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Full-Text Articles in Plant Sciences
Functional Characterization Of The Aspergillus Fumigatus Calcineurin, Márcia Eliana Da Silva Ferreira, Thorsten Heinekamp, Albert Hartl, Axel A. Brakhage, Camile P. Semighini, Steven D. Harris, Marcela Savoldi, Paula Fagundes De Gouvêa, Maria Helena De Souza Goldman, Gustavo H. Goldman
Functional Characterization Of The Aspergillus Fumigatus Calcineurin, Márcia Eliana Da Silva Ferreira, Thorsten Heinekamp, Albert Hartl, Axel A. Brakhage, Camile P. Semighini, Steven D. Harris, Marcela Savoldi, Paula Fagundes De Gouvêa, Maria Helena De Souza Goldman, Gustavo H. Goldman
Department of Plant Pathology: Faculty Publications
Aspergillus fumigatus is an aggressive opportunistic pathogen of humans as well as a major allergen. Environmental sensing and retrieving essential nutrients from the environment are general metabolic traits associated with the growth of this saprophytic fungus. Two important mediators of calcium signals in eukaryotic cells are the Ca2+-binding protein calmodulin and the Ca2+/calmodulin-dependent phosphatase calcineurin. Calcineurin is a heterodimer that consists of a catalytic subunit A and a Ca2+/calmodulin binding unit. We deleted the A. fumigatus calA gene, which encodes the calcineurin A catalytic subunit, and demonstrated that this gene is not essential in …