Medicine and Health Sciences Commons^™

Identification Of A Rickettsial Endosymbiont In A Soft Tick Ornithodoros Turicata Americanus, Lichao Liu, Daniel E. Sonenshine, Hameeda Sultana, Girish Neelakanta

Biological Sciences Faculty Publications

Bacterial endosymbionts are abundantly found in both hard and soft ticks. Occidentia massiliensis, a rickettsial endosymbiont, was first identified in the soft tick Ornithodoros sonrai collected from Senegal and later was identified in a hard tick Africaniella transversale. In this study, we noted the presence of Occidentia species, designated as Occidentia-like species, in a soft tick O. turicata americanus. Sequencing and phylogenetic analyses of the two genetic markers, 16S rRNA and groEL confirmed the presence of Occidentia-like species in O. turicata americanus ticks. The Occidentia-like species was noted to be present in all developmental stages …

Serological Proteomic Screening And Evaluation Of A Recombinant Egg Antigen For The Diagnosis Of Low-Intensity Schistosoma Mansoni Infections In Endemic Area In Brazil, Vanessa Silva-Moraes, Lisa Marie Shollenberger, William Castro-Borges, Ana Lucia Teles Rabello, Donald A. Harn, Lia Carolina Soares Medeiros, Wander De Jesus Jeremias, Liliane Maria Vidal Siqueira, Caroline Stephane Salviano Pereira, Maria Luysa Camargos Pedrosa, Nathalie Bonatti Franco Almeida, Aureo Almeida, Jose Roberto Lambertucci, Nidia Francisca De Figueiredo Carneiro, Paulo Marcos Zech Coelho, Refaella Fortini Queiroz Grenfell

Biological Sciences Faculty Publications

Background

Despite decades of use of control programs, schistosomiasis remains a global public health problem. To further reduce prevalence and intensity of infection, or to achieve the goal of elimination in low-endemic areas, there needs to be better diagnostic tools to detect low-intensity infections in low-endemic areas in Brazil. The rationale for development of new diagnostic tools is that the current standard test Kato-Katz (KK) is not sensitive enough to detect low-intensity infections in low-endemic areas. In order to develop new diagnostic tools, we employed a proteomics approach to identify biomarkers associated with schistosome-specific immune responses in hopes of developing …

The Coexistence Of Heart Murmurs And Arrhythmias In An Equine Hospital Population ? A Retrospective Study, Ali̇ Cesur Onmaz, Vehbi̇ Güneş, Alexandra Pavaloiu, René Van Den Hoven

Turkish Journal of Veterinary & Animal Sciences

This study was performed to characterize the coexistence of valvar insufficiencies of the mitral, tricuspid, aortic, and pulmonary valves and their possible association with atrial fibrillation in an equine clinic population. During an 11-year period, 348 horses had been examined for cardiac arrhythmias and suspected defects of the cardiac valves at the Vetmeduni Vienna, Austria. The study population included 256 male and 92 female horses. A subpopulation of 197 (57%) horses was identified with at least one valvular disorder. In these horses, mitral valve regurgitation (MR) was reported in 124 animals (63%), aortic valve regurgitation (AR) in 101 (51%), tricuspid …

Data Publication With The Structural Biology Data Grid Supports Live Analysis, Peter A. Meyer, Stephanie Socias, Jason Key, Elizabeth Ransey, Emily C. Tjon, Alejandro Buschiazzo, Ming Lei, Chris Botka, James Withrow, David Neau, Kanagalaghatta Rajashankar, Karen S. Anderson, Richard H. Baxter, Stephen C. Blacklow, Titus J. Boggon, Alexandre M. J. J. Bonvin, Dominika Borek, Tom J. Brett, Amedeo Caflisch, Chung-I Chang, Walter J. Chazin, Kevin D. Corbett, Michael S. Cosgrove, Sean Crosson, Sirano Dhe-Paganon, Enrico Di Cera, Catherine L. Drennan, Michael J. Eck, Brandt F. Eichman, Qing R. Fan, Oleg V. Tsodikov

