Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

Dentistry

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 4951 - 4980 of 13291

Full-Text Articles in Medicine and Health Sciences

The Association Between Mastication And Mild Cognitive Impairment In Korean Adults, Mi-Sun Kim Rdh, Bumjo Oh, Ji Won Yoo, Dong-Hun Han Dds Jun 2020

The Association Between Mastication And Mild Cognitive Impairment In Korean Adults, Mi-Sun Kim Rdh, Bumjo Oh, Ji Won Yoo, Dong-Hun Han Dds

School of Medicine Faculty Research

Currently, a few of studies revealed that there is an association between mastication and cognitive impairment. There is no study of Korean adult representative samples in relation to mastication and cognitive decline. This study was to investigate the relationship between mastication and mild cognitive impairment in Korean adults. A population-based cross-sectional study was conducted in which a total of 7029 subjects (2987 men and 4042 women) over 45 years old were surveyed from the Korea Longitudinal Study on Aging (KLoSA), Round 5th survey. Logistic regression analysis was performed for the study data controlling for confounding factors such as age, gender, …


Impact Of Covid-19 On Dental Education In The United States, Parvati Iyer, Kalid Aziz, David M. Ojcius Jun 2020

Impact Of Covid-19 On Dental Education In The United States, Parvati Iyer, Kalid Aziz, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

© 2020 American Dental Education Association Dental institutions in the United States are reeling from the consequences of the novel SARS-CoV2 coronavirus, the causative agent of CODIV-19. As oral health care providers, we have been trained on prevention of aerosol transmissible diseases, but we are still grappling with many unknown factors regarding COVID-19. While the Centers for Disease Control and Prevention (CDC), American Dental Association (ADA), and local state agencies are releasing updates on guidelines for dentists and patients, no official information exists for dental institutions on how to effectively follow the recommended guidelines including “shelter in place” with social …


Commencement Program 2020 (School Of Dentistry), Loma Linda University Jun 2020

Commencement Program 2020 (School Of Dentistry), Loma Linda University

Commencement Programs

CONTENTS

2 | Message from the President

3 | Message from the Dean

4 | University History Highlights

6 | Candidates for Degrees


Ada News - 06/01/2020, American Dental Association, Publishing Division Jun 2020

Ada News - 06/01/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Comparison Of Dna Extracted From Pediatric Saliva, Gingival Crevicular Fluid And Site-Specific Biofilm Samples, Jason Emett, Roxanne David, Jaydene Mcdaniel, Steven Mcdaniel, Karl Kingsley Jun 2020

Comparison Of Dna Extracted From Pediatric Saliva, Gingival Crevicular Fluid And Site-Specific Biofilm Samples, Jason Emett, Roxanne David, Jaydene Mcdaniel, Steven Mcdaniel, Karl Kingsley

Dental Medicine Faculty Research

(1) Introduction: Due to the non-invasive nature of saliva, many methods have been used to isolate and collect DNA from saliva samples for microbial screening. Many oral microbes also inhabit the oral biofilm, which may represent significantly different microbial constituents that may contribute to oral health and disease, including caries and periodontal disorders. Moreover, the biofilm may vary within the same patient at different sites. Few studies have evaluated the comparison between DNA isolated from saliva and DNA from site-specific biofilm, with virtually no studies addressing this analysis among pediatric patients. (2) Methods: An existing repository of paper point derived …


In Vitro And In Vivo Effects Of Concentrated Growth Factor On Cells And Tissues, Fahimeh Tabatabaei, Zahra Aghamohammadi, Lobat Tayebi Jun 2020

In Vitro And In Vivo Effects Of Concentrated Growth Factor On Cells And Tissues, Fahimeh Tabatabaei, Zahra Aghamohammadi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This article reviews the biological outcome of the concentrated growth factor (CGF), a new platelet derivative used for tissue regeneration, in published articles related to the use of this product in basic and clinical studies. An electronic literature research using PubMed and SCOPUS was performed using combination of keywords: “concentrated growth factor” (OR “CGF”), AND “stem cells,” AND “cells” OR “cell proliferation” OR “cell migration” OR “cell differentiation,” AND “repair” OR “survival” OR “revitalization,” AND “tissue” OR “bone.” Forty-five articles that were published between 2012 and 2020 met the inclusion criteria. These studies have used CGF as fresh solid form, …


