Medicine and Health Sciences Commons^™

Candida Albicans Farnesol Synthesis And Secretion, Daniel J. Gutzmann

School of Biological Sciences: Dissertations, Theses, and Student Research

Candida albicans is a polymorphic fungus and opportunistic commensal found primarily in the gastrointestinal and skin of healthy individuals. Several barriers prevent C. albicans from causing disease including a healthy immune system and microbiome. When these barriers become comprised, C. albicans can transition to a pathogen and disseminate through the intestinal mucosa leading to life-threatening bloodstream and invasive infections with mortality rates of up to 64%. Morphogenic plasticity is key to this transition and impacts virulence, adaptation to different host environments, and evasion of host immune responses. One regulator of morphogenesis is farnesol. Farnesol is a secondary metabolite …

Concepts In Animal Parasitology, Scott L. Gardner, Sue Ann Gardner

Zea E-Books Collection

This is a textbook covering concepts in animal parasitology. It is meant to be used by students, teachers, professors, researchers, and members of the public who are interested in learning about animal parasite biology, systematics, taxonomy, zoogeography, and ecology. The primary intended audience is upper-level undergraduate or graduate university students who have knowledge of basic biology and, particularly, basic animal biology. (863 pages, illustrated)

One of the most fascinating things that a person can experience in the complex realm of biology is the discovery of an animal living inside another animal. If this discovery takes place at an early enough …

Concepts In Animal Parasitology: Master Bibliography, Sue Ann Gardner

Concepts in Animal Parasitology Textbook

Master bibliography for the open educational resource/open access textbook Concepts in Animal Parasitology, Scott L. Gardner and Sue Ann Gardner, editors, published by Zea Books, Lincoln, Nebraska, United States, 2024. This includes the references from literature cited and suggested supplemental reading.

Identification Of Novel Small Molecule Inhibitors Of Twin Arginine Translocation (Tat) Pathway And Their Effect On The Control Of Campylobacter Jejuni In Chickens, Loïc Deblais, Mary Drozd, Anand Kumar, Janet Antwi, James Fuchs, Rahul Khupse, Yosra A. Helmy, Gireesh Rajashekara

School of Veterinary and Biomedical Sciences: Faculty Publications

Introduction: Control of Campylobacter from farm to fork is challenging due to the frequent emergence of antimicrobial-resistant isolates. Furthermore, poultry production systems are known reservoirs of Campylobacter. The twinarginine translocation (Tat) pathway is a crucial bacterial secretion system that allows Campylobacter to colonize the host intestinal tract by using formate as the main source of energy. However, Tat pathway is also a major contributing factor for resistance to copper sulfate (CuSO₄).

Methods: Since mammals and chickens do not have proteins or receptors that are homologous to bacterial Tat proteins, identification of small molecule (SM) inhibitors …

Isothiocyanates Potentiate Tazemetostat-Induced Apoptosis By Modulating The Expression Of Apoptotic Genes, Members Of Polycomb Repressive Complex 2, And Levels Of Tri-Methylating Lysine 27 At Histone 3 In Human Malignant Melanoma Cells, Ioannis Anestopoulos, Ioannis Paraskevaidis, Sotiris Kyriakou, Lambrini E. Giova, Dimitrios T. Trafalis, Sotiris Botaitis, Rodrigo Franco, Aglaia Pappa, Mihalis L. Panayiotidis

School of Veterinary and Biomedical Sciences: Faculty Publications

In this study, we utilized an in vitro model consisting of human malignant melanoma as well as non-tumorigenic immortalized keratinocyte cells with the aim of characterizing the therapeutic effectiveness of the clinical epigenetic drug Tazemetostat alone or in combination with various isothiocyanates. In doing so, we assessed markers of cell viability, apoptotic induction, and expression levels of key proteins capable of mediating the therapeutic response. Our data indicated, for the first time, that Tazemetostat caused a significant decrease in viability levels of malignant melanoma cells in a dose- and time-dependent manner via the induction of apoptosis, while non-malignant keratinocytes were …