Pharmaceutical Sciences Faculty Publications

Access to experimental X-ray diffraction image data is fundamental for validation and reproduction of macromolecular models and indispensable for development of structural biology processing methods. Here, we established a diffraction data publication and dissemination system, Structural Biology Data Grid (SBDG; data.sbgrid.org), to preserve primary experimental data sets that support scientific publications. Data sets are accessible to researchers through a community driven data grid, which facilitates global data access. Our analysis of a pilot collection of crystallographic data sets demonstrates that the information archived by SBDG is sufficient to reprocess data to statistics that meet or exceed the quality of the …

Personality And Religious Values Among Adolescents: A Three-Wave Longitudinal Analysis., Patrick C. Heaven, Joseph V. Ciarrochi

joseph Ciarrochi

Using three waves of data, we assessed the relationships between endorsement of religious values, some of the major personality dimensions, and social and emotional well-being amongst teenagers. Participants were 784 high school students at Time 1 (382 manles and 394 females; 8 did not indicate their gender) and 563 provided data at each of Time 1, Time 2 and Time 3.

Self-Nominated Peer Crowds, School Achievement, And Psychological Adjustment In Adolescents: Longitudinal Analysis, Patrick Heaven, Joseph Ciarrochi, Wilhelmina Vialle

joseph Ciarrochi

No abstract provided.

Perceptions Of Parental Styles And Eysenckian Psychoticism In Youth: A Prospective Analysis, Patrick Heaven, Joseph Ciarrochi

joseph Ciarrochi

No abstract provided.

Identification Of A Family Of Fatty Acid-Speciated Sonic Hedgehog Proteins, Whose Members Display Differential Biological Properties, Jun Long, Robert Tokhunts, William M. Old, Stephane Houel, Jezabel Rodgriguez-Blanco, Samer Singh, Neal Schilling, Anthony J. Capobianco, Natalie G. Ahn, David J. Robbins

Dartmouth Scholarship

Hedgehog (HH) proteins are proteolytically processed into a biologically active form that is covalently modified by cholesterol and palmitate. However, most studies of HH biogenesis have characterized protein from cells in which HH is overexpressed. We purified Sonic Hedgehog (SHH) from cells expressing physiologically relevant levels and showed that it was more potent than SHH isolated from overexpressing cells. Furthermore, the SHH in our preparations was modified with a diverse spectrum of fatty acids on its amino termini, and this spectrum of fatty acids varied dramatically depending on the growth conditions of the cells. The fatty acid composition of SHH …

Muscles Within Muscles: A Mechanomyographic Analysis Of Muscle Segment Contractile Properties Within Human Gluteus Maximus, Darryl Mcandrew, John Brown, Mark Gorelick

Darryl J McAndrew

No abstract provided.

Evaluation Of The Power And Type 1 Error Of Recently Proposed Family-Based Tests Of Assocations For Rare Variants, Allison Hainline, Carolina Alvarez, Alexander Luedtke, Brian Greco, Andrew Beck, Nathan L. Tintle

Faculty Work Comprehensive List

Until very recently, few methods existed to analyze rare-variant association with binary phenotypes in complex pedigrees. We consider a set of recently proposed methods applied to the simulated and real hypertension phenotype as part of the Genetic Analysis Workshop 18. Minimal power of the methods is observed for genes containing variants with weak effects on the phenotype. Application of the methods to the real hypertension phenotype yielded no genes meeting a strict Bonferroni cutoff of significance. Some prior literature connects 3 of the 5 most associated genes (p <1 × 10−4) to hypertension or related phenotypes. Further methodological development is needed to extend these methods to handle covariates, and to explore more powerful test alternatives.

Application Of Family-Based Tests Of Association For Rare Variants To Pathways, Brian Greco, Alexander Luedtke, Allison Hainline, Carolina Alvarez, Andrew Beck, Nathan L. Tintle

Faculty Work Comprehensive List

Pathway analysis approaches for sequence data typically either operate in a single stage (all variants within all genes in the pathway are combined into a single, very large set of variants that can then be analyzed using standard “gene-based” test statistics) or in 2-stages (gene-based p values are computed for all genes in the pathway, and then the gene-based p values are combined into a single pathway p value). To date, little consideration has been given to the performance of gene-based tests (typically designed for a smaller number of single-nucleotide variants [SNVs]) when the number of SNVs in the gene …

