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Full-Text Articles in Medicine and Health Sciences
Materials And Methods Developed For The Recording And Analysis Of Behavior In The Common Marmoset (Callithrix Jacchus)., Christian Wintle
Materials And Methods Developed For The Recording And Analysis Of Behavior In The Common Marmoset (Callithrix Jacchus)., Christian Wintle
UNO Student Research and Creative Activity Fair
Materials and methods developed for the recording and analysis of behavior in the common marmoset (Callithrix jacchus).
Christian J. Wintlea, Jordan B. Hernandeza,b,c, Dobromir Dotovd, and Jonathan B. Claytona,b,e,f,g
aDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA
bNebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, USA
cDepartment of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, NE, USA
dDepartment of Biomechanics, University of Nebraska at Omaha, Omaha, NE, USA
eDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, …
Accelerometry-Based Analysis Of Postural Sway In Parkinson's Disease Patients With Levodopa-Induced Dyskinesia, Chandler Brock
Accelerometry-Based Analysis Of Postural Sway In Parkinson's Disease Patients With Levodopa-Induced Dyskinesia, Chandler Brock
UNO Student Research and Creative Activity Fair
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, with patient numbers projected to double to 12 million in the next 20 years. Levodopa-induced dyskinesia (LID) is a major problem associated with the long-term use of levodopa for symptomatic treatment of PD. These involuntary movements can become disabling and may interfere with quality of life. Our prior research showed that PD w/ LID were less stable while standing (i.e., increased postural sway) and had a higher incidence of falls. The aim of this study is to determine if postural sway properties are altered by LID via decomposing the sway signal. We …
The Effects Of Demographics And Risk Factors On The Morphological Characteristics Of Human Femoropopliteal Arteries, Sayed Ahmadreza Razian, Majid Jadidi, Alexey Kamenskiy
The Effects Of Demographics And Risk Factors On The Morphological Characteristics Of Human Femoropopliteal Arteries, Sayed Ahmadreza Razian, Majid Jadidi, Alexey Kamenskiy
UNO Student Research and Creative Activity Fair
Background: Disease of the lower extremity arteries (Peripheral Arterial Disease, PAD) is associated with high morbidity and mortality. During disease development, the arteries adapt by changing their diameter, wall thickness, and residual deformations, but the effects of demographics and risk factors on this process are not clear.
Methods: Superficial femoral arteries from 736 subjects (505 male, 231 female, 12 to 99 years old, average age 51±17.8 years) and the associated demographic and risk factor variables were used to construct machine learning (ML) regression models that predicted morphological characteristics (diameter, wall thickness, and longitudinal opening angle resulting from the …
Effect Of Dual Tasking And Levodopa-Induced Dyskinesia On Postural Sway In People With Parkinson's Disease, Joseph Ayotunde Aderonmu, Carolin Curtze
Effect Of Dual Tasking And Levodopa-Induced Dyskinesia On Postural Sway In People With Parkinson's Disease, Joseph Ayotunde Aderonmu, Carolin Curtze
UNO Student Research and Creative Activity Fair
Parkinson's disease (PD) is a neurodegenerative disorder that results in motor impairments such as gait and balance deficits. Levodopa is one of the most effective drugs in treating the slowness of movement in individuals with PD. However, the long-term use of levodopa in treating PD often causes undesirable involuntary and uncontrollable movements, known as levodopa-induced dyskinesia (LID). LID is a known cause of increased postural sway. Yet, the relative contribution of the body segments often affected by dyskinesia to postural sway is unknown. We aimed to investigate the contribution of different body segments to postural sway in PD for individuals …
Design And Development Of Software With A Graphical User Interface To Display And Convert Multiple Microscopic Histology Images, Sayed Ahmadreza Razian, Majid Jadidi, Alexey Kamenskiy
Design And Development Of Software With A Graphical User Interface To Display And Convert Multiple Microscopic Histology Images, Sayed Ahmadreza Razian, Majid Jadidi, Alexey Kamenskiy
UNO Student Research and Creative Activity Fair
Histological images are widely used to assess the microscopic anatomy of biological tissues. Recent advancements in image analysis allow the identification of structural features on histological sections that can help advance medical device development, brain and cancer research, drug discovery, vascular mechanobiology, and many other fields. Histological slide scanners create images in SVS and TIFF formats that were designed to archive image blocks and high-resolution textual information. Because these formats were primarily intended for storage, they are often not compatible with conventional image analysis software and require conversion before they can be used in research. We have developed a user-friendly …
