Medicine and Health Sciences Commons^™

Development Of A Novel Serum Formulation For The Treatment Of C. Acnes, Ariana G. Ngue

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

Acne impacts 85% of people between 12-24 years of age. Even after puberty, acne continues to impact a large portion of the population. The treatments are diverse and include prescription drugs. Through this research, a novel formulation was created for the skin to treat acne. This formulation incorporates salicylic acid, a non-prescription acne treatment, as well as a polymeric carbohydrate (hyaluronic acid) known to be a component of skin and involved in the healing of skin. Through an internship with Island Lux Essentials, a company devoted to making all natural body care products, a novel serum formulation was created to …

In Silico Prediction Of Sodium-Glucose Co-Transporter-2 (Sglt2) Inhibition Activity By Allium Fistulosum Compound Based On Skelspheres Molecular Descriptor, Rudy Heryanto, Aryo Tedjo, Dimas Noor

Indonesian Journal of Medical Chemistry and Bioinformatics

The Sodium-Glucose co-transporter-2 (SGLT2) inhibitor represents a novel agent for the treatment of type 2 diabetes. Drugs of this class function by inhibiting glucose reabsorption in the kidneys, thereby controlling blood glucose levels. It is known that SGLT2 inhibitors activate the AMPK signaling pathway by increasing the expression and activity of AMP-activated protein kinase (AMPK). In vivo tests have demonstrated that ethanolic and aqueous extracts of Welsh onion leaves (Allium fistulosum L) can reduce body weight, liver weight, adipocyte size, and enhance AMP-activated protein kinase (AMPK) expression. In this study, the inhibitory activity (IC50) of compounds within Allium fistulosum against …

Are You Blue: The Key To Living To 100, Lauren Ulsas

BUHealth

There are five locations in the world that have the highest rates of centenarians in the world. A centenarian is an individual who lives until the age of 100. These places have been entitled “the blue zones”. While these blue zones are located all throughout the globe, there are certain commonalities among them. Some common practices of the individuals living in these locations include leading an active life, eating well, establishing strong bonds, and feeling a sense of purpose. In theory, these practices may sound easy, but there are several limitations and barriers that prevent those living outside of these …

Honey: The Sweet Truth, Alex Szewczyk

BUHealth

Honey is a natural food that is packed with vitamins, minerals, enzymes, proteins, organic acids, and many other biologically active compounds. Its exact components may vary based on the unique collection of flowers and plants that honeybees pollinate. The nutrient dense quality of honey has different health benefits. People all around the world are currently suffering from chronic illnesses such as obesity, diabetes, hypertension, and dyslipidemia at unprecedented rates. When patients experience a combination of these disease states, it is known as metabolic syndrome (MetS). MetS is correlated with urbanization in developing countries, with sedentary lifestyle and poor diet as …

Zen Your College Experience, Anna Sharshon

BUHealth

When college students transition from life at home to life at school, they may be faced with a variety of stressors such as navigating a more rigorous academic environment or an overload of new commitments and responsibilities. Struggling with the change in environment is one of the major problems faced among college students and often leads to more stress and anxiety, lack of sleep hygiene, and poor eating habits. Fortunately, mindful meditation has been proven to help with these issues. Mindful meditation is the practice of focusing or clearing the mind by using certain mental and physical techniques. It has …

Are You Down To Earth?, Karmen Koch

BUHealth

The practice of grounding, or “earthing” has been gaining popularity in the last few decades as a holistic approach to prevention and treatment in broad scopes of practice. The exercise reflects the early human experience of frequent and direct contact with the earth’s surface. The current, limited available data perceives and theorizes health improvements including decreased inflammation, enhanced perfusion, sleep restoration, lowered blood pressure, enhanced muscle recovery, and decreased cortisol levels. When implementing any new health practice into one’s routine, it is crucial to be well informed. This review can help individuals better ascertain if grounding could improve their health …

Metabolomic Insights Into Tuberculosis: Machine Learning Approaches For Biomarker Identification, Miftahul Khair Akbar, Arief Aulia Rahman