Newspaper Coverage Of Drug Policy: An Analysis Of Pre-Election Reporting Of The Greens' Drug Policy In Australia, Danika Hall, Sandra C. Jones, Fiona Cowlin

Sandra Jones

Introduction and Aims. With the headline 'Ecstasy Over The Counter' in a popular daily newspaper, the debate on drug policy officially entered the arena of the 2003 New South Wales (Australia) State Election. The debate resurfaced in the lead-up to the 2004 Australian Federal Election. This paper analyses the pre-election coverage of drug policy issues in four Australian newspapers. Design and Methods. Four high-circulation daily newspapers were monitored for a one-month period prior to both elections and analysed for their coverage of drug policy, particularly with respect to the policy of the Greens. Results. The newspapers took different perspectives on …

Disease Awareness Advertisements In Australian Magazines: An Analysis Of Content And Compliance, Danika Hall, Sandra C. Jones, Donald C. Iverson

Sandra Jones

In Australia, Direct to Consumer Advertising (DTCA) of prescription medicine is prohibited; however pharmaceutical companies can communicate directly with consumers via Disease Awareness Advertising (DAA). DAA can contain information about a disease including treatment information, but cannot mention the name of a particular product or brand. DAA is currently regulated by the industry body Medicines Australia (MA). In the current study, content analysis methodology was used to determine the extent and nature of DAA in popular Australian women’s magazines which were monitored for 12 months. Findings relating to the use of visual appeals in the imagery and rational appeals in …

Patent Landscape Of Helminth Vaccines And Related Technologies, Jon R. Cavicchi, Stanley P. Kowalski, John Schroeder, Rayna Burke, Jillian Michaud-King

Law Faculty Scholarship

Executive Summary This report focuses on patent landscape analysis of technologies related to vaccines targeting parasitic worms, also known as helminths. These technologies include methods of formulating vaccines, methods of producing of subunits, the composition of complete vaccines, and other technologies that have the potential to aid in a global response to this pathogen. The purpose of this patent landscape study was to search, identify, and categorize patent documents that are relevant to the development of vaccines that can efficiently promote the development of protective immunity against helminths. The search strategy used keywords which the team felt would be general …

Analysis Of The Costs Of A Large Prevention Trial, Nicole Urban, Steven Self, Larry Kessler, Ross Prentice, Maureen Henderson, Donald Iverson, Donovan Thompson, David Byar, William Insull, Sherwood Gorbach, C Clifford, Susan Goldman

Don C. Iverson

Total direct costs of the Women's Health Trial (WHT), alarge multicenter preventiontrial, were reduced by more than 50% by means of research costanalysis conducted during the trial design phase. The unit costs of specific trial activities were estimated so that total direct costs of the trial could be predicted from design parameters. The relative costs of screening, treatment, and follow-up, and the fixed costs associated with each clinical center in a multicenter preventiontrial were taken into account. Direct costs of the WHT were reduced from $195 million to $95 million by refinement of the trial protocol, selection of an efficient …

An Overview And Analysis Of The Health Style Campaign, Mary Davis, Donald Iverson

Don C. Iverson

In 1981, the Office of Health Information and Health Promotion of the U.S. Department of Health and Human Services launched a national health promotion media campaign titled Health Style. The purposes of the Health Style campaign were: (1) to increase public awareness of the effects of life-style on health; (2) to enable persons to assess which life-style changes would be most conducive to their health; (3) to stimulate information-seeking behavior and; (4) to foster the development of local health promotion activities and referral networks. The campaign was implemented in nine test communities across the United States. This article: (1) provides …

Disease Awareness Advertisements In Australian Magazines: An Analysis Of Content And Compliance, Danika Hall, Sandra C. Jones, Donald C. Iverson

Don C. Iverson

In Australia, Direct to Consumer Advertising (DTCA) of prescription medicine is prohibited; however pharmaceutical companies can communicate directly with consumers via Disease Awareness Advertising (DAA). DAA can contain information about a disease including treatment information, but cannot mention the name of a particular product or brand. DAA is currently regulated by the industry body Medicines Australia (MA). In the current study, content analysis methodology was used to determine the extent and nature of DAA in popular Australian women’s magazines which were monitored for 12 months. Findings relating to the use of visual appeals in the imagery and rational appeals in …

