Medicine and Health Sciences Commons^™

Stress And Eating Behaviors Pre- And Post Covid-19 Pandemic Declaration In A Sample Of College-Aged Adults, Megan Bratetic, Michelle Nguyen, Makenna Peterson, Anthony Acevedo, Zachary Zeigler

International Journal of Exercise Science: Conference Proceedings

Purpose: This study compared stress and eating behaviors pre- and post-COVID-19 pandemic in college students. METHODS: This was a non-experimental comparative study. Participants were invited to the laboratory for a single visit to measure eating behaviors and stress indicators. Four instruments were used in this study: The Weight and Lifestyle Inventory questionnaire, the Mindfulness Eating Questionnaire, the Three-Factor Eating Questionnaire, and the Perceived Stress Scale. Independent t-test and a two-way ANOVA were used to compare participants who were tested before the COVID-19 pandemic declaration and after. RESULTS: N=151 (n=81 male, n=70 female) participants completed pre-covid testing, and a separate group, …

Bicycle Handlebar Width Does Not Affect Spirometry, Ventilation, Or Gas Exchange, Matthew J. Fahey, Daniel T. Cannon

International Journal of Exercise Science: Conference Proceedings

Bicycle fit may affect comfort, aerodynamics, efficiency, ventilation, and power generation. Handlebars determine how the rider interacts with the bicycle. A wide range of handlebar widths are commercially available, but it is unclear if the resultant position affects lung function, ventilation, gas exchange, or efficiency. PURPOSE We aimed to measure the effects of handlebar widths on ventilation, gas exchange, spirometry, and comfort during moderate constant power exercise. METHODS Twenty-four recreationally active adults completed the study (32 ± 5 yrs., 175 ± 9 cm, 74 ± 12 kg, 8 women, 16 men). Participants completed three moderate constant power bouts of exercise …

Validity And Reliability Of The Polar Oh1 Biceps-Band Heart Rate Monitor During Pickleball, Jamaal K. Bovell, Dustin W. Davis, Bryson Carrier, Setareh Zarei, Tashari A. Carballo, Matahn Blank, Thea Sweder, Samantha Cruz, Elias M. Malek, James W. Navalta

International Journal of Exercise Science: Conference Proceedings

Pickleball is making a name for itself as one of the fastest growing sports in the United States. According to the Association of Pickleball Professionals (APP), 14% of Americans 18 years and over (~36.5 million people) played pickleball at least once in 12 months. With almost half of the total players planning to play more often in the upcoming months, pickleball is certain to continue its ascension. It is unclear if paying intensity can be gauged accurately and reliably with heart rate (HR) measurements from biceps-band monitors. PURPOSE: This study aimed to determine the validity and reliability of the Polar …

Assessing The Reliability Of Stryd 27 For Variable Speed Running, Kathryn A. Lavin, Dustin W. Davis, Matahn Blank, Tashari A. Carballo, Elias M. Malek, Thea Sweder, Eric Lambert, Nicole Argueta, Marcus M. Lawrence, Jeffrey Cowley, James W. Navalta

International Journal of Exercise Science: Conference Proceedings

Wearable technology is beneficial when it comes to tracking and optimizing performance. The Stryd 27 is a wearable footpod marketed as being more responsive in measuring power during running than the previous version (Stryd 25). However, the reliability of this newer device to return consistent values has not been determined. PURPOSE: This study aimed to observe whether Stryd 27 gives reliable metrics during variable speed running. METHODS: Sixteen participants (N = 16; 50% female; height = 174.1 ± 8.1 cm; mass = 73.0 ± 12.4 kg) were recruited, each equipped with two Stryd 27 footpods (updated to the same …

The Impact Of Acute Sauna On Young And Middle-Aged Populations, Ari Young, Olivia Leach, Jayson Gifford

International Journal of Exercise Science: Conference Proceedings

Sauna exposure is a common form of whole-body heating therapy. Previous studies done on the older population, suggest a positive correlation between time spent in sauna and cardiovascular health. Heat stress induces changes in the vascular response, but the effects on middle-aged and young populations are unknown. PURPOSE: To determine effects of whole-body heating on vascular resistance and blood pressure in young and middle-aged populations. METHODS: We recruited 18 individuals (10 young; 4 female, male, age= ~24.9yrs and 8 middle-aged; 4 female, 4 male, age= ~55.75yrs). Two T-type thermocouples were placed in the esophagus and vastus lateralis to …

