Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Humans (114)
- Female (79)
- Male (65)
- Middle Aged (63)
- Aged (50)
-
- Myocardial Infarction (45)
- Conference presentations (39)
- Animals (37)
- Massachusetts (33)
- Adult (30)
- Monocytes (30)
- Ethanol (24)
- Mice (21)
- Aged, 80 and over (15)
- Lipopolysaccharides (15)
- Incidence (14)
- Time Factors (14)
- Tumor Necrosis Factor-alpha (14)
- Hospital Mortality (13)
- Hospitalization (13)
- Integrins (13)
- Multivariate Analysis (13)
- Signal Transduction (12)
- Cytokines (11)
- Interferon-gamma (11)
- Prognosis (11)
- Risk Factors (11)
- Toll-Like Receptor 2 (11)
- Toll-Like Receptor 4 (11)
- Dendritic Cells (10)
- Publication
-
- Gyongyi Szabo (57)
- Sandra Jones (48)
- Jorge L. Yarzebski (47)
- Arthur M. Mercurio (17)
- Michael A. Rogawski (4)
-
- Peter Williams (4)
- Russ Chess-Williams (4)
- Donald Morrow (3)
- Michael P Lombardo (3)
- Sybil L. Crawford (3)
- Charles Weijer (2)
- Elizabeth J. Luna (2)
- Jeroan J. Allison (2)
- Philip T. Reiss (2)
- A. Bon Gray (1)
- Ahmed Mustafa Dr. (1)
- Alicia Beatty (1)
- Arun Iyer (1)
- Biplab kumar Lenin (1)
- Carroy U "Cuf" Ferguson, Ph.D. (1)
- Dara Wald (1)
- Debashis Ghosh (1)
- Donna M. Zucker (1)
- Dr Hans Wohlmuth (1)
- Helen O'Neill (1)
- Jamaiah Ibrahim (1)
- Janet M. Stavnezer (1)
- Jennifer Kowalski (1)
- Jonathan Allen (1)
- Jonathan Tan (1)
- File Type
Articles 211 - 222 of 222
Full-Text Articles in Medicine and Health Sciences
Supervillin Reorganizes The Actin Cytoskeleton And Increases Invadopodial Efficiency, Jessica Lynn Crowley, Tara C. Smith, Zhiyou Fang, Norio Takizawa, Elizabeth J. Luna
Supervillin Reorganizes The Actin Cytoskeleton And Increases Invadopodial Efficiency, Jessica Lynn Crowley, Tara C. Smith, Zhiyou Fang, Norio Takizawa, Elizabeth J. Luna
Elizabeth J. Luna
Tumor cells use actin-rich protrusions called invadopodia to degrade extracellular matrix (ECM) and invade tissues; related structures, termed podosomes, are sites of dynamic ECM interaction. We show here that supervillin (SV), a peripheral membrane protein that binds F-actin and myosin II, reorganizes the actin cytoskeleton and potentiates invadopodial function. Overexpressed SV induces redistribution of lamellipodial cortactin and lamellipodin/RAPH1/PREL1 away from the cell periphery to internal sites and concomitantly increases the numbers of F-actin punctae. Most punctae are highly dynamic and colocalize with the podosome/invadopodial proteins, cortactin, Tks5, and cdc42. Cortactin binds SV sequences in vitro and contributes to the formation …
Design And Methods For A Randomized Clinical Trial Treating Comorbid Obesity And Major Depressive Disorder, Kristin L. Schneider, Jamie S. Bodenlos, Yunsheng Ma, Barbara C. Olendzki, Jessica Oleski, Philip A. Merriam, Sybil L. Crawford, Ira S. Ockene, Sherry L. Pagoto
Design And Methods For A Randomized Clinical Trial Treating Comorbid Obesity And Major Depressive Disorder, Kristin L. Schneider, Jamie S. Bodenlos, Yunsheng Ma, Barbara C. Olendzki, Jessica Oleski, Philip A. Merriam, Sybil L. Crawford, Ira S. Ockene, Sherry L. Pagoto
Sybil L. Crawford
BACKGROUND: Obesity is often comorbid with depression and individuals with this comorbidity fare worse in behavioral weight loss treatment. Treating depression directly prior to behavioral weight loss treatment might bolster weight loss outcomes in this population, but this has not yet been tested in a randomized clinical trial. METHODS AND DESIGN: This randomized clinical trial will examine whether behavior therapy for depression administered prior to standard weight loss treatment produces greater weight loss than standard weight loss treatment alone. Obese women with major depressive disorder (N = 174) will be recruited from primary care clinics and the community and randomly …
Pharmacology Supplement, Ahmed Mustafa, Ellioott Blumenthal
Pharmacology Supplement, Ahmed Mustafa, Ellioott Blumenthal
Ahmed Mustafa Dr.
