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Full-Text Articles in Medicine and Health Sciences
A Cell Autonomous Role For The Notch Ligand Delta-Like 3 In Αβ T- Cell Development, Gerard F. Hoyne, Gavin Chapman, Yovina Sontani, Sharon E. Pursglove, Sally L. Dunwoodie
A Cell Autonomous Role For The Notch Ligand Delta-Like 3 In Αβ T- Cell Development, Gerard F. Hoyne, Gavin Chapman, Yovina Sontani, Sharon E. Pursglove, Sally L. Dunwoodie
Health Sciences Papers and Journal Articles
Notch signalling is critical to help direct T-cell lineage commitment in early T-cell progenitors and in the development of αβ T-cells. Epithelial and stromal cell populations in the thymus express the Notch DSL (Delta, Serrate and Lag2) ligands Delta-like 1 (Dll1), Delta-like 4 (Dll4), Jagged 1 and Jagged 2, and induce Notch signalling in thymocytes that express the Notch receptor. At present there is nothing known about the role of the Delta-like 3 (Dll3) ligand in the immune system. Here we describe a novel cell autonomous role for Dll3 in αβ T-cell development. We show that Dll3 cannot activate Notch …