Indonesian Journal of Medical Chemistry and Bioinformatics

The lung parenchyma is largely impacted by the infectious condition known as pulmonary tuberculosis (pulmonary TB) when the immune system creates a wall around the germs in the lungs, a tiny, hard bulge known as a tubercle develops, earning the disease the name tuberculosis. Although the majority of TB germs target the lungs, they can also harm other bodily organs. The identification of TB biomarkers, which are crucial for diagnosis, treatment monitoring, risk analysis, and prognosis, has been the subject of extensive research. Differences in metabolites between normal cells and tuberculosis are considered to be able to support the diagnosis …

Effectiveness Of Thyme Honey In The Management Of Xerostomia In Geriatric Patients With End-Stage Renal Disease: A Randomized Controlled Clinical Trial With A Biochemical Assessment, Asmaa Ras, Dalia M. Ghalwash, Radwa R. Hussein, Suzan M. Seifallah

Dentistry

Background

Taking into consideration the value of the oral health condition in geriatric people with end-stage renal disease (ESRD) associated with xerostomia and believing that salivary stimulants or substitutes could potentially be used to manage this condition. This study aimed to evaluate the clinical effectiveness of thyme honey as oral rinse in geriatric patients with ESRD using the subjective dry mouth score as a primary objective and to assess the effect of thyme honey on the salivary nitric oxide level, salivary flow rate, and salivary ph in addition to objective dry mouth score as a secondary objective.

Methods

This was …

The Effects Of Herbal Products In Cartilage Healing And Reducing The Progression Of Osteoarthritis, Mariya Baig, Mir Saleem

Mako: NSU Undergraduate Student Journal

Treatment for osteoarthritis (OA) includes symptom management with nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen. However, these drugs pose health risks for long-term use, such as contraindications and gastrointestinal/cardiovascular issues. This systematic review of the literature was conducted to evaluate the impact of the herbal products, turmeric and ginger, in cartilage healing and reducing the progression of OA. It was found that turmeric and ginger can aid in symptom management for OA and promote cartilage regeneration, with turmeric extract yielding greater evidence-based results. Turmeric reduces the amount of pain and stiffness experienced from OA and can restore cartilage by subduing …

Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian

Master's Theses

As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …

Thymoquinone Inhibits Prostate Cancer Progression By Modulating Cytochrome P450 (Cyps), Santosh K. Singh, Rajesh Singh

Research Symposium

Background: Prostate cancer (PCa) incidence and mortality remain high in African American (AA) than Caucasian American (CA) men. Multiple factors contribute to this critical disease disparity, androgen receptors (AR), and differences among variants of the genes such as Cytochrome P450 (CYP) are involved in androgen biosynthesis and metabolism that may switch to gene regulation for prostate growth. However, inhibitors have been approved for CYP genes, the major pitfall, undesirable side effects, and quality of life in those patients. Therefore, targeting CYPs with a natural compound, Thymoquinone (TQ), a constituent of Nigella sativa (black seed), potentially safe and curative option for …

Targeting Cellular Signaling Pathways In Cancer By Lactobacilli, Varish Ahmad, Aftab Ahmad, Quazi Muhammad Sajid Jamal

Research Symposium

Purpose: Presenting lactobacilli therapy for cancer treatment targeting cancer signaling Lactobacilli as Probiotic lactic acid bacteria (LAB) are a group of fermentative gram-positive and gram-negative bacteria that produces a large number of intracellular and extracellular metabolites used in the food manufacture industry as well as complementary and alternative medicines against many diseases including cancer.

Description: Some LAB has been found to have inhibitory activity against colon liver cancer, cancer, colorectal cancer, breast cancer, and lung cancer in vivo or in vitro. These fermentative bacteria induced the autophagy cell death either by GRP78 and Beclin-1 or by induction of Bak …

Stress-Induced Changes In Carf Expression Determine Growth Arrest, Apoptosis, Or Malignant Transformation In Cultured Human Cells: Molecular Evidence And Its Application, Mallika Khurana, Rajkumar Singh Kalra, Anupama Chaudhary, Amr Omar, Xiaoshuai Li, Sunil C. Kaul, Renu Wadhwa

Research Symposium

Background: CARF (Collaborator of ARF)/CDKN2AIP is an essential protein, first cloned as a binding partner of ARF. It was subsequently shown to interact with p53, HDM2 proteins and regulate growth arrest and apoptosis by its multimodal mechanism of action. Over-expression of CARF caused senescence like growth arrest of cells, its knock-down triggered apoptosis. Intriguingly, malignantly transformed cells showed high level of CARF expression. Based on these findings, we hypothesized that level of CARF expression may be a key determinant of cell proliferation fates; where an increase in its levels causes growth arrest/senescence, but beyond a threshold it activates carcinogenesis.