The Effects Of Initiating A 24-Hour Fast With A Low Versus A High Carbohydrate Shake On Pancreatic Hormones In The Elderly: A Randomized Crossover Study, Mckay Knowlton, Landon Deru, Bruce W. Bailey

International Journal of Exercise Science: Conference Proceedings

Begin PURPOSE: The aim of this study is to understand how the macronutrient composition of the fast-initiating meal influences glucose regulating hormones during, and 24-hours after a 24-hour fast in older, sedentary, and abdominally obese adults. Understanding these outcomes will inform fasting protocols such as time restricted eating and alternate day fasting, which offer potential long-term health benefits. METHODS: We had 16 participants (7 male, 9 female). Each participant completed two 24-hour fasts (water only). In random order, one fast began with a high carb/low fat (HC/LF) shake and the other with a low carbohydrate/high fat shake (LC/HF) (equal calorie, …

Acute Heat Stress On Blood Composition & Body Fluid In Young And Middle-Aged Individuals, Kaitlyn Strong, Olivia Leach, Jayson Gifford

International Journal of Exercise Science: Conference Proceedings

Sauna therapy has been shown to have benefits to cardiovascular health. Changes in hematocrit, hemoglobin, and plasma volume in response to sauna heating are not well defined in the middle-aged population. This population is of significant interest because of an increased rate of decline in cardiovascular health starting at middle age. PURPOSE: The purpose of this study was to examine the effect of acute sauna exposure on blood composition, specifically the change in plasma volume in young and middle-aged adults. METHODS: 10 young (24.9 ± 4.2 years, 6 male and 4 female) and 8 middle-aged adults (55.6 ± 3.9 …

Co-Ingestion Of Dietary Nitrate And Ascorbic Acid On Nitric Oxide Biomarkers And The Oral Microbiome In Sedentary Hispanic Women, Jeffrey Li, Keonabelle K. Paniagua, Joanna P. Powell, Sean T. Karl, Isabella G. Lincoln, Noelle G. Seekamp-Hicks, Leah T. Stiemsma, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

Nitric oxide bioavailability increases following nitrate supplementation wherein oral microbiota facilitate the metabolism and absorption of nitrate. However, few studies have examined if co-ingestion of nitrate with antioxidants can further elevate nitric oxide bioavailability. Moreover, our understanding on how the oral microbiome responds to nitrate supplementation is limited, especially in women. PURPOSE: To examine the effects of ingesting dietary nitrate and ascorbic acid independently and concurrently on markers of nitric oxide bioavailability and oral microbiota species. METHODS: Twelve sedentary women of Hispanic descent (mean ± SD: age 20 ± 1 years; body mass 74 ± 15 kg; height …

Acute Beetroot Juice Ingestion Increases Nitric Oxide Bioavailability Without Changing Oral Microbial Composition In Healthy Young Women, Alexandra C. Zink, Courtney Merrill, Jeffrey Li, Luka K. Sharabidze, Leah T. Stiemsma, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

Dietary nitrate supplementation can elicit beneficial health and exercise performance effects. Oral microbiota are critical for the metabolism of exogenously consumed nitrate; however, limited data are available on the influence of dietary nitrate ingestion on bacterial taxa and in women. PURPOSE: To investigate if acute dietary nitrate ingestion alters the oral microbiota in young healthy women compared to a nitrate-depleted placebo. METHODS: In a randomized double-blinded crossover design, fifteen recreationally active women (mean ± SD: age 20 ± 1 years; body mass 63 ± 10 kg; height 1.68 ± 0.1 m) participated in two conditions to ingest nitrate-rich …

The Effect Of Menstruation Duration On The Achilles Tendon Cross-Sectional Area In Female Ballet Dancers, Kaitong Li, Wayne Johnson, Steven Allen, Shayla Bott, Chris Dillon, Joshua Sponbeck, Camille Nguyen Jones, Annie Smedley

