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Full-Text Articles in Medicine and Health Sciences

Reviewing Existing Knowledge Prior To Conducting Animal Studies, Andrew Knight Dec 2008

Reviewing Existing Knowledge Prior To Conducting Animal Studies, Andrew Knight

Experimentation Collection

Highly polarised viewpoints about animal experimentation have often prevented agreement. However, important common ground between advocates and opponents was demonstrated within a discussion forum hosted at www.research-methodology.org.uk in July–August 2008, by the independent charity, SABRE Research UK. Agreement existed that many animal studies have methodological flaws — such as inappropriate sample sizes, lack of randomised treatments, and unblinded outcome assessments — that may introduce bias and limit statistical validity. There was also agreement that systematic reviews of the human utility of animal models yield the highest quality of evidence, as their reliance on methodical and impartial methods to select significant …


Faecal-Centric Approaches To Wildlife Ecology And Conservation; Methods, Data And Ethics, C. T. Darimont, T. E. Reimchen, H. M. Bryan, P. C. Paquet Dec 2008

Faecal-Centric Approaches To Wildlife Ecology And Conservation; Methods, Data And Ethics, C. T. Darimont, T. E. Reimchen, H. M. Bryan, P. C. Paquet

Ethics and Conservation Biology Collection

Abundant and commonly encountered in the field, wildlife faeces have long attracted scientists. Recent advances in molecular techniques, however, especially when coupled with creative study designs, can now yield a great variety of high quality data. Herein, we review the opportunities and challenges of faecal-centric approaches to address ecological and conservation questions using wolves of coastal British Columbia, Canada, as a case system. We begin by discussing methodological considerations, which should have broad applicability to any wildlife study system. We then summarize the extensive and unique variety of data that has emerged from our ‘facts from faeces’ approach with wolves, …


Arkansas Animal Science Department Report 2008, Zelpha B. Johnson, D. Wayne Kellogg Dec 2008

Arkansas Animal Science Department Report 2008, Zelpha B. Johnson, D. Wayne Kellogg

Arkansas Agricultural Experiment Station Research Series

No abstract provided.


Behavioural Analysis Of A Nociceptive Event In Fish: Comparisons Between Three Species Demonstrate Specific Responses, Siobhan C. Reilly, John P. Quinn, Andrew R. Cossins, Lynne U. Sneddon Nov 2008

Behavioural Analysis Of A Nociceptive Event In Fish: Comparisons Between Three Species Demonstrate Specific Responses, Siobhan C. Reilly, John P. Quinn, Andrew R. Cossins, Lynne U. Sneddon

Sentience Collection

Nociception is the sensory mechanism by which potentially harmful stimuli are detected in animals and humans. The behavioural responses to noxious stimulation have been studied in two fish species thus far. However, since species-specific differences are seen in mammals, more species need to be examined to determine whether nociceptive responses are generic in fish. The present study investigated the behavioural and respiratory response to an acute noxious or potentially painful stimulus in common carp (Cyprinus carpio), zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss). Behavioural parameters such as frequency of swimming, use of cover and any anomalous behaviour were measured …


Amyloid Fibrils: Potential Food Safety Implications, Michael Greger Jan 2008

Amyloid Fibrils: Potential Food Safety Implications, Michael Greger

Human Health Collection

The demonstration of oral Amyloid-A (AA) fibril transmissibility has raised food safety questions about the consumption of amyloidotic viscera. In a presumed prion-like mechanism, amyloid fibrils have been shown to trigger and accelerate the development of AA amyloidosis in rodent models. The finding of amyloid fibrils in edible avian and mammalian food animal tissues, combined with the inability of cooking temperatures to eliminate their amyloidogenic potential, has led to concerns that products such as pâté de foie gras may activate a reactive systemic amyloidosis in susceptible consumers. Given the ability of amyloid fibrils to cross-seed the formation of chemically heterologous …


An Hsus Report: Human Health Implications Of Intensive Poultry Production And Avian Influenza, The Humane Society Of The United States Jan 2008

An Hsus Report: Human Health Implications Of Intensive Poultry Production And Avian Influenza, The Humane Society Of The United States

Impact of Animal Agriculture

The high stocking density, stress, unhygienic conditions, lack of sunlight, and breeding practices typical of industrial poultry and egg production systems may facilitate the emergence and spread of diseases, including highly pathogenic avian influenza viruses with public health implications such as H5N1.


An Hsi Report: Human Health Implications Of Intensive Poultry Production And Avian Influenza, Humane Society International Jan 2008

An Hsi Report: Human Health Implications Of Intensive Poultry Production And Avian Influenza, Humane Society International

HSI REPORTS

The high stocking density, stress, unhygienic conditions, lack of sunlight, and breeding practices typical of industrial poultry and egg production systems may facilitate the emergence and spread of diseases, including highly pathogenic avian influenza viruses with public health implications such as H5N1.


An Hsus Report: Human Health Implications Of Non-Therapeutic Antibiotic Use In Animal Agriculture, The Humane Society Of The United States Jan 2008

An Hsus Report: Human Health Implications Of Non-Therapeutic Antibiotic Use In Animal Agriculture, The Humane Society Of The United States

Impact of Animal Agriculture

For decades, the U.S. meat industry has fed medically important antibiotics to chickens, pigs, and cattle to accelerate their weight gain and prevent disease in the stressful and unhygienic conditions that typify industrialized animal agriculture production facilities. A strong scientific consensus exists, asserting that this practice fosters antibiotic resistance in bacteria to the detriment of human health. In response to this public health threat, the European Union has banned the non-therapeutic feeding of a number of antibiotics of human importance to farm animals. Given these serious concerns as well as recent data that suggest an overall lack of financial benefit, …