Extra Nodal Rosai-Dorfman Disease Originating In The Nasal And Paranasal Complex And Gnathic Bones: A Systematic Analysis Of Seven Cases And Review Of Literature, Junu Ojha, Yeshwant B. Rawal, Jason L. Hornick, Kelly Magliocca, David R. Montgomery, Robert D. Foss, Kevin R. Torske, Brent Accurso Jun 2020

Extra Nodal Rosai-Dorfman Disease Originating In The Nasal And Paranasal Complex And Gnathic Bones: A Systematic Analysis Of Seven Cases And Review Of Literature, Junu Ojha, Yeshwant B. Rawal, Jason L. Hornick, Kelly Magliocca, David R. Montgomery, Robert D. Foss, Kevin R. Torske, Brent Accurso

School of Dentistry Faculty Research and Publications

Rosai-Dorfman disease (RDD) is a benign, self-limiting histiocytosis of unknown etiology. The classic form of the condition includes a painless cervical lymphaenopathy [sic] accompanied by fever, weight loss and an elevated ESR. Extra nodal RDD (ENRDD) is most frequent in the head and neck. Thirty-eight cases of ENRDD have been described. Seven cases of ENRDD were identified in our pathology biopsy services. The demographic and clinical information was tabulated logically on the basis of age, gender, location and presence or absence of symptoms, treatment and follow-up. Radiographic and histopathological features were also examined. The findings in these cases were correlated …


Three-Dimensional Bio-Printing And Bone Tissue Engineering: Technical Innovations And Potential Applications In Maxillofacial Reconstructive Surgery, Muhja Salah, Lobat Tayebi, Keyvan Moharamzadeh, Farhad B. Naini Jun 2020

Three-Dimensional Bio-Printing And Bone Tissue Engineering: Technical Innovations And Potential Applications In Maxillofacial Reconstructive Surgery, Muhja Salah, Lobat Tayebi, Keyvan Moharamzadeh, Farhad B. Naini

School of Dentistry Faculty Research and Publications

Background

Bone grafting has been considered the gold standard for hard tissue reconstructive surgery and is widely used for large mandibular defect reconstruction. However, the midface encompasses delicate structures that are surrounded by a complex bone architecture, which makes bone grafting using traditional methods very challenging. Three-dimensional (3D) bioprinting is a developing technology that is derived from the evolution of additive manufacturing. It enables precise development of a scaffold from different available biomaterials that mimic the shape, size, and dimension of a defect without relying only on the surgeon’s skills and capabilities, and subsequently, may enhance surgical outcomes and, in …


Role Of Iron On Physical And Mechanical Properties Of Brushite Cements, And Interaction With Human Dental Pulp Stem Cells, Sahar Vahabzadeh, Sarah Fleck, Joshua Marble, Fahimeh Tabatabaei, Lobat Tayebi Jun 2020

Role Of Iron On Physical And Mechanical Properties Of Brushite Cements, And Interaction With Human Dental Pulp Stem Cells, Sahar Vahabzadeh, Sarah Fleck, Joshua Marble, Fahimeh Tabatabaei, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Improving the physical, mechanical and biological properties of brushite cements (BrC) is of a great interest for using them in bone and dental tissue engineering applications. The objective of this study was to incorporate iron (Fe) at different concentrations (0.25, 0.50, and 1.00 wt%) to BrC and study the role of Fe on phase composition, setting time, compressive strength, and interaction with human dental pulp stem cells (hDPSCs). Results showed that increase in Fe concentration increases the β-tricalcium phosphate (β-TCP)/dicalcium phosphate dihydrate (DCPD) ratio and prolongs the initial and final setting time due to effective role of Fe on stabilizing …


Effect Of Hypoxia Preconditioned Adipose-Derived Mesenchymal Stem Cell Conditioned Medium On Cerulein-Induced Acute Pancreatitis In Mice, Kamal Abdolmohammadi, Tayebeh Mahmoudi, Shahrzad Nojehdehi, Lobat Tayebi, Seyed Mahmoud Hashemi, Farshid Noorbakhsh, Alireza Abdollahi, Masoud Soleimani, Behrouz Nikbin, Mohammad Hossein Nicknam Jun 2020