International Journal of Exercise Science: Conference Proceedings

Females are more likely to suffer Achilles tendon injury that consequently leads to more complications including pain or tendon rupture, and experiencing fewer benefits from therapeutic interventions. There is a lack of knowledge on how estrogen, which may limit collagen synthesis, can affect tendon health and growth. PURPOSE: The objective of this study is to examine the relationship between menstruation duration and cross-sectional area (CSA) of the Achilles tendon over a 5-month period of intensive dance training. We hypothesize the female dancers who reported a menstruation duration of 1-3 days will have the smallest average tendon CSA in comparison …

Does Hand Use Affect Metabolic Measures During Pickleball, Tashari A. Carballo, Matahn Blank, Bryson Carrier, Samantha Cruz, Jae Bovell, Dustin W. Davis, Thea Sweder, Elias M. Malek, Setareh Zarei, James W. Navalta

International Journal of Exercise Science: Conference Proceedings

Pickleball is one of the fastest up and coming sports in the United States today. This low impact sport has the combined elements of Ping-Pong, tennis, and badminton. Pickleball can be played with the dominant hand (DH) or non-dominant (NDH). Though many people enjoy the sport, it is under-researched. The metabolic demands of pickleball are not clear, nor is whether the demands differ by the hand used. PURPOSE: The aim of this study was to determine the differences in metabolic measures while playing pickleball with the DH and NDH. METHODS: Eleven people were recruited via convenience sampling and participated (2 …

Stryd 25 Vs. Stryd 27: Comparing Running Metrics Between A Predecessor And “The Next Gen Stryd”, Dustin W. Davis, Matahn A. Blank, Tashari A. Carballo, Elias M. Malek, Kathryn A. Lavin, Thea S. Sweder, Eric A. Lambert, Nicole Argueta, Marcus M. Lawrence, Jeffrey Cowley, James W. Navalta

International Journal of Exercise Science: Conference Proceedings

Wearable technology has claimed the top spot in the Worldwide Survey of Fitness Trends in all but two years since 2016. A popular wearable among runners is the Stryd power meter. The company markets its latest model, the Stryd 27, as 5x more responsive in measuring running power. Yet, it is unclear whether the new model performs differently than its predecessor. PURPOSE: This study aimed to compare running metrics of the Stryd 25 and Stryd 27 in self-paced and interval runs. METHODS: Participants consented (N = 16; 50% female; height = 174.1 ± 8.1 centimeters [cm]; mass …

Greater Motor Evoked Torque In Aclr Patients During Force Reproduction Task Compared To Health Controls, Anisha A. Patel, Christine E. Phelps, Haley Huntington, Lana J. Kayali, Caitlyn E. Olshausen, Anika Khurana, Tina Boluordi, Yong Woo An

International Journal of Exercise Science: Conference Proceedings

Persistent quadriceps dysfunction following anterior cruciate ligament reconstruction (ACLR) may lead to further pathological complication. Quadriceps weakness has been linked to corticospinal excitability. However, it remains unclear how this altered corticospinal excitability contributes to ACLR patients during knee strength tasks when compared to healthy controls. PURPOSE: The purpose of this study was to examine force reproduction strategies during isometric knee extension between ACLR patients and healthy controls. METHODS: Five ACLR (20.40±1.67yrs, 72.12±12.87kg, 171.07±7.40cm) participants and five matched healthy controls (21.00±1.73yrs, 65.77±13.61kg, 166.62±11.99cm) performed an isometric force reproduction task. They were instructed to maintain 10% of maximal voluntary isometric contraction (MVIC) …

Social Jetlag Inhibits Exercise-Induced Adaptations In The Heart And Alters Markers Of Mitochondrial Dynamics, Graham R. Mcginnis, Michael B. Dial, Elias M. Malek, Greco Neblina, Austin Cooper, Nikoleta Vasileva, Tanner Erwin

International Journal of Exercise Science: Conference Proceedings

Social jetlag (SJL), or the shifting of behavior and sleep times between weekdays and weekends, is a pervasive form of circadian rhythm disruption that affects nearly 70% of the population to some extent. The magnitude of SJL can be determined by the difference in the mid-sleep phase between weekends and weekdays. Higher levels of SJL have been associated with lower levels of cardiorespiratory fitness, and increased incidence of cardiometabolic disease, which may be due, in part, to mitochondrial dysfunction. However, no studies to date have evaluated the effects of long term SJL on cardiac mitochondrial dynamics. PURPOSE: To determine …

Effects Of Partial Hot Water Immersion On Postprandial Blood Glucose And Heart Rate Variability, Jeff Moore, Michael Buono