No abstract provided.
Haematopoietic Stem Cells In Spleen Have Distinct Differentiative Potential For Antigen Presenting Cells., Jonathan Tan, Helen O'Neill
Haematopoietic Stem Cells In Spleen Have Distinct Differentiative Potential For Antigen Presenting Cells., Jonathan Tan, Helen O'Neill
Helen O'Neill
Dendritic cells (DC) are known to develop from macrophage dendritic progenitors (MDP) in bone marrow (BM), which give rise to conventional (c)DC and monocytes, both dominant antigen presenting cell (APC) subsets in spleen. This laboratory has however defined a distinct dendritic-like cell subset in spleen (L-DC), which can also be derived in long-term cultures of spleen. In line with the restricted in vitro development of only L-DC in these stromal cultures, we questioned whether self-renewing HSC or progenitors exist in spleen with restricted differentiative capacity for only L-DC. Neonatal spleen and BM were compared for their ability to reconstitute mice …
Sport In Canada: A History, Donald Morrow, Kevin Wamsley
Sport In Canada: A History, Donald Morrow, Kevin Wamsley
Donald Morrow
No abstract provided.
Ganaxolone Suppression Of Behavioral And Electrographic Seizures In The Mouse Amygdala Kindling Model, Doodipala S. Reddy, Michael A. Rogawski
Ganaxolone Suppression Of Behavioral And Electrographic Seizures In The Mouse Amygdala Kindling Model, Doodipala S. Reddy, Michael A. Rogawski
Michael A. Rogawski
Ganaxolone (3alpha-hydroxy-3alpha-methyl-5alpha-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator of GABA-A receptors, may represent a new treatment approach for epilepsy. Here we demonstrate that pretreatment with ganaxolone (1.25—20 mg/kg, s.c.) causes a dose-dependent suppression of behavioral and electrographic seizures in fully amygdala-kindled female mice, with nearly complete seizure protection at the highest dose tested. The ED50 for suppression of behavioral seizures was 6.6 mg/kg. The seizure suppression produced by ganaxolone was comparable to that of clonazepam (ED50, 0.1 mg/kg, s.c.). To the extent that amygdala kindling represents a model of mesial temporal lobe epilepsy, …
Neurosteroids On The Epilepsy Chessboard — Keeping Seizures In Check, Michael A. Rogawski
Neurosteroids On The Epilepsy Chessboard — Keeping Seizures In Check, Michael A. Rogawski
Michael A. Rogawski
No abstract provided.
