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Full-Text Articles in Other Life Sciences
A Glutathione-Independent Glyoxalase Of The Dj-1 Superfamily Plays An Important Role In Managing Metabolically Generated Methylglyoxal In Candida Albicans, Sahar Hasim, Nur Ahmad Hussin, Fadhel Alomar, Keshore R. Bidasee, Kenneth W. Nickerson, Mark A. Wilson
A Glutathione-Independent Glyoxalase Of The Dj-1 Superfamily Plays An Important Role In Managing Metabolically Generated Methylglyoxal In Candida Albicans, Sahar Hasim, Nur Ahmad Hussin, Fadhel Alomar, Keshore R. Bidasee, Kenneth W. Nickerson, Mark A. Wilson
Kenneth Nickerson Papers
Methylglyoxal is a cytotoxic reactive carbonyl compound produced by central metabolism. Dedicated glyoxalases convert methylglyoxal to D-lactate using multiple catalytic strategies. In this study, the DJ-1 superfamily member ORF 19.251/GLX3 from Candida albicans is shown to possess glyoxalase activity, making this the first demonstrated glutathione-independent glyoxalase in fungi. The crystal structure of Glx3p indicates that the protein is a monomer containing the catalytic triad Cys136- His137-Glu168. Purified Glx3p has an in vitro methylglyoxalase activity (Km = 5.5 mM andkcat = 7.8 s-1) that is significantly greater than that of …
Land Use And Climate Variability Amplify Carbon, Nutrient, And Contaminant Pulses: A Review With Management Implications, Sujay S. Kaushal, Peter M. Mayer, Philippe G. Vidon, Rose M. Smith, Micheal J. Pennino, Tamara A. Newcomer, Shuiwang Duan, Claire Welty, Kenneth T. Belt
Land Use And Climate Variability Amplify Carbon, Nutrient, And Contaminant Pulses: A Review With Management Implications, Sujay S. Kaushal, Peter M. Mayer, Philippe G. Vidon, Rose M. Smith, Micheal J. Pennino, Tamara A. Newcomer, Shuiwang Duan, Claire Welty, Kenneth T. Belt
United States Environmental Protection Agency: Staff Publications
Nonpoint source pollution from agriculture and urbanization is increasing globally at the same time climate extremes have increased in frequency and intensity. We review >200 studies of hydrologic and gaseous fluxes and show how the interaction between land use and climate variability alters magnitude and frequency of carbon, nutrient, and greenhouse gas pulses in watersheds. Agricultural and urban watersheds respond similarly to climate variability due to headwater alteration and loss of ecosystem services to buffer runoff and temperature changes. Organic carbon concentrations/exports increase and organic carbon quality changes with runoff. Nitrogen and phosphorus exports increase during floods (sometimes by an …