International Journal of Exercise Science: Conference Proceedings

The acute effects of heat therapy on glycemic markers oppose those of the chronic effects. While the postprandial glucose response is exaggerated during whole body heat exposure, chronic heat exposure lowers HbA1c. Additionally, the acute effects of heat therapy differ depending on the amount of body exposed to heat. Heating a single hand does not increase fasting glucose and lowers postprandial glucose. The opposing effects of partial and whole body heat exposure could be mediated in part from increased sympathetic nervous system (SNS) activity following heat stress. While heating the body increases muscular blood flow and glucose uptake, SNS activation …

Evaluation Of Caloric Expenditure Metrics Of Garmin Instinct Wearable Technology Devices During Pickleball, Matahn A. Blank, Dustin W. Davis, Bryson Carrier, Tashari A. Carballo, Jae K. Bovell, Thea Sweder, Samantha Cruz, Zhihao Yu, Setareh Zarei, James W. Navalta

International Journal of Exercise Science: Conference Proceedings

While tennis and badminton may present a moderate learning curve for beginners, pickleball, a similar racquet sport that has become increasingly popular in recent years, offers a notably simpler play-style that can be more easily adapted for new players. This sport has emerged during a time when wearable technology devices, such as the Garmin Instinct, have become commonly used to estimate physiological measures among individuals engaging in physical activity. Yet, there is little research that examines the validity and reliability of this technology during pickleball. PURPOSE: The purpose of this study was to assess the reliability and validity of …

Validation Of Vertical Force Measures During Hop Tasks Using Pressure Insoles, Andrew Cho, Erin Cagle, Sylwia Lipior, Susan Sigward

International Journal of Exercise Science: Conference Proceedings

Assessment of vertical ground reaction forces (vGRF) during jumping and landing tasks is commonly used as a tool to quantify limb loading following injury. While embedded force plates are the current gold standard, cost and poor ecological validity limit their feasibility for assessment of loading during sport agility tasks. Wearable pressure insoles can measure plantar pressure wirelessly and may provide an alternative for on-field assessments. Previous studies have assessed the validity of insoles with varying results. Few studies have considered tasks that require both vertical and horizontal forces similar to those required for agility tasks. This may have important implications …

Interprofessional Education Among Health Care Professionals In The Care Of Autistic Children During The Last Two Decades (2001 To 2020): A Systematic Review Protocol, Sunitha Solomon Nagelli Ms., Sushmitha Karkada Dr., Ravishankar N Dr.

Manipal Journal of Nursing and Health Sciences

Introduction: Autism Spectrum Disorder requires management from multiple health professionals at various settings during the course of treatment. Interprofessional collaborative practice has been identified as one of the promising methods of care for an all-round healthcare management.

Objective: Collate empirical evidence on interprofessional education among healthcare professionals in providing care for children with autism

Method: Search will be conducted from five databases against the selected criteria. Review will be restricted to studies in English between 2001 to 2020 only. Two independent reviewers will scrutinize the abstract and title, and every study document retrieved will be investigated as …

The Lived Experience Of Second-Degree Nursing Students’ Anxiety Before And During Their Initial Clinical Rotation, Shelly Wheatley

Graduate Theses, Dissertations, and Capstones

Anxiety in nursing students can impact learning. Literature has shown that nursing students, especially those in second-degree nursing programs, report higher stress levels compared to other undergraduate students (Penprase & Koczara, 2009). Nursing clinicals can be jarring for students and present many stressors that can impeded learning and cause poor clinical performance. Much research has been done about traditional undergraduate students’ feelings of anxiety. There is a noted gap in research of second-degree, accelerated nursing students and their feelings about their initial clinical placement. Comparisons have often been made between traditional and nontraditional students, but the lived experiences of second-degree …

Youth Shelter Bed Bugs & Lice Education, Madeline Mary Rettenmier, Elvina S. Kuzubov, Quoc H. Phan, Megan Myra Joseph, Allie Mechtel

Nursing Leadership in Community Engagement Projects

Youth Shelter Bed Bugs & Lice Education
Allie Mechtel, Maddy Rettenmier, Elvina Kuzubov, Megan Joseph, Kevin Phan
School of Health Sciences, Seattle Pacific University
NUR 4153: Nursing Leadership in Community Engagement
Leah Ngoche DNP, MPH, ARNP-BC
8 November 2023