Treatment Of Early And Late Kainic-Acid Induced Status Epilepticus With The Non-Competitive Ampa Receptor Antagonist Gyki 52466, Brita Fritsch, Jeffrey J. Stott, J. Joelle Donofrio, Michael A. Rogawski
Treatment Of Early And Late Kainic-Acid Induced Status Epilepticus With The Non-Competitive Ampa Receptor Antagonist Gyki 52466, Brita Fritsch, Jeffrey J. Stott, J. Joelle Donofrio, Michael A. Rogawski
Michael A. Rogawski
Purpose: Benzodiazepines such as diazepam may fail to effectively treat status epilepticus because benzodiazepine-sensitive GABA-A receptors are internalized progressively with continued seizure activity. Ionotropic glutamate receptors, including AMPA receptors, are externalized, so that AMPA receptor antagonists, which are broad-spectrum anticonvulsants, could be more effective treatments for satus epilepticus. We assessed the ability of the non-competitive AMPA receptor antagonist GYKI 52466 to protect against kainic acid-induced status epilepticus in mice. Methods: Groups of animals treated with kainic acid received GYKI 52466 (50 mg/kg followed in 15 min by 50 mg/kg) or diazepam (25 mg/kg followed in 20 min by 12.5 mg/kg) …
Anticonvulsant And Proconvulsant Actions Of 2-Deoxy-D-Glucose, Maciej Gasior, Jessica Yankura, Adam L. Hartman, Amy French, Michael A. Rogawski
Anticonvulsant And Proconvulsant Actions Of 2-Deoxy-D-Glucose, Maciej Gasior, Jessica Yankura, Adam L. Hartman, Amy French, Michael A. Rogawski
Michael A. Rogawski
Purpose: 2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes, has anticonvulsant actions. Recognizing that severe glucose deprivation can induce seizures, we sought to determine whether acute treatment with 2-DG can promote seizure susceptibility by assessing its effects on seizure threshold. For comparison, we studied 3-methyl-glucose (3-MG), which like 2-DG accumulates in cells and reduces glucose uptake, but does not inhibit glycolysis. Methods: Mice were treated with 2-DG or 3-MG and the seizure threshold determined in the 6-Hz test, the mouse electroshock seizure threshold (MEST) test, and the intravenous pentylenetetrazol (i.v. …
Prevalence Of Scabies And Head Lice Among Children In A Welfare Home In Pulau Pinang, Malaysia, Jamaiah Ibrahim
Prevalence Of Scabies And Head Lice Among Children In A Welfare Home In Pulau Pinang, Malaysia, Jamaiah Ibrahim
Jamaiah Ibrahim
This is a survey of 120 children for scabies and head lice infestations in a welfare home in Pulau Pinang. Children from this welfare home (Rumah Kanak-Kanak Taman Bakti, Kepala Batas, Pulau Pinang) were randomly selected. Majority of them were Malays (72.5%) and the rest were Indians. The infestation rates were highest in the 10-12 years age group with 46% and 70% for scabies and head lice respectively. Head lice was more commonly seen in girls (65%) than boys (29%). Scabies was more commonly seen in boys (50%) than girls (16%). Overall prevalence rate for scabies was 31% and for …
Semiparametric Analysis Of Recurrent Events: Artificial Censoring, Truncation, Pairwise Estimation And Inference, Debashis Ghosh
Semiparametric Analysis Of Recurrent Events: Artificial Censoring, Truncation, Pairwise Estimation And Inference, Debashis Ghosh
Debashis Ghosh
The analysis of recurrent failure time data from longitudinal studies can be complicated by the presence of dependent censoring. There has been a substantive literature that has developed based on an artificial censoring device. We explore in this article the connection between this class of methods with truncated data structures. In addition, a new procedure is developed for estimation and inference in a joint model for recurrent events and dependent censoring. Estimation proceeds using a mixed U-statistic based estimating function approach. New resampling-based methods for variance estimation and model checking are also described. The methods are illustrated by application to …
An Intervention To Prevent Symptoms Associated With Hepatitis C: A Pilot Study, Donna M. Zucker
An Intervention To Prevent Symptoms Associated With Hepatitis C: A Pilot Study, Donna M. Zucker
Donna M. Zucker
The objectives of this study were to (a) pilot test instruments measuring fatigue and quality of life (QOL); (b) pilot test an exercise intervention; and (c) estimate the effect size of this intervention relative to completion of combination therapy, fatigue, QOL, and walking distance in 20 patients with chronic hepatitis C about to begin interferon alpha and ribavirin treatment. Alpha reliabilities for both the Schwartz Cancer Fatigue Scale and Hepatitis Quality of Life Questionnaire were moderately high. Power analyses of all outcome measures indicated a small effect size and sample size estimate of 30–40 per group to achieve power of …