Effect Of Hypoxia Preconditioned Adipose-Derived Mesenchymal Stem Cell Conditioned Medium On Cerulein-Induced Acute Pancreatitis In Mice, Kamal Abdolmohammadi, Tayebeh Mahmoudi, Shahrzad Nojehdehi, Lobat Tayebi, Seyed Mahmoud Hashemi, Farshid Noorbakhsh, Alireza Abdollahi, Masoud Soleimani, Behrouz Nikbin, Mohammad Hossein Nicknam

School of Dentistry Faculty Research and Publications

Purpose: Acute pancreatitis (AP) is an inflammatory disorder distinguished by tissue injury and inflammation of the pancreas. Using paracrine potential of mesenchymal stem cells (MSCs) provides a useful clinical approach in treating inflammatory diseases. We investigated the therapeutic effects of adipose-derived MSC conditioned medium (CM) and hypoxia preconditioned adipose-derived MSC conditioned medium (HCM) in cerulein-induced AP in mice.

Methods: AP was induced in C57BL/6 mice by intraperitoneal injection of cerulein (75 μg/ kg/h × 7 times). One hour following the last injection of cerulein, mice were treated with intraperitoneal injection of CM and HCM (500 µL/mice/30 min × 3 times). …


Does The Method Of Visualization Impact The Performance Of A New Surgical Task In Novice Subjects?, Mikaeel Kassam, Srikant Chakravarthi, Austin Epping, Sarah Erpenbeck, Maharaj Singh, Melanie B. Fukui, Amin Kassam, Richard Rovin Jun 2020

Does The Method Of Visualization Impact The Performance Of A New Surgical Task In Novice Subjects?, Mikaeel Kassam, Srikant Chakravarthi, Austin Epping, Sarah Erpenbeck, Maharaj Singh, Melanie B. Fukui, Amin Kassam, Richard Rovin

School of Dentistry Faculty Research and Publications

Introduction

Evolution of optical technology from two-dimensional to three-dimensional (3D) systems has come with an associated loss of stereoscopy and 3D depth perception. This report compares performance of surgical tasks in unbiased subjects using these systems.

Methods

Untrained subjects were randomized into two groups, robotically operated video optical telescopic-microscope (ROVOT) or surgical microscope (microscope). Subjects sutured and tied knots. Completion time, NASA-Task Load Index (TLX), and galvanic skin responses were analyzed.

Results

Intergroup analysis of suture completion time indicated that microscope use was significantly faster compared to ROVOT, whether used first or second. Regardless of which methodology was used first, …


N Y State Dent J June-July 2020 Jun 2020

N Y State Dent J June-July 2020

The New York State Dental Journal

The New York State Dental Journal (NYSDJ) is produced by the New York State Dental Association (NYSDA) six times a year, in January, March, April, July, September and November. Each issue features clinical and scientific articles written by researchers and practitioners from around the globe and is subject to review by a panel of specialists convened by the Editor.

Issues include cover and feature articles alongside regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.


J Mich Dent Assoc June 2020 Jun 2020

J Mich Dent Assoc June 2020

The Journal of the Michigan Dental Association

Every month,The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

  • A cover story with an interview with the MDA’s 2020-21 president Dr. Stephen Meraw.
  • “Implementing Teledentistry: The Why and How” discusses the background and guidance on this important – and growing – aspect of telehealth.
  • “Key Tips in Communicating Evidence in the Clinical Setting”, another feature in our series of articles focusing on evidence-based dentistry. …


The Three-Dimensional Stable Mandibular Landmarks In Patients Between The Ages Of 12.5 And 17.1 Years, Gui Chen, Mona Al Awadi, David W. Chambers, Manuel O. Lagravère-Vich, Tianmin Xu, Heesoo Oh May 2020

The Three-Dimensional Stable Mandibular Landmarks In Patients Between The Ages Of 12.5 And 17.1 Years, Gui Chen, Mona Al Awadi, David W. Chambers, Manuel O. Lagravère-Vich, Tianmin Xu, Heesoo Oh

