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High-Density Lipoprotein Metabolism In Human Apolipoprotein B100 Transgenic/Brown Adipose Tissue Deficient Mice: A Model Of Obesity-Induced Hyperinsulinemia, Sarah J. Ehlers, Stephanie M. Larson, Heather E. Rasmussen, Young-Ki Park, Ji-Young Lee
High-Density Lipoprotein Metabolism In Human Apolipoprotein B100 Transgenic/Brown Adipose Tissue Deficient Mice: A Model Of Obesity-Induced Hyperinsulinemia, Sarah J. Ehlers, Stephanie M. Larson, Heather E. Rasmussen, Young-Ki Park, Ji-Young Lee
Department of Nutrition and Health Sciences: Faculty Publications
Obese and diabetic humans display decreased plasma high-density lipoprotein cholesterol (HDL-C) concentrations and an increased risk for coronary heart disease. However, investigation on HDL metabolism in obesity with a particular emphasis on hepatic ATP-binding cassette transporter A1 (ABCA1), the primary factor for HDL formation, has not been well studied. Human apolipoprotein B100 transgenic (hApoBtg) and brown adipose tissue deficient (BATless) mice were crossed to generate hApoBtg/BATless mice. Male and female hApoBtg and hApoBtg/BATless mice were maintained on either a regular rodent chow diet or a diet high …