Methods: …

Piperine Encourages Apoptosis In Human Cervical Adenocarcinoma Cells Through Ros Generation, Dna Fragmentation, Caspase-3 Activation And Cell Cycle Arrest, Asif Jafri, Juhi Rais, Sudhir Kumar, Md Arshad

Research Symposium

Background: Cancer is one of the most common destructive diseases and the second leading cause of death in humans. Among cancer, cervical cancer is the second most common malignancy among women globally. Thus, there is a continuous need to search for chemotherapeutic chemicals or naturally occurring drugs to resolve this global health problem. Piperine (1-piperoylpeperdine) is present in the fruits of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). It possesses several pharmacological properties and in the present study we have evaluated its anti-cancer potential on human cervical adenocarcinoma (HeLa) cells.

Methods: The anti-proliferative effect …

Development And Evaluation Of A Nanofiber Membrane In Vitro As A Therapeutic Alternative For The Post Treatment In Breast Cancer Cell In A Murine Model, Bruno A. Valades-Aguilar, Diana Ginette Zarate-Triviño, José Raúl Rángel-López, Moises Armides Franco-Molina, Jorge Luis Menchaca-Arredondo, María Cristina Rodríguez-Padilla

Research Symposium

Worldwide female breast cancer is the most commonly diagnosed cancer, with an estimated 2.3 million new cases in 2020, reason for the need of targeted therapies that can maximize treatment success and minimize toxicity. Nanoparticles of gold (AuNps) exhibit cytotoxic properties against certain types of cancer cell lines. Nanofibers have been use in the drug delivery systems due to its degradability and high surface area. We proposed a membrane with nanometric fibers using polivinilic alcohol (PVA) and chitosan (Qts) loaded with AuNps and Doxorubicin (Doxo) with the purpose of diminish tumor regression.

PVA-Qts membrane was develop with electrospinning, the injection, …

Mucocele Of Lower Lip Treated With Constitutional Homoeopathic Medicine Silicea – A Case Report, Uma Maheswari M.S, Sisir P R, Gopukumar S T

Indian Journal of Research in Homoeopathy

Introduction: A mucocele is a mucus-containing benign cystic lesion of the salivary gland. Based on the histological features, they are classified into two types, mucous retention cysts and mucous extravasation cysts. They appear in the minor salivary glands due to mechanical damage to the gland or its duct. The case study presented here is a detailed analysis of a 6-year-old male child affected by mucocele of the lower lip and its homoeopathic treatment and significance. Case Summary: A 6-year-old child presented with complaint of a swelling over the mucosa of the lower lip. Initially, the swelling was small, …

Recognition Of Evidence-Based Traditional And Complementary Medicine (Tcm) In G20 New Delhi Leaders’ Declaration: Pointers For Homoeopathy, Subhash Kaushik

Indian Journal of Research in Homoeopathy

India just wrapped up its G20 presidency role, but not without key commitments for a promising future. It was, indeed, a heartening sight to see all twenty countries of the G20 group together on one platform, united to fight and address various global matters – with the theme ‘वसुधैव कुटुंबकम’, meaning ‘One Earth, One Family, One Future’ at the core of all discussions. The comprehensive document, G20 New Delhi Leaders’ Declaration: Strengthening Global Health, and Implementing One Health Approach covers various aspects of global development and stability. Interestingly, under the subject ‘Strengthening Global Health and Implementing One Health Approach’, the …

Individualised Homoeopathic Medicine Versus Placebo In The Pain Management Of Knee And Hip Osteoarthritis: A Double-Blind, Randomised Controlled Trial, Azizul Islam Khadim, Vivek Kumar Shail, Kanak Kumar, Sabiha Naaz, Abhijit Chakma

Indian Journal of Research in Homoeopathy

Background: Osteoarthritis (OA) is a progressive, degenerative disease affecting large weight-bearing joints. The severity of symptoms varies among individuals; whereas pain and stiffness are the most troublesome complaints. Homoeopathic medicines have the potential to manage pain episodes. Objective: The aim of the study was to assess the effect of individualised homoeopathic medicine (IHM) in managing the pain of knee and hip OA. Methods: A prospective, double-blind, randomised (1:1) placebo-controlled trial was conducted on 60 individuals suffering from OA at R.B.T.S. Govt. Homoeopathic Medical College and Hospital, Muzaffarpur. Visual analogue scale for pain (Score-A-1), stiffness (Score-A-2) and loss …

