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Programming Heart Disease: Does Poor Maternal Nutrition Alter Expression Of Cardiac Markers Of Proliferation, Hypertrophy, And Fibrosis In Offspring?, Cathy Chun May 2016

Programming Heart Disease: Does Poor Maternal Nutrition Alter Expression Of Cardiac Markers Of Proliferation, Hypertrophy, And Fibrosis In Offspring?, Cathy Chun

Honors Scholar Theses

Maternal malnutrition can affect fetal organogenesis, metabolic processes, and factors involved in developmental regulation. Of the many physiological effects poor maternal nutrition can induce in offspring, one of the most important organs affected is the heart. Cardiovascular disease has been associated with poor maternal diet. It also been suggested that hypertension can originate during impaired intrauterine growth and development. Hypertension can trigger hypertensive heart disease and is associated with numerous heart complications. We hypothesized that poor maternal nutrition would alter critical growth factors associated with normal heart development, specifically, insulin-like growth factor (IGF)-1, IGF-2, transforming growth factor (TGF)β, and connective …


How The U.S. Low-Fat Diet Recommendations Of 1977 Contributed To The Declining Health Of Americans, Julia Reedy Apr 2016

How The U.S. Low-Fat Diet Recommendations Of 1977 Contributed To The Declining Health Of Americans, Julia Reedy

Honors Scholar Theses

In 1977, the first edition of The Dietary Goals for the United States (“The Recommendations”) was published in attempts to reduce incidence of diet-related diseases such as cardiovascular disease and diabetes. While numerous dietary adjustments were recommended in order to improve health, fat was identified as the most instrumental factor. However there exist many confounders of The Recommendations, including Medium Chain Triglycerides (MCT), fat from dairy products, eggs and the high-fat Mediterranean Diet. Nonetheless, the food industry made adjustments to acclimate to the anti-fat mentality The Recommendations initiated. Linoleic acid- (LA) rich soybean oil became heavily used, drastically altering the …