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Full-Text Articles in Medicine and Health Sciences
Reproducing Published Results From In Silico Computer Models Of The Acute Inflammatory Response To Severe Sepsis, Wayne W. Wakeland, Joe Fusion, Brahm Goldstein
Reproducing Published Results From In Silico Computer Models Of The Acute Inflammatory Response To Severe Sepsis, Wayne W. Wakeland, Joe Fusion, Brahm Goldstein
Systems Science Faculty Publications and Presentations
Recent studies describe computer simulation models of the acute or systemic inflammatory response (AIR or SIR) to severe sepsis, a condition that can lead to multiple organ failure and death. One study used an agent-based model, while the other used differential equations (DEs) to simulate a randomized clinical trial. Both studies obtained results similar to the actual results from a successful clinical drug trial of severe sepsis, suggesting that in silico (simulated) randomized clinical trials may be used to design more effective in vivo clinical trials.
A Tale Of Two Methods—Agent-Based Simulation And System Dynamics— Applied In A Biomedical Context: Acute Inflammatory Response, Wayne W. Wakeland, Joe Fusion, Brahm Goldstein
A Tale Of Two Methods—Agent-Based Simulation And System Dynamics— Applied In A Biomedical Context: Acute Inflammatory Response, Wayne W. Wakeland, Joe Fusion, Brahm Goldstein
Systems Science Faculty Publications and Presentations
Three specific models of the acute inflammatory response were contrasted. The first model was a recently published and rather complex agent-based model used to simulate clinical trials in silico. The second model was a highly simplified system dynamics model developed during the present research. The third model was also recently published, with similar objectives to the first model, but utilized a complex set of 18 differential equations. The study found that the complexity of the first and third models is likely to adversely impact their usefulness, at least for other researchers. The second model, which is too simple to …