Medicine and Health Sciences Commons^™

Thriving Transitions: Supporting Children With Autism Through Their Transition To School, Jennica Cano, Angela Blackwell

Summer 2024 OTD Capstone Symposium

Thriving Transitions is an educational guidebook created for parents of children with autism who are transitioning to school. Thriving transitions contains evidence and sensory based strategies for children with autism who are transitioning to school.

Developmental Changes In Electrophysiological Properties Of Auditory Cortical Neurons In The Cntnap2 Knockout Rat, Rajkamalpreet S Mann, Brian L Allman, Susanne Schmid

Anatomy and Cell Biology Publications

Disruptions in the CNTNAP2 gene are known to cause language impairments and symptoms associated with autism spectrum disorder (ASD). Importantly, knocking out this gene in rodents results in ASD-like symptoms that include auditory processing deficits. This study used in vitro patch-clamp electrophysiology to examine developmental alterations in auditory cortex pyramidal neurons of Cntnap2^-/- rats, hypothesizing that CNTNAP2 is essential for maintaining intrinsic neuronal properties and synaptic wiring in the developing auditory cortex. Whole cell patch-clamp recordings were conducted in wildtype and Cntnap2^-/- littermates at three postnatal age ranges (P8-12, P18-21, and …

Neural Mechanisms Of Language Development In Infancy, Scott Huberty, Christian O'Reilly, Virginia Carter Leno, Mandy Steiman, Sara J. Webb, Mayada Elsabbagh, The Basis Team

Publications

Understanding the neural processes underpinning individual differences in early language development is of increasing interest, as it is known to vary in typical development and to be quite heterogeneous in neurodevelopmental conditions. However, few studies to date have tested whether early brain measures are indicative of the developmental trajectory of language, as opposed to language outcomes at specific ages. We combined recordings from two longitudinal studies, including typically developing infants without a family history of autism, and infants with increased likelihood of developing autism (infant-siblings) (N = 191). Electroencephalograms (EEG) were recorded at 6 months, and behavioral assessments at …

Differences In Startle And Prepulse Inhibition In Contactin-Associated Protein-Like 2 Knock-Out Rats Are Associated With Sex-Specific Alterations In Brainstem Neural Activity, Alice Zheng, Kaela E Scott, Ashley L Schormans, Rajkamalpreet Mann, Brian L Allman, Susanne Schmid

Anatomy and Cell Biology Publications

The contactin-associated protein-like 2 (CNTNAP2) gene encodes for the CASPR2 protein, which plays an essential role in neurodevelopment. Mutations in CNTNAP2 are associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. Rats with a loss of function mutation in the Cntnap2 gene show increased acoustic startle response (ASR) and decreased prepulse inhibition (PPI). The neural basis of this altered auditory processing in Cntnap2 knock-out rats is currently unknown. Auditory brainstem recordings previously revealed no differences between the genotypes. The next step is to investigate brainstem structures outside of the primary auditory pathway that mediate ASR and PPI, which are …

The Effect Of Training Program On Autism Spectrum Quotient Scores, Hossein Nazary Sharif, Sarvin Salar, Justin Anthony Haegele

Human Movement Studies & Special Education Faculty Publications

Background: Autism Spectrum Quotient (AQ) functions as an evaluative instrument designed to assess traits associated with autism. Variances exist within the brain of individuals on the autism spectrum. Moreover, certain exercises have the potential to impact specific regions of the brain.

Aim: This study aims to investigate how the program training of this study impact Autism—Spectrum Quotient.

Materials and Methods: Forty-two children aged 7-10 years with ASD were recruited to participate in this study. These children were randomly divided into two groups: the control group (N=10, 7.80±1.35 years) and the experimental group (N=32, age: 8.16±1.16 years). The experimental group underwent …

Movement As Medicine: Dance/Movement Therapy For Individuals With Autism, Parkinson’S Disease, And Cancer, Alessia Zanobini

CMC Senior Theses

Dance/movement therapy (D/MT) is the psychotherapeutic use of expressive, creative movement to support holistic well-being. D/MT views the human being as a single body-mind unit and movement as a manifestation of life experiences. While typically practiced as a mental health intervention, D/MT can be adapted for a variety of populations. This thesis evaluates scientific data for the non-traditional use of D/MT for three conditions: autism, Parkinson’s disease, and cancer. For individuals on the autism spectrum, D/MT can strengthen attunement skills, provide creative communication outlets, and relieve harmful physical manifestations of autism. For individuals with Parkinson’s disease, D/MT can simultaneously ease …

Pre-Pulse Inhibition In Mutated Mice: Studying Compromised Microglial Cells To Discover New Genetic Connections To Autism, Bailey R. Kramarik

Senior Honors Projects, 2020-current

Microglial cells “play a pivotal role in refining neural networks during early critical periods” (Gabriele & Gray, 2020, p. 1). A disturbance in the functioning of these microglial cells contribute to specific characteristics of some neurodevelopmental disorders- including autism spectrum disorder. In this study, we used a mouse model to study disruptions in cell activity, as understanding the biological and genetic background of autism spectrum disorder could help us provide better treatment and therapy options to those diagnosed.