Gene Editing Of Pigs To Control Influenza A Virus Infections, Taeyong Kwon, Bianca L. Artiaga, Chester D. Mcdowell, Kristin M. Whitworth, Kevin D. Wells, Randall S. Prather, Gustavo Delhon, Mark Cigan, Stephen N. White, Jamie Retallick, Natasha N. Gaudreault, Igor Morozov, Juergen A. Richt

School of Veterinary and Biomedical Sciences: Faculty Publications

Proteolytic activation of the hemagglutinin (HA) glycoprotein by host cellular proteases is pivotal for influenza A virus (IAV) infectivity. Highly pathogenic avian influenza viruses possess the multibasic cleavage site of the HA which is cleaved by ubiquitous proteases, such as furin; in contrast, the monobasic HA motif is recognized and activated by trypsin-like proteases, such as the transmembrane serine protease 2 (TMPRSS2). Here, we aimed to determine the effects of TMPRSS2 on the replication of pandemic H1N1 and H3N2 subtype IAVs in the natural host, the pig. The use of the CRISPR/Cas 9 system led to the establishment of homozygous …

Naturally Derived Phenethyl Isothiocyanate Modulates Induction Of Oxidative Stress Via Its N-Acetylated Cysteine Conjugated Form In Malignant Melanoma, Sotiris Kyriakou, Nikoletta Demosthenous, Tom Amery, Kyle J. Stewart, Paul G. Winyard, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis

School of Veterinary and Biomedical Sciences: Faculty Publications

Phenethyl isothiocyanate (PEITC) is a secondary metabolic product yielded upon the hydrolysis of gluconasturtiin and it is highly accumulated in the flowers of watercress. The aim of the current study was to assess the role of a naturally derived PEITC-enriched extract in the induction of oxidative stress and to evaluate its anti-melanoma potency through the regulation of its metabolism with the concurrent production of the N-acetyl cysteine conjugated by-product. For this purpose, an in vitro melanoma model was utilized consisting of human primary (A375) cells as well as metastatic (COLO-679) malignant melanoma cells together with non-tumorigenic immortalized keratinocytes (HaCaT). …

Concepts In Animal Parasitology, Chapter 02: Phylogenetic Systematics In Parasitology, Anindo Choudhury

Concepts in Animal Parasitology Textbook

Chapter 2 in Concepts in Animal Parasitology on phylogenetic systematics in parasitology by Anindo Choudhury. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap002

Concepts In Animal Parasitology, Chapter 05: Life Cycles, Matthew G. Bolek, Kyle D. Gustafson, Gabriel J. Langford

Concepts in Animal Parasitology Textbook

Chapter 5 in Concepts in Animal Parasitology on life cycles by Matthew G. Bolek, Kyle D. Gustafson, and Gabriel J. Langford. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap005

Concepts In Animal Parasitology, Chapter 06: Behavioral Parasitology, Megan Wise De Valdez

Concepts in Animal Parasitology Textbook

Chapter 6 in Concepts in Animal Parasitology on behavioral parasitology by Megan Wise de Valdez. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap006

Concepts In Animal Parasitology, Chapter 08: Distributional Ecology Of Parasites, A. Townsend Peterson

Concepts in Animal Parasitology Textbook

Chapter 8 in Concepts in Animal Parasitology on distributional ecology of parasites by A. Townsend Peterson. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap008

Concepts In Animal Parasitology, Chapter 10: Haemosporida (Order): The “Malaria Parasites”, Susan L. Perkins, Spencer C. Galen

Concepts in Animal Parasitology Textbook

Chapter 10 in Concepts in Animal Parasitology on the order Haemosporida, the “malaria parasites,” by Susan L. Perkins and Spencer C. Galen. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap010

Concepts In Animal Parasitology, Chapter 24: Cathetocephalidea Schmidt And Beveridge, 1990 (Order), Luis García-Prieto, Omar Lagunas-Calvo, Brenda Atziri García-García, Berenice Adán-Torres

Concepts in Animal Parasitology Textbook

Chapter 24 in Concepts in Animal Parasitology on the order Cathetocephalidea Schmidt and Beveridge, 1990 by Luis García-Prieto, Omar Lagunas-Calvo, Brenda Atziri García-García, and Berenice Adán-Torres. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap024

