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Full-Text Articles in Medicine and Health Sciences

Covid-19 Newsletter (Vol. 67), Center For Disaster Medicine, New York Medical College Apr 2021

Covid-19 Newsletter (Vol. 67), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.


Covid-19 Newsletter (Vol. 66), Center For Disaster Medicine, New York Medical College Apr 2021

Covid-19 Newsletter (Vol. 66), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.


Ion Channel Candidates Mediating Orexin Neuropeptide Actions On Brainstem Serotonergic Neurons, Saqlain Javed Mar 2021

Ion Channel Candidates Mediating Orexin Neuropeptide Actions On Brainstem Serotonergic Neurons, Saqlain Javed

NYMC Student Theses and Dissertations

A loss of neurons that synthesize the neuropeptide orexin produces the sleep disorder narcolepsy with cataplexy in humans and other animals. How symptoms of this disorder arise is not well understood, but selectively restoring orexin actions at 5-HT DR neurons rescues key symptoms (cataplexy), suggesting normal orexin signaling is important at these neurons. To better understand how orexin acts on these neurons, our lab identified a set of novel orexin actions that appear mediated by unidentified cation- permeable ion channels. To narrow down the list of possible channels, we used a bioinformatics approach to compare published gene expression profiles of …