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Effects Of Age On Induced Glaucoma In An In Vivo Rat Model, Robert Cox
Effects Of Age On Induced Glaucoma In An In Vivo Rat Model, Robert Cox
Honors Theses
Previous in vitro studies from this lab have demonstrated that injection of a hypertonic saline solution into the episcleral vein of the rat’s eye mimics the effect of glaucoma. However, the age of the rat related to the amount of cell loss in the retina ganglion cell (RGC) layer is unknown. To address this issue, we propose to analyze the correlation of age and cell loss between 3-6 month and 1-year-old Long Evan rats. When inducing glaucoma in the Long Evan rats, the left eye in each rat was left untreated and used as an internal control. In the right …
Intraocular Pressure Measurements In A Rat Glaucoma Model, Michael Doyle
Intraocular Pressure Measurements In A Rat Glaucoma Model, Michael Doyle
Honors Theses
The main objective of this study was to determine if consistent intraocular pressure (IOP) measurements could be obtained from an in vivo Long Evans rat glaucoma model. An increase in IOP is the primary risk factor associated with glaucoma and reliable IOP measurements would validate our in vivo glaucoma model that we are inducing in rats. The study used nine Long Evans rats. Three rats severed as controls, three received surgery to induce glaucoma and three were administered PNU-282987 neuroprotective eye drops and then surgery to induce glaucoma. IOP measurements were obtained by tapping the retina of the rat eye …