Homoeopathic Management Of Non-Responsive, Nodulocystic Acne: A Case Report, Padmalaya Rath, Indu Shukla

Indian Journal of Research in Homoeopathy

Introduction: Nodulocystic acne is a severe form of acne that can significantly damage the skin and impact the quality of life. Although oral isotretinoin is considered an effective conventional treatment for such cases, it often fails. A case of severe facial nodulocystic acne is reported here, where allopathic treatment failed to control the condition. Homoeopathic treatment was administered, and the patient improved. Case Summary: A 16-year-old female patient presented with pustular, nodular, cystic and painful eruptions on the face, which were treated with individualised homoeopathic medicine Tarentula cubensis. The symptoms improved without any relapse. The causal attribution of …

Effectiveness Of Individualised Homoeopathic Intervention In Warts – A Case Series, Dastagiri P, Chakravarthy S.G.S, Renu Mittal

Indian Journal of Research in Homoeopathy

Verruca vulgaris, also known as common warts, is benign lesions caused by the non-malignant human papillomavirus, affecting approximately 10% of the population globally. It may range from 1 mm to several cm, and are mostly seen on the extremities, followed by the face. They may be transmitted by direct or indirect contact and lead to cosmetic concerns, itching and mild to severe pain while doing activities. Conventional treatment has destructive therapies such as salicylic acid, cauterisation and cryosurgery, which induce many adverse effects from local to general. However, an individualised homoeopathic approach can be used to effectively treat these warts, …

Tinea Cruris Treated With Individualised Homoeopathic Medicine – An Evidence-Based Case Report, Yogeshwari Gupta, Arvind Sharma, Samridhi Sharma

Indian Journal of Research in Homoeopathy

Introduction: Tinea cruris, also commonly known as jock itch, is a skin infection caused by dermatophytes which are pathogenic fungi affecting genital, pubic, perineal and perianal areas. Tinea cruris more commonly affects men and affects adults more than children. Conventional management involves the use of topical antifungal agents and oral therapy in extensive cases. Case Summary: A case of tinea cruris in a 30-year-old male patient is reported, which was effectively treated with individualised homoeopathic medicine. Based on the totality of symptoms, the homoeopathic medicine Natrum muriaticum in 200C potency was prescribed as the first dose and improvement …

Physicochemical Standardisation Of The Homoeopathic Drug, Apis Mellifica: A Preliminary Attempt, Bibaswan Biswas, Satyajit Maity, En Sundaram, Gv Narasimha Kumar, Satish Patel

Indian Journal of Research in Homoeopathy

Background: Unlike the mainstream biomedical system, honeybees’ therapeutic use has long been well documented in the homoeopathic system. The medicine prepared from the whole honeybee, Apis mellifica, is on the Essential Drug List. Objective: An in-depth physicochemical standardisation of this homoeopathic drug is attempted. Material and Methods: In this study, first the raw drug was authenticated, and then its pharmacopoeial parameters were measured, e.g. moisture content, foreign matter, different ash values, alcohol and water-soluble extractive values. Further, the mother tincture of Apis mellifica was prepared from the authentic raw drug. The pharmacopeial parameters of in-house mother tincture …

Homoeopathic Medicines Modulate Inflammatory Functions And Adhesion Receptor Expression In Human Blood Cells: An In Vitro Study, Nibedita Dalpati, Shubham Kumar Rai, Divya Singh, Shiba Prasad Dash, Sukanti S. Sarangi, Mahabahu Nayak, Pranita P. Sarangi

Indian Journal of Research in Homoeopathy

Background: Homoeopathic medicines are used extensively for the treatment of many human diseases and are shown to affect immune cell functions. However, our understanding of the immunomodulatory effects of such medicines and associated mechanisms of action remains limited. Objectives: The present study aims to investigate the immunomodulatory effects of Arsenic album, Rhus toxicodendron, Hepar sulphuris and Bryonia alba on lipopolysaccharide (LPS) induced peripheral blood neutrophils and monocytes. Materials and Methods: In this work, neutrophils and monocytes were treated with different homoeopathic dilutions of 30C potency separately, followed by stimulation with the LPS, to examine the immunomodulatory effects of these …

