Medicine and Health Sciences Commons^™

Development Of A Novel Screening Strategy Designed To Discover A New Class Of Hiv Drugs, Nancy Cheng, Sook-Kyung Lee, P. Donover, Mel Reichman, Celia Schiffer, Emily Hull-Ryde, Ronald Swanstrom, William Janzen

Celia A. Schiffer

Current antiretroviral treatments target multiple pathways important for human immunodeficiency virus (HIV) multiplication, including viral entry, synthesis and integration of the DNA provirus, and the processing of viral polyprotein precursors. However, HIV is becoming increasingly resistant to these "combination therapies." Recent findings show that inhibition of HIV Gag protein cleavage into its two structural proteins, matrix (MA) and capsid (CA), has a devastating effect on viral production, revealing a potential new target class for HIV treatment. Unlike the widely used HIV protease inhibitors, this new class of inhibitor would target the substrate, not the protease enzyme itself. This approach offers …

Interview With Celia Schiffer, Celia Schiffer

Celia A. Schiffer

Celia Schiffer, a Professor in Biochemistry and Molecular Pharmacology; a former Director of UMass Center for AIDS Research; and a Founder and Co-Director for the Institute for Drug Resistance (University of Massachusetts Medical School, MA, USA). Schiffer has an undergraduate degree in physics from the University of Chicago, with a PhD in biophysics from University of California, San Francisco (CA, USA). She was a postdoctoral associate first at the ETH in Zurich and then at Genentech in San Francisco. Schiffer has published more than 100 peer reviewed journal articles. Her laboratory primarily uses structural biology, biophysical and chemistry techniques to …

Prototypical Recombinant Multi-Protease Inhibitor Resistant Infectious Molecular Clones Of Human Immunodeficiency Virus Type-1, Vici Varghese, Yumi Mitsuya, W. Jeffrey Fessel, Tommy F. Liu, George Melikian, David Katzenstein, Celia Schiffer, Susan Holmes, Robert Shafer

Celia A. Schiffer

The many genetic manifestations of HIV-1 protease inhibitor (PI) resistance present challenges to research into the mechanisms of PI-resistance and the assessment of new PIs. To address these challenges, we created a panel of recombinant multi-PI resistant infectious molecular clones designed to represent the spectrum of clinically relevant multi-PI resistant viruses. To assess the representativeness of this panel, we examined the sequences of the panel's viruses in the context of a correlation network of PI-resistance amino acid substitutions in sequences from more than 10,000 patients. The panel of recombinant infectious molecular clones comprised 29 of 41 study-defined PI-resistance amino acid …

Collaboration In Sport Research: A Case From The Field, Corinne Daprano, Jennifer Bruening, Donna Pastore, T. Greenwell, Marlene Dixon, Yong Ko, Jeremy Jordan, Sonja Lilienthal, Brian Turner

Corinne M. Daprano

Faculty members mindful of the ticking tenure and promotion clock seek ways to balance the competing and sometimes overwhelming demands of research, teaching, and service. One way to balance these demands is to find opportunities for collaboration with colleagues, especially in research. There are several compelling reasons to pursue joint research projects with colleagues; however, collaboration can be challenging. This article discusses the benefits and challenges of working on collaborative research projects with colleagues from the same discipline as well as across disciplines.

Protecting Your Back: Weight Room Management, Peter Titlebaum, Gordon Rackley

Peter J. Titlebaum

Weight room supervision can be a formidable undertaking without the necessary preparations and precautions. Weight room supervisors are much like the Secret Service; that is, no matter what happens, if bad, it is the supervisor's fault. Risk management is more important now than at any point in history. The keys to preventing problems and creating an efficient weight room facility include a highly trained staff and a thoroughly detailed employee manual designed specifically for the weight room.

Hazing: What Ohio High School Teachers, Coaches And Administrators Need To Know, Corinne Daprano, Meghan Kenney, Peter Titlebaum, Michael Triola

Peter J. Titlebaum

Once thought to be primarily an issue of concern for university fraternities and sororities, hazing has emerged as a disturbing trend with an increase in the number of incidents involving high school student athletes. High school coaches, athletic administrators, and teachers must understand that initiation rites of sport teams can sometimes spiral out of control with grave legal and financial consequences for student athletes and school officials. The purposes of this article are to:

• Define hazing and review the history of anti-hazing legislation in the United States of America.

• Describe hazing laws in the State of Ohio.

• Review current research …

Dysfunctional Conformational Dynamics Of Protein Kinase A Induced By A Lethal Mutant Of Phospholamban Hinder Phosphorylation, Jonggul Kim, Larry R. Masterson, Alessandro Cembran, Raffaello Verardi, Lei Shi, Jiali Gao, Susan S. Taylor, Gianluigi Veglia

Larry Masterson