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Full-Text Articles in Medicine and Health Sciences
Key Players In Reverse Cholesterol Transport: The Plasma Enzyme Lcat, Christopher J. Pechura
Key Players In Reverse Cholesterol Transport: The Plasma Enzyme Lcat, Christopher J. Pechura
Undergraduate Research Posters 2012
Lecithin cholesterol acyltransferase (LCAT) is a plasma enzyme that remodels nascent high density lipoprotein (HDL) into a mature form called spherical HDL. The model will be used in the future to map the amino acid residues from LCAT and the protein component of nascent HDL (apoA1) involved in mutual interaction, and to identify LCAT residues interacting with the lipid phase of nascent HDL.
Biological Evaluation Of Cyclooxygenase-2 Inhibitor Nimesulide Derivatives As Anti-Agents, Amandeep Singh, Snigdha Chennamaneni
Biological Evaluation Of Cyclooxygenase-2 Inhibitor Nimesulide Derivatives As Anti-Agents, Amandeep Singh, Snigdha Chennamaneni
Undergraduate Research Posters 2012
Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. A series of new nimesulide analogs were evaluated with cell proliferation assay based on a non-small lung cancer cell line H292. The results showed that several derivatives were very active to against H292 cell growth with IC50s of sub nano mole. These results suggest the possibility of using these nimesulide derivatives as chemo preventive agents.
Obtaining A Pure Protein Using An Elp-Tagged Tev Protease, Teisha L. Mullins
Obtaining A Pure Protein Using An Elp-Tagged Tev Protease, Teisha L. Mullins
Undergraduate Research Posters 2012
We present here use of GLGVP for tagging and purifying a gadolinium binding protein domain.
Understanding The Structure Of High Density Lipoprotein, Dmitriy Parshakov, Kayla T. Tran
Understanding The Structure Of High Density Lipoprotein, Dmitriy Parshakov, Kayla T. Tran
Undergraduate Research Posters 2012
The high-density lipoprotein (HDL), the carrier of ‘good cholesterol’, transports cholesterol from periphery cells to liver for catabolism, a process termed reverse cholesterol transport. In this project we focused on obtaining and characterizing HDL particles.