All Dugoni School of Dentistry Faculty Articles

Background: With the aid of implants, Björk identified two-dimensional mandibular stable structures in cephalograms during facial growth. However, we do not know what the three-dimensional stable structures are with certainty. The purpose of this study was to identify the most stable mandibular landmarks in growing patients using three-dimensional images. Methods: The sample was comprised of two cone-beam computed tomography (CBCT) scans taken about 4.6 years apart in 20 growing patients between the ages of 12.5 (T1) and 17.1 years (T2). After head orientation, landmarks were located on the chin (Pog), internal symphysis (Points C, D and E), and mandibular canals, …


Assessing Oral Health Status, Practice, And Access To Care Among War-Affected Refugees In San Antonio, Texas, David Cappelli, Rami Saadeh, Annaliese Cothron, Magda De La Torre May 2020

Assessing Oral Health Status, Practice, And Access To Care Among War-Affected Refugees In San Antonio, Texas, David Cappelli, Rami Saadeh, Annaliese Cothron, Magda De La Torre

Dental Medicine Faculty Research

Objectives: Refugees encounter several health disparities including oral health problems. This study evaluated the self-reported oral health status, practices, and access to care of adult refugees living in San Antonio, Texas, United States. Materials and Methods: Adult refugees ( n = 207) who accessed services from two centers in San Antonio, completed this survey. Multivariate logistic regression was used to examine the relationship of the refugees’ demographics with oral health status, practices, and access to care. Results: Oral pain in the previous 12 months was common among refugees having been reported by almost 58.9% of the survey participants; 43% reported …


Ada News - 05/18/2020, American Dental Association, Publishing Division May 2020

Ada News - 05/18/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


An Evaluation Of Dental Hygiene Education Of Chemotherapeutic Rinses: A Survey, Marissa Terese Aragoon May 2020

An Evaluation Of Dental Hygiene Education Of Chemotherapeutic Rinses: A Survey, Marissa Terese Aragoon

Dental Hygiene ETDs

The purpose of this study was to learn which oral chemotherapeutic rinses dental hygiene educators cover within dental hygiene curriculum. A survey was created to include dental hygiene educators responsible for oral chemotherapeutic curriculum within dental hygiene programs. Participants were asked which oral chemotherapeutic agents they included within their curriculum, their knowledge regarding several oral chemotherapeutic agents and evidence based/ non evidence based oral chemotherapeutic agents. The survey was sent to 375 dental hygiene directors and 77 (20.5%) participated in the survey study. Upon survey completion, findings suggested that the majority of dental hygiene educators teach students how to determine …


The History Of The Dental Profession - From Ancient Origins To Modern Day, Steven A. Kezian May 2020

The History Of The Dental Profession - From Ancient Origins To Modern Day, Steven A. Kezian

Pacific Journal of Health

Abstract:

This research paper explores some of the earliest known evidences of dental treatment and traveled through time discussing important figures who made vital contributions toward the development of this profession.

Dentistry is one of the oldest professions to be developed. Ever since there have been humans, there have been problems with our teeth, and we have been figuring out ways to alleviate them. The idea that there were people specializing in the healing of the teeth and oral diseases has roots to ancient pre-history and a long and fascinating saga.

This history is divided into five stages:

-Ancient pre-history …


Commentary: Phytocannabinoids As Therapeutic Agents To Combat Chronic Gingival Disease., Nick Narek Ohanian May 2020

Commentary: Phytocannabinoids As Therapeutic Agents To Combat Chronic Gingival Disease., Nick Narek Ohanian

Pacific Journal of Health

The therapeutic potential of cannabis has been harnessed for thousands of years yet the United States Food and Drug Administration (FDA) has still not approved cannabis as a safe or effective drug. The FDA has, however, approved the manufacturing of pharmaceutical drugs, which contain a “synthetic version of a substance that is present in the marijuana” and other compounds that mimic its action. A search of the US National Library of Medicine and National Institute of Health for keywords “CBD” and “Periodontitis” together yields only 2 publications. Although the current State and Federal regulations on the use of cannabis for …


Efficacy Of An Anhydrous Stannous Fluoride Toothpaste For Relief Of Dentine Hypersensitivity: A Randomized Clinical Study, Danying Tao, Martin R. Ling, Xi-Ping Feng, John Gallob, Audrey Souverain, Wenjie Yang, Anousheh Alavi May 2020