Content Analysis Of Disease Awareness Advertisements In Popular Australian Women's Magazines, Danika V. Hall, Sandra C. Jones, Donald C. Iverson

Don C. Iverson

Objective: To examine the nature of disease awareness advertising (DAA). Design: Therapeutic advertisements in six popular Australian women’s magazines were monitored between April 2006 and March 2007. A subset of advertisements was included in the study based on criteria derived from a definition of DAA. Unique advertisements were analysed by four independent coders. Main outcome measures: Types of advertisements and their sponsors, the types of disease information present, and the persuasive techniques utilised. Results: Of 711 advertisements identified, 60 met the inclusion criteria for DAA, and 30 of these were unique. Over one-third of the advertisements were classified as “unbranded …

Clinician Optimism: Development And Psychometric Analysis Of A Scale For Mental Health Clinicians, Mitchell K. Byrne, Nichole L. Sullivan, Stephen J. Elsom

Mitchell K Byrne

Clinician optimism is an important factor in achieving treatment outcomes in psychotherapy. Currently there are no measures of mental health clinician optimism which report substantial psychometric validation. This study sought to assesses the validity and reliability of the Therapeutic Optimism Scale (TOS). 223 mental health clinicians working in a range of clinical settings were administered the TOS and convergent and discriminate validity were established. Test-retest reliability was established over a period of one month. The Therapeutic Optimism Scale was found to achieve acceptable reliability (Chronbach's alpha = .68) and yielded consistent scores over a one month period (r = .68, …

Essays In Realism: Analysis And Discussion, Nigel Mackay, Agnes Petocz

Nigel Mackay

No abstract provided.

Fish Consumption And Chd Mortality: An Updated Meta-Analysis Of Seventeen Cohort Studies, Jusheng Zheng, Tao Huang, Yinghua Yu, Xiaojie Hu, Bin Yang, Duo Li

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective Results of studies on fish consumption and CHD mortality are inconsistent. The present updated meta-analysis was conducted to investigate the up-to-date pooling effects. Design A random-effects model was used to pool the risk estimates. Generalized least-squares regression and restricted cubic splines were used to assess the possible dose–response relationship. Subgroup analyses were conducted to examine the sources of heterogeneity. Setting PubMed and ISI Web of Science databases up to September 2010 were searched and secondary referencing qualified for inclusion in the study. Subjects Seventeen cohorts with 315 812 participants and average follow-up period of 15·9 years were identified. Results …

Are Parents' Working Patterns Associated With Their Child's Sleep? An Analysis Of Dual-Parent Families In Australia, Christopher A. Magee, Peter Caputi, Don C. Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Insufficient sleep in children predicts emotional and behavioral problems, poorer school performance, and health problems. Child sleep durations have declined in recent decades, suggesting a need to identify and understand predictors of short sleep. The present study investigated whether aspects of parental employment (i.e. parental work hours, and non-standard work hours) were associated with sleep in children. Data collected from 2477 children aged 6–7 years as part of the Longitudinal Study of Australian Children were used in this paper. Child sleep duration, bedtimes, and wake times were determined from parent self-report using time-use diaries. Parents completed a survey assessing their …

The Challenges And Opportunities For Professional Societies In Higher Education In Australasia: A Pest Analysis, Iain Doherty, Caroline Steel, Dominique Parrish

Faculty of Health and Behavioural Sciences - Papers (Archive)

Professional societies, established to support academic and professional staff in higher education, need to be vigilant of regional and international trends that affect their core business. In this paper, we provide an analysis of political, economic, social and technological factors that are impacting upon the Australasian higher education environment through considering the case of the Australasian Society for Computers in Learning in Tertiary Education (ascilite). Drawing on two ascilite membership surveys along with the relevant literature we identify significant challenges for professional societies and offer some strategic insights for similar regional societies and their executive teams.