Concepts In Animal Parasitology, Chapter 32: Gyrocotylidea (Order): The Most Primitive Group Of Tapeworms, Willi E. R. Xylander, Klaus Rohde

Concepts in Animal Parasitology Textbook

Chapter 32 in Concepts in Animal Parasitology on the most primitive group of tapeworms, the order Gyrocotylidea by Willi E. R. Xylander and Klaus Rohde. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap032

Concepts In Animal Parasitology, Chapter 37: Bivesiculata Olson Et Al., 2003 (Suborder): Small, Rare, But Important, Thomas H. Cribb, Scott C. Cutmore

Concepts in Animal Parasitology Textbook

Chapter 37 in Concepts in Animal Parasitology on the small, rare, but important suborder Bivesiculata Olson et al., 2003 by Thomas H. Cribb and Scott C. Cutmore. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap037

Concepts In Animal Parasitology, Chapter 42: Opisthorchis (Genus), Sue Ann Gardner

Concepts in Animal Parasitology Textbook

Chapter 42 in Concepts in Animal Parasitology on the trematode genus Opisthorchis compiled by Sue Ann Gardner from information from the United States Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap042

Concepts In Animal Parasitology, Chapter 44: Haematoloechidae Odening, 1964 (Family), Virginia León-Règagnon

Concepts in Animal Parasitology Textbook

Chapter 44 in Concepts in Animal Parasitology on the family Haematoloechidae Odening, 1964 by Virginia León-Règagnon. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap044

Concepts In Animal Parasitology, Chapter 45: Lecithodendriidae Lühe, 1901 (Family), Jeffrey M. Lotz

Concepts in Animal Parasitology Textbook

Chapter 45 in Concepts in Animal Parasitology on the family Lecithodendriidae Lühe, 1901 by Jeffrey M. Lotz. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap045

Concepts In Animal Parasitology, Chapter 48: Introduction To Endoparasitic Nematodes (Phylum Nemata), Scott L. Gardner

Concepts in Animal Parasitology Textbook

Chapter 48 in Concepts in Animal Parasitology, an introduction to endoparasitic nematodes (phylum Nemata) by Scott L. Gardner. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap048

Concepts In Animal Parasitology, Chapter 53: Spirurida (Order), Valentin Radev

Concepts in Animal Parasitology Textbook

Chapter 53 in Concepts in Animal Parasitology on the order Spirurida by Valentin Radev. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap053

Concepts In Animal Parasitology, Chapter 57: Nematomorpha (Phylum): Horsehair Worms, Matthew G. Bolek, Ben Hanelt

Concepts in Animal Parasitology Textbook

Chapter 57 in Concepts in Animal Parasitology on the horsehair worms, phylum Nematomorpha, by Matthew G. Bolek and Ben Hanelt. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap057

Concepts In Animal Parasitology, Chapter 59: Pentastomida: Endoparasitic Arthopods, Chris T. Mcallister

Concepts in Animal Parasitology Textbook

Chapter 59 in Concepts in Animal Parasitology on the Pentastomida, endoparasitic athropods, by Chris T. McAllister. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap059

Concepts In Animal Parasitology, Chapter 66: Acari (Order): Ticks, Darci Moraes Barros-Battesti, Valeria Castilho Onofrio, Filipe Dantas-Torres

Concepts in Animal Parasitology Textbook

Chapter 66 in Concepts in Animal Parasitology on ticks (order Acari) by Darci Moraes Barros-Battesti, Valeria Castilho Onofrio, and Filipe Dantas-Torres. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap066

Concepts In Animal Parasitology, Part 2: Protozoa, Myxozoa, Mesozoa, Donald W. Duszynski, Susan L. Perkins, Spencer C. Galen, Ana Maria Jansen, Samanta C. Chagas Xavier, André Luiz Rodrigues Roque, Mary Ann Mcdowell, Jennifer Robichaud, Terrence L. Miller, Sarah R. Catalano

Concepts in Animal Parasitology Textbook

Part II: Protozoa, Myxozoa, Mesozoa, chapters 9-14, pages 105-141, in Concepts in Animal Parasitology. 2024. Scott L. Gardner and Sue Ann Gardner, editors. Zea Books, Lincoln, Nebraska, United States; part II doi: 10.32873/unl.dc.ciap072

