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Full-Text Articles in Medicine and Health Sciences
The Role Of Alternative Splicing In The Control Of Immune Homeostasis And Cellular Differentiation, Mehmet Yabas, Hannah Elliott, Gerard F. Hoyne
The Role Of Alternative Splicing In The Control Of Immune Homeostasis And Cellular Differentiation, Mehmet Yabas, Hannah Elliott, Gerard F. Hoyne
Health Sciences Papers and Journal Articles
Alternative splicing of pre-mRNA helps to enhance the genetic diversity within mammalian cells by increasing the number of protein isoforms that can be generated from one gene product. This provides a great deal of flexibility to the host cell to alter protein function, but when dysregulation in splicing occurs this can have important impact on health and disease. Alternative splicing is widely used in the mammalian immune system to control the development and function of antigen specific lymphocytes. In this review we will examine the splicing of pre-mRNAs yielding key proteins in the immune system that regulate apoptosis, lymphocyte differentiation, …
Mechanisms That Regulate Peripheral Immune Responses To Control Organ Specific Autoimmunity, Gerard F. Hoyne
Mechanisms That Regulate Peripheral Immune Responses To Control Organ Specific Autoimmunity, Gerard F. Hoyne
Health Sciences Papers and Journal Articles
The immune system must balance the need to maintain a diverse repertoire of lymphocytes to be able to fight infection with the need to maintain tolerance to self proteins. The immune system places strict regulation over the ability of T cells to produce the major T cell growth factor interleukin 2 as this cytokine can influence a variety of immune outcomes. T cells require the delivery of two signals one through the antigen receptor and a second through the costimulatory receptor CD28. The immune system uses a variety of E3 ubiquitin ligases to target signaling proteins that function downstream of …