Youth Shelter Bed Bugs & Lice Education

Introduction

Seattle Pacific University Nursing students were assigned a fifth quarter leadership project in the greater Seattle area. Our group was assigned to a youth shelter located in Belltown, Seattle Washington. It is a thirty-bed, animal friendly shelter for young individuals looking for a safe place to stay. They offer long-term housing for those …

Indices Of Narrative Language Associated With Disability, Norah M Almubark, Gabriela Silva-Maceda, Matthew E Foster, Trina D Spencer

Faculty, Staff and Student Publications

Narratives skills are associated with long-term academic and social benefits. While students with disabilities often struggle to produce complete and complex narratives, it remains unclear which aspects of narrative language are most indicative of disability. In this study, we examined the association between a variety of narrative contents and form indices and disability. Methodology involved drawing 50 K-3 students with Individual Education Programs (IEP) and reported language concerns from a large diverse sample (n = 1074). Fifty typically developing (TD) students were matched to the former group using propensity score matching based on their age, gender, grade, mother’s education, …

Differential Contribution Of Cardiac And Peripheral Blood Flow To Metaboreceptor-Mediated Pressor Responses In Autism Spectrum Disorder, Matthew Pizano Gomez, Gabriel B. Carlota, Stephanie S. Wang, Areum K. Jensen

International Journal of Exercise Science: Conference Proceedings

Young adults with Autism Spectrum Disorder (ASD) experience a higher prevalence of hypertension than the general population. Abnormal blood pressure (BP) response to acute exercise is seen in hypertension. BP response evoked during exercise is the outcome of a central interaction between neural inputs such as the exercise pressor reflex. However, it is unclear if this neurocardiovascular interaction is altered differently to regulate BP during exercise in ASD. PURPOSE: To determine whether contributions of cardiac and peripheral blood flow to metaboreceptor-mediated pressor responses are different during exercise in ASD. METHODS: 21 young adults with and without ASD completed the study. …

Does Neuromuscular Fatigue Occur From One Doubles Pickleball Match?, Matthew Ritchey, Margaret Falknor, George Beckham, Eric Martin

International Journal of Exercise Science: Conference Proceedings

Pickleball is an emerging sport that is continuing to gain popularity among people of all ages. Little research has been completed on the performance aspects of the game. PURPOSE: Lower body force production is an important aspect of any sport. A countermovement jump is a useful way to test that characteristic. Acute decreases in force production are an indicator of fatigue. No previous research of force production and fatigue has been completed on pickleball. Therefore the purpose of this study was to test countermovement jump performance before and after a match of doubles pickleball to determine if neuromuscular fatigue …

Teaching Current And Future Professionals Techniques For Lay Communication: Validation Study Of Published Training Material, Jafra Thomas, Jasmine C. Wong, Solana R. Martin, Yi Sheng Wu

International Journal of Exercise Science: Conference Proceedings

Thomas et al. (2023), developed two mock physical activity promotion (PAP) material, which university students (and others) could practice critiquing and revising using the suitability assessment of materials (SAM) protocol. Their objective, however, was to produce mock material at two reading grade levels (11th & 8th RGL), meaning they did not compute suitability scores for other sub/main areas (eg, font size, literacy demand, respectively). PURPOSE: The purpose of the present study was to (1) establish trustworthy baseline data in other SAM sub/main areas for students to compare their own scores to (2) compare mock material SAM scores to one …

Walking With Blood Flow Restriction Elicits Postexercise Hypotension In Prehypertensive Individuals, Dae Sik Song, Geoffrey Dorsett, Justine Wills, Iridian Valdivia, Isaac Sumaran, Jong-Kyung Kim

International Journal of Exercise Science: Conference Proceedings

It is well documented that prehypertension is associated with increased risk of developing into the future hypertension and cardiovascular events. Exercise is well known as one of the best nonpharmacological treatments for prehypertension to prevent future hypertension development. Blood flow restriction (BFR) training have been known to improve health-related components of physical fitness such as body composition, muscular strength and endurance, and aerobic capacity. However, there is still paucity of research that BFR exercise induces postexercise hypotension. PURPOSE: accordingly, the goal of this study was to assess that BFR exercise is more effective in reducing blood pressure (BP) compared to …