The mutated mice in this experiment have microglial cells with “compromised fractalkine signaling” (Gabriele & Gray, 2020, p. 4-5). We studied multimodal …

Exercise Interventions For Relieving Anxiety Symptoms For People With Autism Spectrum Disorder: A Systematic Review, Kathryn Riis

College of Health Sciences Posters

Background: Clinical anxiety is a common comorbidity in people with autism spectrum disorder (ASD). The focus of interventional therapies tends to be activities which improve gross motor function, communication, social interactions, and other behavioral skills. Certain forms of exercise have been successful in lowering anxiety levels while improving physical function.

Objective: The purpose of this systematic review was to examine the effectiveness of the use of exercise as an intervention to reduce anxiety in people with ASD.

Methods: Two databases, PubMed and Medline, were searched utilizing key terms. This yielded 35 articles for review. PRISMA systematic search procedures identified 9 …

Neuroinflammation, Peripheral Inflammation And Gut Microbiome Profiles In Male Mice From Two Proposed Mouse Models Of Social Behavior Deficits, Sarah Parkinson

Electronic Theses and Dissertations

Autism spectrum disorder (ASD) is a neurodevelopmental disorder marked by social deficits and repetitive actions. A communication pathway exists between the brain and gut called the gut-brain axis. It is thought that gut bacteria can secrete signaling molecules, triggering inflammation across the body. These studies attempt to determine if markers are expressed in two mouse models of ASD behaviors, BTBR and a valproic acid model. Immunohistochemistry of ionized calcium binding adaptor molecule 1 from male mouse brain tissue showed no microglial activation in any group. Cytokine analysis did exhibit an increase in interleukin 1 (IL-1) in male adult mice only. …

Patterns Of Cilia Gene Dysregulations In Major Psychiatric Disorders, Wedad Alhassen, Siwei Chen, Marquis Vawter, Brianna Kay Robbins, Henry Nguyen, Thant Nyi Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli, Pierre Baldi, Amal Alachkar

Pharmacy Faculty Articles and Research

Primary cilia function as cells' antennas to detect and transduce external stimuli and play crucial roles in cell signaling and communication. The vast majority of cilia genes that are causally linked with ciliopathies are also associated with neurological deficits, such as cognitive impairments. Yet, the roles of cilia dysfunctions in the pathogenesis of psychiatric disorders have not been studied. Our aim is to identify patterns of cilia gene dysregulation in the four major psychiatric disorders: schizophrenia (SCZ), autism spectrum disorder (ASD), bipolar disorder (BP), and major depressive disorder (MDD). For this purpose, we acquired differentially expressed genes (DEGs) from the …

An Evaluation Of Wayfinding Abilities In Adolescent And Young Adult Males With Autism Spectrum Disorder, Yingying Yang, Weijia Li, Dan Huang, Wei He, Yanxi Zhang, Edward Merrill

Department of Psychology Faculty Scholarship and Creative Works

Background

Wayfinding refers to traveling from place to place in the environment. Despite some research headway, it remains unclear whether individuals with Autism Spectrum Disorder (ASD) show strengths, weaknesses, or similarities in wayfinding compared with ability-matched typically developing (TD) controls.

Method

The current study tested 24 individuals with ASD, 24 mental-ability (MA) matched TD (MA-TD) controls, and 24 chronological-age (CA) matched TD (CA-TD) controls. Participants completed a route learning task and a survey learning task, both programmed in virtual environments, and a perspective taking task. Their parents completed questionnaires assessing their children’s everyday wayfinding activities and competence.