A Scientific Convention On World Homoeopathy Day: ‘Homoeoparivar – Sarvajan Swasthya, One Health One Family’ – A Conference Report, Babita Rani Kondle, Divya Taneja, Subhash Kaushik

Indian Journal of Research in Homoeopathy

The Central Council for Research in Homoeopathy organised a scientific convention on World Homoeopathy Day on April 10th, 2023, at Vigyan Bhavan, New Delhi, to commemorate the 268th birth anniversary of Dr. Christian Friedrich Samuel Hahnemann. The conference’s theme was ‘Sarvajan Swasthya Homoeoparivar – One Health, One Family’. The convention’s aim was to come together in this profession as a Family/Parivar to collate the experiences of policymakers, researchers and practitioners to create a harmonious growth of Homoeopathy and to achieve the potential that Homoeopathy reaches each household of the country as the first line of treatment.

Research Highlights, Arti Goyal, Anamika Singh

Indian Journal of Research in Homoeopathy

Research Highlights

Identification Of Tectorigenin As A Natural Pro-Hypoxia Compound: Implications In Modulation Of Cellular Differentiation And Senescence, Mallika Khurana, Renu Wadhwa, Sunil Kaul

Research Symposium

Background: Hypoxia, a suboptimal level of oxygen, evokes stress response in cells and activated hypoxia signaling has been largely established as a pro-metastasis and pro-angiogenic factor for tumor cells. On the other hand, age-related neurodegenerative disorders are characterized by hypoxic environment, accumulation of molecular garbage and induction of premature senescence. Several recent studies have reported anti-stress impact of the intermittent induction of hypoxia signaling in these cells.

Methods: Screening of a phytochemical library using Hypoxia Responsive Element (HRE) driven luciferase as a reporter was carried out to identify hypoxia-modulating phytochemicals. Activation of HIF-1a (master regulator of hypoxia signaling) was validated …

Anti-Inflammatory And Antioxidant Effects Of Sea Urchin Spine Extract, Dina Magdy El Gamal

The Undergraduate Research Journal

Diadema savignyi spine extract in an experimental setup using L929 cell line in vitro. The cell metabolic activity of L929 cells is tested through an MTT assay. The sea urchin spine extract is applied to the cells in two concentrations: 100 μg/ml (136% viability) and 200 μg/ml (95% viability). The bioactive components of the sea urchin spine are identified via GC-MS, and the antioxidant and anti-inflammatory activities are evaluated using catalase assay (CAT), glutathione (GSH), and nitric oxide (NO) tests. Results show that the GC-MS identified bioactive components including the anti-inflammatory and anti-irritant bisabolol oxide and the pro-inflammatory oleic acid. …

Nutritional Profile And Health Benefits Of Stevia Rebaudiana Bertoni: An Updated Review, Ishrat Fatima, Mubashrah Munir, Sehrish Sadia, Akash Tariq, Rahmatullah Qureshi

Journal of Bioresource Management

Aim of this comprehensive review is to document the up-dated data about pharmaceutical potential of Stevia rebaudiana Bertoni with special focus on its antioxidant activity. A total of 184 research articles were reviewed and five research engines were used to collect the data. The S. rebaudiana (Asteraceae) is indigenous to South America, now cultivated in many countries worldwide to be used as a natural bio-sweetener. Various nutritionally and medically important bioactive compounds such as diterpene glycosides, fatty acids, alkaloids, tannins, saponins, anthraquinones, phenolics, flavonoids, carbohydrates, carotenoids, steroids, polysaccharides and other phytochemicals constitute chemical composition of Stevia. Owing to the …

My Happy Baby Is Back: Zero Balancing, Craniosacral Therapy And A Baby’S Journey To Becoming Mobile, Veronica Quarry

Journal of Transformative Touch

Alison began receiving ZB and CST at 13 months of age due to gross motor delays: at that age she was only able to sit somewhat rigidly. After the first session, Alison changed` from being very unhappy and seemingly frustrated to being happy and more calm. Within one month of weekly sessions, Alison was able to be on her tummy, began to crawl, became more agile in seated play, was squatting and standing and took her first steps.

The Efficacy Of Group-Based Acceptance And Commitment Therapy For Decreasing Post-Stroke Depression To Improve Functional Outcomes, Lindsay Marie Folsom

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.