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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
How Alzheimer's Disease Is Taking Over (Your Brain), Hoda Aboueich
How Alzheimer's Disease Is Taking Over (Your Brain), Hoda Aboueich
Honors Projects
As the population continues to age and the burden on our care system grows, it is urgent to understand, treat, and cure Alzheimer’s Disease (AD). Despite decades of research, there is currently no known cause for the development of dementia or AD. There are two prominent explanations currently dominant in neuroscience: amyloid plaques and neurofibrillary tangles. I will delve into the hypotheses and definitions of each of these pathologies and specifically address how they affect overall neural activity that is proposed to result in the neurodegenerative symptoms of AD. I will also discuss the recent research surrounding biomarkers, age-related neurodegeneration, …
Epidemiology Of Island And Mainland Populations: How Does Culture Influence Health Risk Factors Of Non-Communicable, Chronic, And Metabolic Diseases?, Jake Thomas D. Palisoc
Epidemiology Of Island And Mainland Populations: How Does Culture Influence Health Risk Factors Of Non-Communicable, Chronic, And Metabolic Diseases?, Jake Thomas D. Palisoc
Honors Projects
Non-communicable diseases (NCDs), including chronic and metabolic diseases, are responsible for 74% of global mortality and are strongly influenced by health risk factors. Geographical differences in NCDs have been identified in several countries but have not been completely explained through cultural factors, specifically island and mainland cultures. This study aimed to develop an epidemiological framework for determining diseases with the highest mortality for further investigation regarding different health risk factors rooted in a specific population’s cultural foundations. Preliminary findings indicated diabetes type II (D2) and CKD caused by hypertension and D2 to have the highest risk factor and mortality percentage …
Antigenic Variation In Mycoplasma Genitalium Reduces Antibody-Antigen Association Kinetics, Suzanne M. Stafford
Antigenic Variation In Mycoplasma Genitalium Reduces Antibody-Antigen Association Kinetics, Suzanne M. Stafford
Honors Projects
Infections caused by Mycoplasma genitalium, a human genital tract pathogen, often persist for months to years. Antigenic variation of the immunodominant adhesin proteins, MgpB and MgpC, is thought to enhance persistence by avoiding specific antibody-dependent immune clearance. We used surface plasmon resonance (SPR) to study the binding of antibodies from immunized rabbits and experimentally infected primates to recombinant MgpB protein fragments. Primate antibodies collected from 2 weeks before to 2, 4, and 8 weeks after infection associated specifically with two different domains of the MgpB adherence protein (variable region B and a conserved C-terminal region) bound via amine coupling …
Health Promotion Project, Rachel Mylar, Gabi Stegemoller, Serina Dawa, Lauren Hill, Isabel St John
Health Promotion Project, Rachel Mylar, Gabi Stegemoller, Serina Dawa, Lauren Hill, Isabel St John
Nursing Leadership in Community Engagement Projects
Nursing students from Seattle Pacific University implemented a demographic and health survey and COVID-19 vaccine information pamphlet for staff and residents at at our assigned agency in Seattle, Washington. Using the nursing process, the nursing students assessed the needs of the agency using the community resources and information from the Resident Service Coordinator, then formed nursing diagnoses based on this reliable information. The nursing students continued the process by using SMART goals to plan for their community health project which included conducting and analyzing a comprehensive health survey of the population for the agency residents so that staff will have …
Determining The Genetic Control Of Neural Tube Malformation Through Genetic Interactions With Idgf3, Elli N. Fox
Determining The Genetic Control Of Neural Tube Malformation Through Genetic Interactions With Idgf3, Elli N. Fox
Honors Projects
Genetic mutations disrupting human neural tube formation can lead to birth defects such as spina bifida and anencephaly. Defects can result in lack of neural tube closure in either the caudal (spina bifida) or cranial (anencephaly) regions. Little is known about the genes that cause these malformations. Researchers have been using the model organism Drosophila melanogaster in an attempt to determine genes responsible for neural tube malformations. Recently, an ortholog of human chitin-like protein, imaginal disc growth factor 3 (Idgf3), has been identified as important in the proper formation of Drosophila egg dorsal appendages. However, the molecular mechanism responsible for …