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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Using Meditation To Improve Measures Of Attention In Older Adults, Sabrina Ford
Using Meditation To Improve Measures Of Attention In Older Adults, Sabrina Ford
Electronic Thesis and Dissertation Repository
Age-related cognitive decline greatly impacts quality of life for older adults. Previous research has indicated that meditation may act as a neuroprotective factor to prevent age-related cognitive decline. This thesis sought to replicate previous findings and investigate if a four-week meditation intervention would improve sustained attention. Participants 60 years and older (n=27, 17 female) were recruited and assigned to a focused-attention (FA) meditation or relaxation group which met for four weeks, three times a week. Resting-state EEG was used to collect individual alpha peak frequency (iAPF) and frontal alpha asymmetry (FAA). The Sustained Attention to Response Task (SART) was also …
Identification Of Human Postnatal Progenitor Cells With Multifaceted Regenerative Functions, Tyler T. Cooper
Identification Of Human Postnatal Progenitor Cells With Multifaceted Regenerative Functions, Tyler T. Cooper
Electronic Thesis and Dissertation Repository
Regenerative medicine is a multidisciplinary effort to regenerate or replace a deficiency of functional cells/tissues, such as deteriorated vasculature in cardiovascular pathologies or depleted -cell mass in diabetes. The transplantation of pro-regenerative progenitor cell populations has demonstrated therapeutic benefits in pre-clinical models, although translation to clinical efficacy is limited by the paradoxical balance between cell expansion ex vivo and loss of regenerative functions in vivo. Herein, this thesis encompasses two distinct approaches to circumvent translational deficiencies; 1) prevention of hematopoietic progenitor cell differentiation during ex vivo expansion and 2) utilizing the secretome of pancreas-derived multipotent stromal cell as a …
Effects Of Niacin And Vitamin D On Endothelial Cell Angiogenic Function And Vascular Regeneration During Lipotoxicity, Kia Mae Peters
Effects Of Niacin And Vitamin D On Endothelial Cell Angiogenic Function And Vascular Regeneration During Lipotoxicity, Kia Mae Peters
Electronic Thesis and Dissertation Repository
Observational studies have suggested an association between low levels of niacin and vitamin D and increased cardiovascular disease risk. Both vitamins have been shown to improve endothelial functions and vascular regeneration following vascular injury, however, it appears vitamin D may promote or inhibit neovascularization in a context-dependent manner. We hypothesized that supplementation of vitamin D alone and in combination with niacin, would improve endothelial cell function under lipotoxic conditions and promote revascularization and functional recovery in obese mice with ischemic injury. Matrigel assays, mRNA microarray analyses and growth rate assays were used to investigate angiogenic function of endothelial cells exposed …