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Full-Text Articles in Medicine and Health Sciences
Empagliflozin In The Treatment Of Type 2 Diabetes: Evidence To Date, Jay H. Shubrook, Babak Baradar Bokaie, Sarah E. Adkins
Empagliflozin In The Treatment Of Type 2 Diabetes: Evidence To Date, Jay H. Shubrook, Babak Baradar Bokaie, Sarah E. Adkins
Faculty Publications & Research of the TUC College of Osteopathic Medicine
In the last decade, researchers have gained a greater understanding of the pathophysiologic mechanisms of type 2 diabetes as a chronic and progressive disease. One of the more recent treatment targets is the kidney. The kidneys become maladaptive in diabetes by increasing the reabsorption of glucose above the normal physiologic renal threshold. This discovery has led to the development of the sodium/glucose cotransporter 2 inhibitors (SGLT2). These agents readjust the renal threshold for glucose reabsorption to a lower level and decrease glucose reabsorption, while increasing urinary glucose when the glucose is above the renal threshold and subsequently lowering plasma glucose. …
Vigorous Exercise Effect On Cardiovascular Health, Aryeh Mahana
Vigorous Exercise Effect On Cardiovascular Health, Aryeh Mahana
The Science Journal of the Lander College of Arts and Sciences
Many studies examine the effects of vigorous cardiovascular exercise on the heart. Intense exercise causes frequent muscle contractions in the heart and specific biomarkers that usually signify a myocardial infarction are released into the bloodstream. However, studies indicate that there might not be a correlation between the release of biomarkers and cardiac function. Another study shows that long term vigorous exercise negatively affects the heart by dramatically increasing the mass and volume of the right and left ventricles, thereby resulting in hypertrophy. The cardiac hypertrophy is still evident even after the subjects have stopped exercising. Cardiac hypertrophy results in myocardial …