Breaks In Longitudinal Elastic Fibers Of Human Femoropopliteal Arteries, Elham Zamani
Breaks In Longitudinal Elastic Fibers Of Human Femoropopliteal Arteries, Elham Zamani
UNO Student Research and Creative Activity Fair
Breaks in Longitudinal Elastic Fibers of Human Femoropopliteal Arteries
Elham Zamani1, Majid Jadidi1
1 Department of Biomechanics, University of Nebraska Omaha, Omaha, NE
Introduction: Elastin is a major protein in the body with half-life >50 years. It is thought that elastic fibers are formed before the postnatal period. In the femoropopliteal artery (FPA), the main artery in the leg, longitudinal elastic fibers are present in External Elastic Lamina (EEL). Our team has studied more than 1000 cadaveric human FPA and has noticed that there are big breaks in their longitudinal elastic fibers in some subjects. Our goal in this work …
Ingredient Classification Using Food Ontology, Ricky Flores
Ingredient Classification Using Food Ontology, Ricky Flores
UNO Student Research and Creative Activity Fair
A food label provides some of the most crucial information for a food product. The food label is a key resource for many health-conscious consumers for understanding ingredients. It is also vital for individuals to avoid food allergens or help patients follow dietary recommendations. While the food labels in the United States are regulated by the Food and Drug Administration (FDA) many labels contain additional information or statements that are not regulated. Moreover, the food label may be complex or contain terminology that the layperson may not understand. Evidence has indicated that consumers often find nutrition labels confusing, especially when …
A Systematic Review: Long Range Correlations In Running Gait, Mr. Taylor Wilson
A Systematic Review: Long Range Correlations In Running Gait, Mr. Taylor Wilson
UNO Student Research and Creative Activity Fair
Long range correlations (LRCs) are apparent in human walking and running gait and are indicative of a healthy system. A systematic review (SR) was completed to determine the typical LRC patterns in running. 20 articles were included in the SR. LRCs in running gait tend to be similar to the LRCs in walking gait, with fatigue contributing to a negative effect on the LRCs.
This SR could have implications on training guidelines for coaches and physical therapy methods to increase the LRCs in running gait for healthier functioning. More research is needed to determine how LRCs depend on running surface …
Impacts Of Mitoquinol Mesylate Intake On Vascular Function And Cognitive Impairment In Patients With Mild Cognitive Impairment: A Case Study, Lindie Strickler
Impacts Of Mitoquinol Mesylate Intake On Vascular Function And Cognitive Impairment In Patients With Mild Cognitive Impairment: A Case Study, Lindie Strickler
UNO Student Research and Creative Activity Fair
Mild cognitive impairment (MCI) is a decline in cognitive function to a greater extent than natural aging. It has been suggested that reduced brain blood flow is strongly associated with reduced cognitive function and neurodegenerative diseases, of which is partially attributed to excessive reactive oxygen species (ROS) production. Mitoquinol mesylate has been shown to scavenge ROS and improve vascular function in healthy older adults. However, the effects of mitoquinol in MCI patients have not been investigated.
Purpose: to elucidate the impacts of mitoquinol intake on vascular endothelial function (flow-mediated dilation, FMD), arterial stiffness (pulse-wave velocity, PWV), and cognitive function in …
How The Foot Modulates Its Mechanics During Uphill And Downhill Walking, Jeffrey M. Patterson, Kota Z. Takahashi
How The Foot Modulates Its Mechanics During Uphill And Downhill Walking, Jeffrey M. Patterson, Kota Z. Takahashi
UNO Student Research and Creative Activity Fair
The foot's biomechanical role in walking on sloped surfaces is currently unclear. While previous biomechanics studies have examined the hip, knee, and ankle, the foot is oversimplified as a rigid-body segment. This oversimplification overshadows its complex structure and function. In this project, we use an innovative multi-segment foot model to explore how the foot adapts its mechanics to incline and decline walking. Preliminary results have revealed that the foot is capable of adapting its mechanical work profile to both incline and decline walking. Specifically, the foot can increase its positive work output (i.e., increased energy generation) during inclined walking to …
Visual Contributions To Balance Control During Gait, Kyle Brozek
Visual Contributions To Balance Control During Gait, Kyle Brozek
UNO Student Research and Creative Activity Fair