Results

Overall, CA-TD …

Autism Awareness Among The Lebanese Population, Nourhan El Zein Beirut Arab University, Faculty Of Medicine, Alaa Hajjar, Nadia Jradi Senior Lecturer Of Pediatrics, Department Of Clinical Sciences, Faculty Of Medicine

BAU Journal - Health and Wellbeing

Autism spectrum disorder (ASD) is a developmental disorder characterized by persistent problems in social communication and interaction; it is currently diagnosed in 1 out of every 67 children. Symptoms of ASD are most commonly recognized in the second year of life, but may be present earlier. Although there is no medical cure for autism, some intervention plans can improve attention, learning and related behaviors; outcome is significantly improved if early intervention is provided. Therefore, promoting autism awareness can assure an early diagnosis and subsequently an early intervention to provide each person with ASD the opportunity to achieve the highest possible …

Gut Pathophysiology In Mouse Models Of Social Behavior Deficits, Kyla Scott

Undergraduate Honors Theses

Autism spectrum disorders (ASD) encompass neurodevelopment disorders characterized by atypical patterns of development that impact multiple areas of functioning beginning in early childhood. The etiology of ASD is unknown and there are currently no preventative treatment options. Gastrointestinal symptoms are commonly associated comorbidities. The microbiota-gut-brain axis is a multidirectional communication chain that connects the central and enteric nervous system that relates brain function to peripheral intestinal functions. Changes within this axis have been postulated in ASD. For example, the “leaky gut theory” proposes that chronic inflammation is linked to alterations in the bacterial profiles of the gut microbiome and subsequent …

Caregiver Burden, Coping Mechanisms And Catharsis: An Exploratory Study, Triveni Goswami Vernal

BAU Journal - Health and Wellbeing

Adopting a qualitative approach, with narrative analysis, an attempt will be made to understand the experience of ‘Caregiver Burden’ amongst 5-7 primary caregivers of children with Autism, in India. An attempt will also be made to capture their coping mechanisms and cathartic behaviours, to reduce stress. To this end, a Caregiver Burden Inventory and an Open Ended questionnaire, touching upon the main issues, will be used. The study also aims to perceive how autonomy as a personality trait can play a significant role in empowering oneself as a caregiver and subsequently have noteworthy consequences on the coping mechanisms and cathartic …

Efficacy Of The Feline Temperament Profile In Evaluating Sheltered Cats For Adoption Into Families Of A Child With Autism Spectrum Disorder, Angélique Lamontagne, Rebecca A. Johnson, Gretchen K. Carlisle, Leslie A. Lyons, Jessica L. Bibbo, Colleen Koch, Steven J. Osterlind

Animal Studies Journal

This project was part of the Feline Friends Study, which matches shelter cats with families of children with Autism Spectrum Disorder (ASD) to study children’s social behaviour and cats’ stress. Cats were screened for calm temperament using the Feline Temperament Profile (FTP). The FTP consists of ten phases, with a list of ‘acceptable’ and ‘questionable’ behaviours under each phase. Our aim was to answer the following research questions: What items of the FTP best predict temperament in shelter cats? What are similarities and differences in temperament between cats who qualified or did not qualify for placement? Forty-four shelter cats were …

The Effects Of Therapeutic Riding On Social Skills And Sensory Functioning In Children With Autism, Betsy Donahoe-Fillmore, Mary Insana Fisher, Christy Lee, Jordan Bevins, Cristin Carter, Stephanie Dailey, Kelsey Haynes, Allison Richard, Sarah Soboslay

Physical Therapy Faculty Publications

Purpose and Significance: Therapeutic riding (TR) is equine-assisted riding lessons that are adapted for people with a wide variety of impairments and is often used as an adjunct to traditional therapies. Previous research has shown that TR helped to improve sensory functioning, cognition and social skills in children with Autism Spectrum Disorder (ASD) but sessions have typically been for 10-12 weeks. The purpose of this study was to investigate if social skills and sensory functioning improved after only 8 weeks of TR.

Subjects: Children were recruited from a local TR center. Participants included seven children (5M, 2F) with a diagnosis …

Sleep, Communicative Ability, And Dietary Intervention As Predictors Of Aggression In Children With Autism Spectrum Disorder, Rafat Omar, Elizabeth Gosch, Susan Panichelli Mindel, Johnathan Roberds

Research Day

Aggression is a common behavioral issue in children with Autism Spectrum Disorder (ASD). Aggression is often treated with evidence-based behavioral treatments such as applied behavioral analysis and functional communication training. One form of intervention that has grown in popularity is to alter the child’s diet. The most popular dietary intervention, the Autism Diet, has been utilized as a form of behavior management by parents and guardians for children diagnosed with ASD to address aggressive behavior, however its use has not been strongly supported by research. We propose that a more beneficial way of understanding aggression in ASD is to understand …

