Medicine and Health Sciences Commons^™

Effect Of Monounsaturated Fat Rich Almonds On Hemostatic And Inflammatory Factors In Healthy Adults, Kristianne M. Connell

Loma Linda University Electronic Theses, Dissertations & Projects

Background: The frequent consumption of nuts is inversely associated with the incidence of cardiovascular disease. Nuts are known to decrease the risk of cardiovascular disease by reducing serum total and low-density lipoprotein (LDL) cholesterol. Markers of inflammation including C-reactive protein, E-selectin and interleukin-6 have been proposed to be newer risk factors for cardiovascular disease. However, the influence of nuts such as almonds on markers of inflammation and hemostasis that influence cardiovascular disease risk is not currently known.

Objective: The objective of this study was to determine the effect of almond consumption on markers of inflammation and hemostatic factors in healthy …

Breathlessness Descriptors In Patients With Chronic Obstructive Pulmonary Disease Versus Congestive Heart Failure, Adelaide De Souza Caroci

Loma Linda University Electronic Theses, Dissertations & Projects

This cross-sectional descriptive study investigated breathlessness (dyspnea) in stable patients with Chronic Obstructive Pulmonary Disease (COPD) and Congestive Heart Failure (CHF). The purpose of this study was (a) to characterize the most common terms COPD and CHF patients use to describe their breathing, (b) to identify the frequency of dyspnea in patients with COPD and CHF, and (c) to determine the intensity of dyspnea in these populations.

A purposive sample of 60 patients, 30 with moderate to severe COPD and 30 patients with moderate to severe CHF, met the inclusion criteria and were enrolled in this study. The participants provided …

Effects Of Liposome-Encapsulated Tnf-Alpha And Radiation Against Colon Cancer, Dong Won Kim

Loma Linda University Electronic Theses, Dissertations & Projects

Previous studies have shown that tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation is potentially resolved with the encapsulation of TNF-α in sterically stabilized, PEGylated liposomes (STEALTH®). Thus, the overall hypothesis of the research was that the combination of radiation with STEALTH® liposome encapsulated TNF-α (SL-TNF-α) will have greater efficacy and fewer dose-limiting side effects in the LS174T human colorectal tumor xenograft model compared to the combination of free TNF-α and …