Efficacy Of An Anhydrous Stannous Fluoride Toothpaste For Relief Of Dentine Hypersensitivity: A Randomized Clinical Study, Danying Tao, Martin R. Ling, Xi-Ping Feng, John Gallob, Audrey Souverain, Wenjie Yang, Anousheh Alavi

Dental Medicine Faculty Research

Aim To compare efficacy of an anhydrous 0.454% w/w stannous fluoride/sodium fluoride toothpaste (Test) versus a sodium monofluorophosphate toothpaste (Negative control) and a stannous chloride/sodium fluoride toothpaste (Positive control) for dentine hypersensitivity relief after 8 weeks’ twice-daily use. Materials and Methods In this randomized, examiner-blind, stratified, parallel study, primary and secondary efficacy variables were mean changes in Schiff score (evaporative [air] sensitivity) and tactile threshold (Yeaple probe), respectively, from baseline to Week 8 between Test (n = 62) and Negative control (n = 62). Test and Positive control (n = 61) comparisons were exploratory objectives. Results All groups significantly improved …


A Nondestructive Procedure For The Extraction Of Dna From Human Teeth, Mark Reliquias, Ann-Elodie Black May 2020

A Nondestructive Procedure For The Extraction Of Dna From Human Teeth, Mark Reliquias, Ann-Elodie Black

Honors Theses

This research focuses on constructing a procedure that allows for the nondestructive extraction of mtDNA from teeth for forensic DNA analysis. Currently, only a destructive method for extracting DNA from teeth is used in the forensic laboratory to identify an individual. A disadvantage of extracting DNA through a destructive method is the complete or partial loss of the tooth. To extract DNA through a destructive method, the tooth must either be cut horizontally or vertically to access the pulp, or the root ground into a powder to extract DNA from the dentine-cementum. With the destruction of the tooth, additional forensic …


Factors Which Influence The Education Of Local Anesthesia In Dental Hygiene, Angela D. Cook, Angela D. Cook May 2020

Factors Which Influence The Education Of Local Anesthesia In Dental Hygiene, Angela D. Cook, Angela D. Cook

Dental Hygiene ETDs

ABSTRACT Dental hygienists, like most students, learn according to formal curriculum that is defined by goals, competencies, and required subject matter for examinations.1 They also learn through an intense socialization process known as “the hidden curriculum”. The “hidden curriculum” is not defined in student textbooks nor classroom lectures, but is demonstrated through case studies, research, and an experience shared between colleagues.1 The purpose of this study was to assess the determining factors that influence what dental hygiene instructors are teaching hygiene students on the use of articaine when administering dental blocks, and to assess if the “hidden curriculum” …


Analysis Of Different Characteristics Of Smile, Mehwish Khan, Syed Murtaza Raza Kazmi, Farhan Raza Khan, Imran Samejo May 2020

Analysis Of Different Characteristics Of Smile, Mehwish Khan, Syed Murtaza Raza Kazmi, Farhan Raza Khan, Imran Samejo

Section of Dental-Oral Maxillofacial Surgery

Introduction: Analysis of smile is imperative in the diagnosis and treatment planning phases of aesthetic dentistry.
Aim: To evaluate the components of smile among students of a dental institution.
Methods: Frontal view digital photographs with posed smile of 157 dental students were assessed using Adobe Photoshop7.0. Smile characteristics evaluated included; smile line, smile arc, smile design, upper lip curvature, labiodental relationship and number of teeth displayed. Data were analyzed using SPSS version 23.0. Pearson chi-square test was used to determine the gender based differences for various parameters.
Results: Average smile line (43.3%), consonant smile arcs (45.2%), cuspid smiles (45.9%), upward …


Ada News - 05/04/2020, American Dental Association, Publishing Division May 2020

Ada News - 05/04/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Replacing A Single Tooth: Single Implant Vs. Three Unit Bridge, Ibeth Erazo, Aneeza Hussain May 2020

Replacing A Single Tooth: Single Implant Vs. Three Unit Bridge, Ibeth Erazo, Aneeza Hussain