Handgrip Strength, Pinch Grip Strength, And Screen Time In College-Age Adults And Older Adults, Zarmina Amin, Galilea Gutierrez, Larissa True

International Journal of Exercise Science: Conference Proceedings

Smartphones have become an essential part of daily life for people of all ages, serving as a vital tool for communication, information, and entertainment. However, excessive smartphone use can lead to addiction-like behavior and musculoskeletal issues, with the extent and characteristics of problematic usage varying by age. PURPOSE: The purpose was two-fold: (1) Investigate the differences in handgrip strength (HGS), pinch grip strength (PGS), and total screen time between college-age individuals (18-to-25 years old; n = 50) and older adults (50+ years old; n = 50); (2) Explore correlations between HGS, PGS, and total screen time in college-age individuals …

Investigation Into Lower Extremity Accommodation During Lbppt Submaximal Running, Ciya Clyde, Miles Mercer, Julia Freedman Silvernail

International Journal of Exercise Science: Conference Proceedings

Running is a popular sport but often leads to overuse injuries due to repetitive ground reaction forces (GRF) impacting the lower extremities. Lower Body Positive Pressure Treadmills (LBPPT) have gained popularity in clinical and research environments for their ability to reduce the runners’ bodyweight, consequently lowering the GRFs. PURPOSE: To investigate whether there is an accommodation period present during LBPPT submaximal running for lower body GRFs. METHODS: Participants (n =3; 1 male, 2 females; age: 26 ± 1.63 years; mass: 63.73 ± 7.77kg; height: 1.64 ± 0.11m) were recruited to complete three 15-minute bodyweight support (BWS) conditions at …

A Novel Waveform To Extract Exercise Gas Exchange Response Dynamics: The Chirp Waveform, Michele Girardi, Michael A. Roman, Janos Porszasz, William W. Stringer, Carrie Ferguson, Harry B. Rossiter, Richard Casaburi

International Journal of Exercise Science: Conference Proceedings

Characterizing exercise gas exchange response dynamics reveals important information about physiological control processes and cardiopulmonary dysfunction. However, current methods for extracting exercise response dynamics typically use multiple step-wise transitions, limiting applicability of this technique. PURPOSE: We designed a new protocol (chirp waveform) to extract exercise gas exchange response dynamics in a single visit. We tested the hypothesis that gas exchange response dynamics extracted from chirp forcing would be similar to those extracted from step-wise transitions. METHODS: Thirty-one participants (14 young healthy, 7 older healthy, and 10 patients with chronic obstructive pulmonary disease) visited the laboratory on three occasions. …

Low Back Demand Of Equipment Carriage Tasks In Golf, Guanrong Cai, Jacob Cho, Yunsheng Zou, Jordan Cannon, George Salem

International Journal of Exercise Science: Conference Proceedings

Low back injury is a common concern in golfers and caddies. The literature often points to the biomechanics of the golf swing as the major contributing factor; however, golfers and caddies can regularly walk upward of 10,000 steps on uneven terrain while carrying equipment, which can contribute to the cumulative load on the low back. PURPOSE: To examine the low back biomechanical demands during golf equipment carriage and pick-up tasks. METHODS: Sixteen golfers (11M/5F, 27.4±3.5yrs) participated in 3D motion capture of a golf bag pick-up task and 3 walking tasks (1. unloaded walking [UW], 2. unilateral carrying on …

The Effect Of Aicar-Induced Ampk Activation On Gene Expression In Sarcopenic Muscle, Daniel M. Rasch, Steven D. Dray, Jouber Dos Santos, Shalene E. Wilcox, David M. Thomson

International Journal of Exercise Science: Conference Proceedings

The loss of muscle mass and function (sarcopenia) afflicts 11-74% of all aging adults, with prevalence increasing with age. Exercise training is clearly effective in preventing or attenuating sarcopenia. The cellular mechanisms of exercise’s protective effects are not entirely clear, but AMP-activated protein kinase (AMPK) is thought to play an important role, in part by regulating gene expression. PURPOSE: To determine the effect of chronic pharmacological AMPK activation on skeletal muscle gene expression in sarcopenic muscle. METHODS: 24-month-old C57Bl/6J mice received either one acute injection or chronic daily saline injections of the AMPK-activating drug AICAR for 31 days. …