We propose to isolate the contributions of continuous OF to the orthogonal relationship between balance and gait control during treadmill walking using a series of conditions. Manipulating the direction of OF using a CAREN (Motek Medical, Amsterdam, Netherlands) virtual reality treadmill environment will isolate these visual contributions in human subjects as they walk. We plan to tease out the effect of OF direction on the relationship between gait and balance control by having healthy young adults perform a series of treadmill walking trials while immersed in a VR environment. This will be done by manipulating the direction of walking and …
Impacts Of Exercise And Environmental Temperature On Mitochondrial Quantity And Quality, Halee Keller
Impacts Of Exercise And Environmental Temperature On Mitochondrial Quantity And Quality, Halee Keller
UNO Student Research and Creative Activity Fair
Halee Keller, Robert Shute, Dustin Slivka
University of Nebraska at Omaha, School of Health and Kinesiology, Omaha, NE
BACKGROUND: Mitochondria are highly concentrated in skeletal muscle tissue, and undergo damage from ROS during metabolic processes. This damage is often left unrepaired and leads to mitochondrial dysfunction, which has been linked to many common diseases. Exercise training increases mitochondrial development within skeletal muscle tissue and thus may be protective. Environmental temperature, when paired with exercise may provide an even greater effect than exercise alone. PURPOSE: The purpose of this study is to analyze the effects of three weeks of exercise …
The Effects Of Swimming Training On Arterial Stiffness, Muscular Strength And Cardiorespiratory Endurance In Postmenopausal Women With Stage 2 Hypertension, Steven Scott
UNO Student Research and Creative Activity Fair
Objective:
Aging is associated with progressive decreases in arterial health and function as well as overall fitness. It is crucial to prevent or reduce the negative effects of aging on vasculature and fitness components by implementing appropriate lifestyle interventions, such as exercise training. We examined the effects of a swimming (SWM) regimen on arterial stiffness (pulse wave velocity, PWV), blood pressure (BP), wave reflection (AIx), muscle strength and aerobic capacity in postmenopausal women with stage 2 hypertension.
Methods:
Using a parallel experimental design, participants were randomly assigned to either a SWM (n=52) or non-exercising control group (n=48) for 20 weeks. …
3d Prosthetics Effects On Standing Posture In Unilateral Upper Limb Deficient Children, Keaton Young
3d Prosthetics Effects On Standing Posture In Unilateral Upper Limb Deficient Children, Keaton Young
UNO Student Research and Creative Activity Fair
3D Prosthetics Effects on Standing Posture in Unilateral Upper Limb Deficient Children
Keaton Young
Department of Biomechanics, University of Nebraska at Omaha
Introduction
Upper Limb Reduction Deficiency (ULD) is a congenital disability that affects the upper limb, which the Center for Disease Control and Prevention estimates that nearly 1,500 babies are born with ULD in the United States yearly 1,2. Prior research has focused on functional treatment of the upper limbs but has lacked observance of the effects that prosthetics and limb loss incur to the trunk. Therefore, the purpose of this study is to examine the acute effects …
Studies Of Amino Acid Mutations In Drug Resistance Of The Smo Protein, Eunice Wintona
Studies Of Amino Acid Mutations In Drug Resistance Of The Smo Protein, Eunice Wintona
UNO Student Research and Creative Activity Fair
Smoothened receptor (SMO) is a protein that in humans, is encoded by the SMO gene. A systemic mutation in its binding pocket helps predict the sensitivity of mutant proteins to different drugs. Known as a GPCR-like receptor, it is a component of the hedgehog signaling pathway; a pathway involved in body patterning and the regulation of adult stem cells. An uncontrolled or inappropriate activation of the Hedgehog pathway drives tumor progression in cancers and a number of birth defects. To achieve these goals, the molecular modeling software MOE was used to build small molecules and drug molecules like Vismodegib and …
Docking Studies Of Isoform-Selectivity Of Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors, Kaitlin Goettsch
Docking Studies Of Isoform-Selectivity Of Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors, Kaitlin Goettsch
UNO Student Research and Creative Activity Fair
Phosphatidylinositol 3-kinases (PI3Ks) and their related pathways are reputed targets for drug-based anticancer therapies. Mutations in PI3K genes, expression, and pathways are frequent among multiple cancer types. Four isoforms of PI3Ks exist: α, β, γ, & δ and studies have identified several ligands for each isoform which are capable of serving as inhibitory therapeutic compounds. However, the biochemical efficacy of these molecules varies and the isoform selectivity is not well understood. In this study, we applied in silico docking methods and free energy calculation methods to estimate the binding of reported PI3K ligands against 5 PI3K structures: PI3Kα (PBD ID: …