Healthy Beginnings Trial Phase 2 Study: Follow-Up And Cost-Effectiveness Analysis, Li Ming Wen, Louise A. Baur, Chris Rissel, Vicki Flood, Judy M. Simpson, Alison Hayes, Louise L. Hardy, Karen Wardle

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background: In 2007, we commenced the Healthy Beginnings Trial (HBT) Phase 1 study, which is the first randomised controlled trial (RCT) to test the effectiveness of an early childhood obesity intervention in children aged up to 2 years. The results were promising with significant improvements in infant feeding practices and a lower mean body mass index (BMI). The aims of this proposed Phase 2 study are to determine if the early intervention will lead to a lower mean BMI, lower screen time, improved dietary behaviours and demonstrated costeffectiveness of the intervention, in children aged 3½ and 5 years. Methods/design: In …

Barriers And Enablers To Implementation Of A New Zealand-Wide Guideline For Assessment And Management Of Cardiovascular Risk In Primary Health Care: A Template Analysis, Ann Mckillop, Jackie Crisp, Kenneth Walsh

Faculty of Health and Behavioural Sciences - Papers (Archive)

Aim: The aim of this study was to identify the enablers and barriers to guideline implementation in a primary healthcare setting by employing the Promoting Action on Research Implementation in Health Services (PARIHS) framework as a template for data analysis and interpretation. Background: The use of clinical practice guidelines is pivotal to improving health outcomes. However, the implementation of guidelines into practice is complex, unpredictable, and, in spite of much investigation, remains resistant to explanation of what works and why. Optimising the enablers and minimising the barriers to implementation of a guideline for reducing cardiovascular disease risk has the potential …

The Impact Of Cannabis Use On Cognitive Functioning In Patients With Schizophrenia: A Meta-Analysis Of Existing Findings And New Data In A First-Episode Sample, Murat Yücel, Emre Bora, Daniel I. Lubman, Nadia Solowij, Warrick J. Brewer, Sue M. Cotton, Phillipe Conus, Michael J. Takagi, Alex Fornito, Stephen J. Wood, Patrick D. Mcgorry, Christos Pantelis

Faculty of Health and Behavioural Sciences - Papers (Archive)

Cannabis use is highly prevalent among people with schizophrenia, and coupled with impaired cognition, is thought to heighten the risk of illness onset. However, while heavy cannabis use has been associated with cognitive deficits in long-term users, studies among patients with schizophrenia have been contradictory. This article consists of 2 studies. In Study I, a meta-analysis of 10 studies comprising 572 patients with established schizophrenia (with and without comorbid cannabis use) was conducted. Patients with a history of cannabis use were found to have superior neuropsychological functioning. This finding was largely driven by studies that included patients with a lifetime …

Essays In Realism: Analysis And Discussion, Nigel Mackay, Agnes Petocz

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

A Meta-Analysis Of Response Inhibition And Stroop Interference Control Deficits In Adults With Traumatic Brain Injury (Tbi), Aneta Dimoska-Di Marco, Skye Mcdonald, Michelle Kelly, Robyn Tate, Stuart Johnstone

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

Content Analysis Of Disease Awareness Advertisements In Popular Australian Women's Magazines, Danika V. Hall, Sandra C. Jones, Donald C. Iverson

Sandra Jones

Objective: To examine the nature of disease awareness advertising (DAA). Design: Therapeutic advertisements in six popular Australian women’s magazines were monitored between April 2006 and March 2007. A subset of advertisements was included in the study based on criteria derived from a definition of DAA. Unique advertisements were analysed by four independent coders. Main outcome measures: Types of advertisements and their sponsors, the types of disease information present, and the persuasive techniques utilised. Results: Of 711 advertisements identified, 60 met the inclusion criteria for DAA, and 30 of these were unique. Over one-third of the advertisements were classified as “unbranded …

Plant Phenolics: Extraction, Analysis And Their Antioxidant And Anticancer Properties, Jin Dai, Russell J. Mumper

Pharmaceutical Sciences Faculty Publications

Phenolics are broadly distributed in the plant kingdom and are the most abundant secondary metabolites of plants. Plant polyphenols have drawn increasing attention due to their potent antioxidant properties and their marked effects in the prevention of various oxidative stress associated diseases such as cancer. In the last few years, the identification and development of phenolic compounds or extracts from different plants has become a major area of health- and medical-related research. This review provides an updated and comprehensive overview on phenolic extraction, purification, analysis and quantification as well as their antioxidant properties. Furthermore, the anticancer effects of phenolics in-vitro …