Publications and Research

There are more than two options for restoring a single tooth but our research includes a three-unit bridge and a single-tooth implant as the main options. In this paper, we discuss the advantages and disadvantages of these methods and the factors that must be considered when choosing between them for the replacement of a single tooth. Although in some cases a three-unit bridge is the most appropriate choice, implants have the advantage of allowing preservation of the integrity of sound teeth adjacent to the edentulous area. Many factors must be considered when choosing between a three-unit bridge and an implant …


Using Active Learning Techniques To Improve Oral Health Literacy Among Children In Vulnerable Populations., Sarah Maria Downes May 2020

Using Active Learning Techniques To Improve Oral Health Literacy Among Children In Vulnerable Populations., Sarah Maria Downes

Electronic Theses and Dissertations

This thesis examines the effectiveness of an active learning approach in improving oral health literacy and attitude about science among at-risk students in the age range of third to sixth grades. This is done by designing and implementing a novel Oral Health Outreach module and video. Active learning components include engaging PowerPoint, oral hygiene discussion and demonstration, and finally a biofilm simulation, which utilizes glow-in-the-dark paint, dentoform models, and black lights that allow students to visualize the importance of plaque removal. Student comprehension of oral health concepts increased by an average of 52.4% on post-tests (n=61, p


The Emerging Oral Pathogen, Filifactor Alocis, Disrupts Neutrophil Functions To Enhance Survival And Dysregulate Inflammation., Irina Miralda Molina May 2020

The Emerging Oral Pathogen, Filifactor Alocis, Disrupts Neutrophil Functions To Enhance Survival And Dysregulate Inflammation., Irina Miralda Molina

Electronic Theses and Dissertations

Periodontitis is an irreversible, chronic inflammatory disease where pathogenic microbial communities accumulate in the gingival crevice. Advances in culture-independent techniques have facilitated the identification of new bacterial species in periodontal lesions, such as the Gram-positive anaerobe, Filifactor alocis. Neutrophils are a major component of the innate host response, and the outcome of their interaction with F. alocis may be a determinant of oral health status. While neutrophil functions typically protect the host against periodontal disease, oral pathogens have adapted to evade or disarm neutrophil microbicidal functions while promoting mechanisms that drive inflammation, which also provides a source of nutrients …


New Dentist News (May 2020), Ada Committee On The New Dentist May 2020

New Dentist News (May 2020), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.


Functionalizing Nanoparticles With Cafa Protein To Target Bar Peptide For Oral Delivery Applications., Hetal Desai May 2020

Functionalizing Nanoparticles With Cafa Protein To Target Bar Peptide For Oral Delivery Applications., Hetal Desai

Electronic Theses and Dissertations

Background: Porphyromonas gingivalis adherence to Streptococcus gordonii may be important for P. gingivalis colonization in the oral cavity. Nanoparticles encapsulating synthetic peptide BAR (BAR-NPs) inhibit P. gingivalis adherence more potently than free BAR. However, BAR-NPs would exhibit low retention in an open flow environment. Hypothesis: Targeting BAR-NPs to the streptococcal surface using CafA protein will enhance their efficacy. Methods: CafA-modified NPs encapsulating BAR were synthesized using double emulsion approach. Surface binding and retention, and release kinetics of BAR from CafA-modified NPs was assessed. Functional inhibition assays were performed using dual a species biofilm. Results: CafA-modified NPs demonstrated specificity of adhesion, …


Tobacco Enhances Bacterial-Induced Periodontal Bone Loss In Mice., Mina Iskander May 2020

Tobacco Enhances Bacterial-Induced Periodontal Bone Loss In Mice., Mina Iskander

Electronic Theses and Dissertations

Background: Tobacco smoking is the leading environmental risk factor for periodontal diseases. Delineation of the mechanisms underlying tobacco-induced or exacerbated periodontitis is hampered by the lack of an appropriate and reliable animal model. Hypothesis: We hypothesized that Porphyromonas-gingivalis-infected, cigarette smoke-exposed mice would represent reproducible models of acute (ligature model) and chronic (oral gavage model) tobacco-enhanced periodontitis that reflect multiple aspects of the disease noted in human smokers. Methods: In a chronic oral gavage disease model, Balb/c mice (6-8 weeks, 4 groups of n = 6 per group) were exposed to smoke produced by a Teague-10 smoking machine from 1R6F research …