Protozoa: Apicomplexa

Chapter 9: The Coccidia Proper: Important Apicomplexa Other than Haemoprotozoa by Donald W. Duszynski, pages 105-139

Chapter 10: Haemosporida (Order): The “Malaria Parasites” by Susan L. Perkins and Spencer C. Galen, pages 140-155

Protozoa: Trypanosomatidae

Chapter 11: Trypanosoma (Genus) by Ana Maria Jansen, Samanta C. Chagas Xavier, and André Luiz Rodrigues Roque, pages 156-181

Chapter 12: Leishmania (Genus) and Leishmaniasis by Mary Ann McDowell and …

Concepts In Animal Parasitology, Part 4: Nemata, Nematomorpha, Acanthocephala, Pentastomida, Scott L. Gardner, María Del Rosario Robles, Rocío Callejón Fernández, John J. Janovy Jr., Steven A. Nadler, F. Agustín Jiménez-Ruiz, Haylee J. Weaver, Valentin Radev, Anindo Choudhury, Juliana Notarnicola, Matthew G. Bolek, Ben Hanelt, Scott Monks, Chris T. Mcallister

Concepts in Animal Parasitology Textbook

Part IV: Nemata, Nematomorpha, Acanthocephala, Pentastomida, chapters 48-59, pages 532-, in Concepts in Animal Parasitology. 2024. Scott L. Gardner and Sue Ann Gardner, editors. Zea Books, Lincoln, Nebraska, United States; part IV doi: 10.32873/unl.dc.ciap074

Nemata: Endoparasitic Nematodes

Chapter 48: Introduction to Endoparasitic Nematodes (Phylum Nemata) by Scott L. Gardner, pages 533-544

Chapter 49: Trichuroidea and Trichinelloidea (Superfamilies) by María del Rosario Robles and Rocío Callejón Fernández, pages 545-565

Chapter 50: Ascaridoidea (Superfamily): Large Intestinal Nematodes by Larry S. Roberts, John J. Janovy, Jr., Steven Nadler, and Scott L. Gardner, pages 566-581

Chapter 51: Heterakoidea (Superfamily): Cosmopolitan Gut-Dwelling Parasites of Tetrapods …

Concepts In Animal Parasitology: Front And Back Matter, Sue Ann Gardner

Concepts in Animal Parasitology Textbook

Preface and list of contributors for Concepts in Animal Parasitology. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap070

Concepts In Animal Parasitology, Chapter 09: The Coccidia Proper: Important Apicomplexa Other Than Haemoprotozoa, Donald W. Duszynski

Concepts in Animal Parasitology Textbook

Chapter 9 in Concepts in Animal Parasitology on the Coccidia Ppoper, important Apicomplexa other than Haemoprotozoa by Donald W. Duszynski. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap009

Concepts In Animal Parasitology, Chapter 20: Proteocephalidae La Rue, 1911 (Family), Tomáš Scholz, Roman L. Kuchta

Concepts in Animal Parasitology Textbook

Chapter 20 in Concepts in Animal Parasitology on the family Proteocephalidae La Rue, 1911 by Tomáš Scholz and Roman Kuchta. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap020

Concepts In Animal Parasitology, Chapter 21: Bothriocephalidea Kuchta Et Al., 2008 (Order), Jorge Falcón-Ordaz, Luis García-Prieto

Concepts in Animal Parasitology Textbook

Chapter 21 in Concepts in Animal Parasitology on the order Bothriocephalidea Kuchta et al., 2008 by Jorge Falcón-Ordaz and Luis García-Prieto. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap021

Concepts In Animal Parasitology, Chapter 25: Diphyllidea Van Beneden In Carus, 1863 (Order), Luis García-Prieto, Brenda Atziri García-García, Omar Lagunas-Calvo, Berenice Adán-Torres

Concepts in Animal Parasitology Textbook

Chapter 25 in Concepts in Animal Parasitology on the order Diphyllidea van Beneden in Carus, 1863 by Luis García-Prieto, Brenda Atziri García-García, Omar Lagunas-Calvo, and Berenice Adán-Torres. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap025