
Investigation On The Situation Of Free And Bound Residues On Rats Fed Chicken Liver Containing Free And Bound Aflatoxin B_1 Residues, Mehmet Özdemi̇r
Investigation On The Situation Of Free And Bound Residues On Rats Fed Chicken Liver Containing Free And Bound Aflatoxin B_1 Residues, Mehmet Özdemi̇r
Turkish Journal of Veterinary & Animal Sciences
The aim of the present study is to determine free and bound residues of 3H-aflatoxin B_1 given orally by a gavage at a single dose (1 mg/kg body weight) in the liver tissues of broilers, and to show whether they accumulate as free and bound aflatoxin B_1 residues in the tissues of liver and muscle of the rats that consumed the liver of those broilers. A total of 30 Ross PM-3 broilers and 49 male Sprague-Dawley rats were used in the study. Free aflatoxin B_1 residue in the liver tissues of the chicken treatment group after 12h was found to …
Morphological And Microscopical Examination Of The Rat Brachial Plexus, Ahmet Uzun, Nureddi̇n Cengi̇z, Ahmet Kavakli, Saci̇de Karakaş
Morphological And Microscopical Examination Of The Rat Brachial Plexus, Ahmet Uzun, Nureddi̇n Cengi̇z, Ahmet Kavakli, Saci̇de Karakaş
Turkish Journal of Veterinary & Animal Sciences
The rat brachial plexus was studied morphologically and the average numbers of the fascicles were studied by light microscope. For this purpose, we used 30 Wistar albino adult rats (16 males, 14 females; 180-250 g). The rats were anaesthetized by urethane (0.6 ml/100 g body weight injected i.p.). The brachial plexus was prepared for the microdissection technique and was evaluated in terms of its formation. Sections of the origin level of roots (C_5, C_6, C_7, C_8 and Th_1) and the terminal branches (ulnar, median, radial (musculospiral), axillary (circumflex), and musculocutaneous nerves) were taken and the average numbers of fascicles were …
Antiinflammatory And Antipyretic Activity Of Polygonum Lapathifolium In Rats, Oya Keleş, Tülay Bakirel, Süleyman Şener, Handan Aydin, Keri̇m Alpinar
Antiinflammatory And Antipyretic Activity Of Polygonum Lapathifolium In Rats, Oya Keleş, Tülay Bakirel, Süleyman Şener, Handan Aydin, Keri̇m Alpinar
Turkish Journal of Veterinary & Animal Sciences
This study was conducted to evaluate the pharmacologic effects of Polygonum lapathifolium L. (Polygonaceae), growing naturally in Turkey. The antiinflammatory activity of the ethanol extract of the root and rhizome of P. lapathifolium was evaluated using carrageenan-induced paw edema in rats. Intraperitoneal pretreatment with extract at doses ranging from 100 to 500 mg/kg significantly inhibited the acute phase of this experimental model of the inflammatory process in a dose-dependent manner. At maximal dose (500 mg/kg), it exhibited a significantly higher action when compared with those of other doses and was found to be 1.08 times as active as indomethacin. The …
Epidermal Growth Factor Receptor (Egfr) Immunolocalization In The Male Rat Reproductive Tract During Pre-And Postnatal Periods, Celal Kaloğlu, Hüseyi̇n Eray Bulut, Bi̇lge Onarlioğlu
Epidermal Growth Factor Receptor (Egfr) Immunolocalization In The Male Rat Reproductive Tract During Pre-And Postnatal Periods, Celal Kaloğlu, Hüseyi̇n Eray Bulut, Bi̇lge Onarlioğlu
Turkish Journal of Veterinary & Animal Sciences
A number of recent studies suggest the effects of several growth factors as well as genetic factors on the development and differentiation of the testes and excretory ducts. One of the most important growth factors affecting the development and differentiation of the above-mentioned organs may be epidermal growth factor (EGF). Therefore, the aim of the present study was to investigate the effects of EGF on the development of the testes and excretory ducts of male rats by determining the immunolocalization of EGF receptors in these organs during foetal and postnatal periods. To do this, testicular and excretory duct tissue samples …
Lectin And Peptide Expression In Nodose, Sphenopalatine And Superiorcervical Ganglia Of The Rat, Zafer Soygüder
Lectin And Peptide Expression In Nodose, Sphenopalatine And Superiorcervical Ganglia Of The Rat, Zafer Soygüder
Turkish Journal of Veterinary & Animal Sciences
The presence and distribution of Griffonia SimplicifoliaI-B4 (GSA I-B4) and Calcitonin Gene Related Peptide (CGRP) were studied in the nodose ganglion (NG) (inferior ganglion of the vagus nerve), sphenopalatine ganglion (SPG) and superior cervical ganglion (SCG) of the rat. GSA I-B4 labeling was found in all ganglia tested. Neither SPG nor SCG cell bodies stained with CGRP were undetectable. The pattern of the distribution of GSA I-B4 and CGRP labeled cells were quite similar in the nodose ganglion. They were found in the poles of the ganglion with some marginal labeling. Large numbers of GSA I-B4 and CGRP labeled cells …
The Effect Of Ultraviolet B (Uvb) Radiation On Some Electrolytes In Rats, Mukaddes Özcan, Göknur Akin, Ülker Çöteli̇oğlu, Murat Arslan
The Effect Of Ultraviolet B (Uvb) Radiation On Some Electrolytes In Rats, Mukaddes Özcan, Göknur Akin, Ülker Çöteli̇oğlu, Murat Arslan
Turkish Journal of Veterinary & Animal Sciences
In our research, the effect of UVB radiation on the amounts of Ca^{++}, inorganic P(Pi), K^+, Na^+, Mg^{++} , Cl^- in serums of 22 week- old Wistar-Albino rats was investigated. UVB radiation was applied to trial group animals at dosages used for treatment (4 J/ cm^2) for a period of 4 weeks.The blood samples were taken before the ray application as the control group. At the end of one month there was no change in the amounts of Pi, K^+, Mg^{++} but the level of serum -Ca^{++} increased significantly (P
Efficacy Of Moxidectin Against Aspiculuris Tetrapteraand Syphacia Murisinnaturally Infected Rats, Ayşen Gargili, Erkut Tüzer, Aynur Gülanber, İlker Efil, Vedat Keleş, Meltem Ulutaş, Müfit Toparlak
Efficacy Of Moxidectin Against Aspiculuris Tetrapteraand Syphacia Murisinnaturally Infected Rats, Ayşen Gargili, Erkut Tüzer, Aynur Gülanber, İlker Efil, Vedat Keleş, Meltem Ulutaş, Müfit Toparlak
Turkish Journal of Veterinary & Animal Sciences
In this study, 56 rats (Rattus norvegicus) naturally infected with both Aspiculuris tetraptera and Syphacia muris were used. The animals were randomly divided into the treatment (37 animals) and control (19 animals) groups. Moxidectin (Cydectin enj., %1 Moxidectin) at 0.2 mg/kgbw was given subcutaneously to the treatment group. The faeces of both groups were examined on days 0, 7, 14, 21, 28. The post-mortem examination of one animal from each group was performed to confirm the EPG results on days mentioned above. The percentage efficacy was measured on the basis of the reduction of the eggs. The eggs and adults …
The Effects Of Orally Ethanol Treatment On Serum, Liver And Kidney\Gamma-Gt, Alt And Ast Enzymes Activity And Serum Total Cholesterol And Lipid Levels In Rats, Ayla Özcan, Ahmet Mengi̇
The Effects Of Orally Ethanol Treatment On Serum, Liver And Kidney\Gamma-Gt, Alt And Ast Enzymes Activity And Serum Total Cholesterol And Lipid Levels In Rats, Ayla Özcan, Ahmet Mengi̇
Turkish Journal of Veterinary & Animal Sciences
In this study, some blood, liver and kidney parameters of rats which were given alcohol orally were investigated at the end of 1st, 7th, 14th and 21st days. Forty male Wistar Albino rats (mean 196 g), 20 wk of age, were used as materials. Serum AST and \gamma-GT activities at the end of 1st day were significantly different between control and experimental groups from 40 rats studied. At the end of 7th, 14th and 21st days, the difference between two groups for AST and \gamma-GT activities in serum and liver were significant (p