Investigating The Role Of Integrin Beta 3 In Dendritic Arborization In The Supragranular Developing Cerebral Cortex, Zachary Logan Holley

Senior Honors Projects, 2010-2019

Integrin subunits have been implicated in axonal and dendritic outgrowth. In particular, a strong positive association has been found between mutations in integrin beta 3 (Itgb3) and autism spectrum disorder, but little is known about neuronal Itgb3 function in vivo. Many forms of autism spectrum disorder are thought to arise from dysfunctional dendritic arborization and synaptic pruning. Global knockout of Itgb3 in mice leads to autistic-like behaviors. Itgb3^-/- mice also have reduced callosal volume, a key neuroanatomical correlate of autism. Here, we test the hypothesis that Itgb3 is required for normal dendritic arborization in layer II/III pyramidal …

Gut Feeling: Good Food, Good Mood, Asia Battle

The Diana McDonald Writer's Challenge

In “Gut Feeling: Good Food, Good Mood,” Asia Battle describes the emerging field of nutritional psychiatry. Her essay explains why psychotropic medications can be unreliable and, over time, even counter-productive for treating ADHD, autism, bipolar disorder, and other disorders with which children are being increasingly diagnosed. Battle explains some of the science linking proper nutrition with relief from mental/emotional distress and offers suggestions for transitioning from poor diets (including the treats that we may use to placate children) to diets that promote physical and emotional well-being.

Effect Of Propionic Acid-Derivative Ibuprofen On Neural Stem Call Differentiation; A Potential Link To Autism Spectrum Disorder, Aseelia Samsam

Honors Undergraduate Theses

Propionic acid (PPA) is a short chain fatty acid that is produced by the human gut microbiome. Propionate, butyrate and acetates are the end products of the fermentation of the complex carbohydrates by human gut friendly microbiome and are being used as sources of energy in our body. PPA is used as a food preservative against molds in various daily products and has been implicated in the pathogenesis of autism. In a recent study we showed that PPA in human neuronal stem cell (NSC) culture increases the astrocyte population and decreases the neuronal number and increases the inflammatory cytokines. In …

Under The Needle: Understanding The Benefits And Misconceptions Of Vaccinations, Desmond Davis

Student Writing

By and large, medical and government institutions such as the CDC have been primarily responsible for educating the public on the necessities of vaccinations, and quelling fears regarding them. As the world becomes more connected, proponents of the anti-vaccination movement find common ground via social media platforms and other outlets from which to confirm preexisting notions that vaccines are detrimental to recipients. This places a burden on both the aforementioned institutions as well as the general public to deal with potential outbreaks before they either resurge from previously low infectivity rates, or before they reach epidemic proportions.

The Link Between Vaccination And Autism, Erika Tellez

Student Writing

Vaccination provides individuals with protection against many preventable diseases, yet many claims against vaccination have causes vaccination rates to drop. Vaccination rates have dropped after a claim that vaccines offset autism was published. Although vaccination is necessary in order to prevent the spread of diseases throughout the population and in order to protect individuals who cannot be vaccinated. The claim that there is a link between vaccines and autism has been disproven based on lack of communication between the scientific community and public, discovery of falsified evidence, and further studies which demonstrate there is no link.

Autism And Vaccines: Exploring Misperceptions In Science, Arsenio Menendez

Student Writing

This paper will be exploring the supposed link between vaccines and autism which is a hot button topic as of late. Starting at the roots of where this myth began with the infamous and long since disproved initial paper penned by Andrew Wakefield. As of late with the ever-rising numbers of parents deciding to forego the vaccination of their children there is an increasing risk of herd immunity failing leading to old diseases that had been wiped out making a massive resurgence. Detailed in my research findings will be data driven explorations of psychology and human nature changing perception of …

Using Parent-Identified Strengths Of Autistic Children To Advance Strength-Based Intervention, Angelique Francesca Trigueros

Walden Dissertations and Doctoral Studies

Questions remain about the range of abilities autistic children possess and what constitutes effective treatment. Strength-based intervention contrasts with traditional autistic intervention approaches that focus on children's deficits. Studies on strength-based intervention approaches have not revealed how children's strengths are identified and have not used the insights of parents for this purpose. Neurodiversity serves as the conceptual framework because the tenets of neurodiversity align with those of strength-based approaches and hold that autism is a variation of the human condition rather than a disability. The purpose of this qualitative interpretive phenomenological study was to explore how the parent-identified strengths of …

Blunted Serum 25(Oh)D Response To Vitamin D3 Supplementation In Children With Autism, Conor Kerley, Basil Elnazir, Peter Greally, David Coghlan

Articles

Introduction: Data suggest a potential role for vitamin D in autism spectrum disorder (ASD) prevention and treatment. It is likely that the serum response to vitamin D supplementation contributes to its effectiveness. Multiple factors affect serum vitamin D 25(OH)D response to supplementation.

Methods: We conducted post-hoc analysis of two double-blind, randomized, placebo-controlled trials (RCT) of vitamin D3 supplementation, one RCT involving children with ASD and another involving children with asthma. Both trials were conducted in the same geographic location (Dublin, Ireland, 53°N), conducted over Winter season and utilized the same vitamin D3 dose (2000 IU/day).

Results: We …

Alternative Interventions For Children Coping With Chronic Conditions: A Critical Review Of The Literature, Nina M. Pelsi, Kim S. Amer

DePaul Discoveries

Reduction of stressors and anxiety levels in adolescents with chronic illnesses is a critical concept in pediatric health care in America today. The many stressors associated with chronic illness include displaying physical and mental differences, social stigma, financial difficulty, and family stress. These stressors may affect the adolescent’s ability to learn and cope in everyday life. The current research was a critical review of the literature examining studies done with adolescents coping with chronic diseases and illnesses. The aim was to analyze the most efficacious non-pharmacological methods for reducing stressors in adolescents with chronic illness. A critical review of the …

Interactive Physical And Cognitive Exercise System (Ipaces™): The Neuropsychological Effects For Youth On The Autism Spectrum, Michaela Haller

Honors Theses

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that affects 1 in 68 children in the United States (Center for Disease Control, 2016). The disorder is characterized by deficits in social interaction, verbal communication, restricted interests, and repetitive behaviors (DSM- V, 2013). While the apparent cause of ASD is biological, the diagnosis remains based on social deficits (Hapé & Frith, 1996). Exercise has been found to improve executive function for children with an Autism Spectrum Disorder, but motivation is an issue and exergames hold promise. This pilot study evaluated an interactive Physical and Cognitive Exercise System (iPACES™), wherein children pedal …

Characterizing Food Selectivity In Children With Autism, Samantha H. Wohlmacher

Honors Theses and Capstones

Food selectivity or “picky eating” affects a large percentage of children on the autism spectrum and as a result can have negative impacts on a child’s health and nutritional status (Cermak, Curtin, & Bandini, 2010). Few studies compare food selectivity in children on the autism spectrum to children with other developmental issues. Such a comparison may reveal how food selectivity presents itself uniquely in children on the autism spectrum. This study examined data from past health records collected from the Seacoast Childhood Development Center (SCDC). Thirty-eight children whose parents were concerned about their diets were taken from a larger sample …

Funciones Sensoriales En Niños Menores De 3 Años Diagnosticados Con Trastorno Del Espectro Autista (Tea) / Sensory Processing In Toddlers Diagnosed With Autism Spectrum Disorder (Asd), Juliana Gutiérrez, Megan Chang, Erna Imperatore Blanche

Faculty Research, Scholarly, and Creative Activity

Spanish: Las dificultades de procesamiento sensorial en niños con Trastorno del Espectro Autista (TEA) están ampliamente descritos en la literatura principalmente mediante el uso de encuestas a padres y observaciones. Con menor frecuencia se han descrito las dificultades de procesamiento sensorial en niños menores de 3 años de edad que han sido posteriormente diagnosticados con TEA. Este studio retrospectivo está basado en 84 niños (28 diagnosticados con TEA, 28 con retraso en el desarrollo, y 28 niños con desarrollo típico) entre 18 y 36 meses de edad que asistieron a un programa de intervención temprana y cuyos padres completaron el …

Neuroanatomical Alterations In High-Functioning Adults With Autism Spectrum Disorder, Tehila Eilam-Stock, Tingting Wu, Alfredo Spagna, Laura J. Egan, Jin Fan

Publications and Research

Autism spectrum disorder (ASD) is a pervasive neurodevelopmental condition, affecting cognition and behavior throughout the life span. With recent advances in neuroimaging techniques and analytical approaches, a considerable effort has been directed toward identifying the neuroanatomical underpinnings of ASD. While gray-matter abnormalities have been found throughout cortical, subcortical, and cerebellar regions of affected individuals, there is currently little consistency across findings, partly due to small sample-sizes and great heterogeneity among participants in previous studies. Here, we report voxel-based morphometry of structural magnetic resonance images in a relatively large sample of high-functioning adults with ASD (n = 66) and matched …