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Reduction In Cholesterol Absorption Is Enhanced By Stearate-Enriched Plant Sterol Esters In Hamsters, Heather E. Rasmussen, David M. Guderian Jr., Curtis A. Wray, Patrick H. Dussault, Vicki L. Schlegel, Timothy P. Carr
Reduction In Cholesterol Absorption Is Enhanced By Stearate-Enriched Plant Sterol Esters In Hamsters, Heather E. Rasmussen, David M. Guderian Jr., Curtis A. Wray, Patrick H. Dussault, Vicki L. Schlegel, Timothy P. Carr
Department of Nutrition and Health Sciences: Faculty Publications
Consumption of plant sterol esters reduces plasma LDL cholesterol concentration by inhibiting intestinal cholesterol absorption. Commercially available plant sterol esters are prepared by esterifying free sterols to fatty acids from edible plant oils such as canola, soybean, and sunflower. To determine the influence of the fatty acid moiety on cholesterol metabolism, plant sterol esters were made with fatty acids from soybean oil (SO), beef tallow (BT), or purified stearic acid (SA) and fed to male hamsters for 4 wk. A control group fed no plant sterol esters was also included. Hamsters fed BT and SA had significantly lower cholesterol absorption …
Renal Damage In Experimentally-Induced Cirrhosis In Rats: Role Of Oxygen Free Radicals, Sathish Kumar Natarajan, Jayasree Basivireddy, Anup Ramachandran, Simmy Thomas, Prabhu Ramamoorthy, Anna B. Pulimood, Molly Jacob, Kunissery A. Balasubramanian
Renal Damage In Experimentally-Induced Cirrhosis In Rats: Role Of Oxygen Free Radicals, Sathish Kumar Natarajan, Jayasree Basivireddy, Anup Ramachandran, Simmy Thomas, Prabhu Ramamoorthy, Anna B. Pulimood, Molly Jacob, Kunissery A. Balasubramanian
Department of Nutrition and Health Sciences: Faculty Publications
Cirrhosis with ascites is associated with impaired renal function accompanied by sodium and water retention. Although it has been suggested that mediators such as nitric oxide play a role in the development of renal failure in this situation, other mechanisms underlying the process are not well understood. This study examined the role of oxidative stress in mediating renal damage during the development of cirrhosis in order to understand mechanisms involved in the process. It was shown that carbon tetrachloride– or thioacetamide-induced cirrhosis in rats results in oxidative stress in the kidney as seen by increased lipid peroxidation and protein oxidation, …
Intestinal Mucosal Alterations In Rats With Carbon Tetrachloride-Induced Cirrhosis: Changes In Glycosylation And Luminal Bacteria, Sathish Kumar Natarajan, Prabhu Ramamoorthy, Simmy Thomas, Jayasree Basivireddy, Gagandeep Kang, Anup Ramachandran, Anna B. Pulimood, K. A. Balasubramanian
Intestinal Mucosal Alterations In Rats With Carbon Tetrachloride-Induced Cirrhosis: Changes In Glycosylation And Luminal Bacteria, Sathish Kumar Natarajan, Prabhu Ramamoorthy, Simmy Thomas, Jayasree Basivireddy, Gagandeep Kang, Anup Ramachandran, Anna B. Pulimood, K. A. Balasubramanian
Department of Nutrition and Health Sciences: Faculty Publications
Spontaneous bacterial peritonitis is a major cause of mortality after liver cirrhosis. Altered permeability of the mucosa and deficiencies in host immune defenses through bacterial translocation from the intestine due to intestinal bacterial overgrowth have been implicated in the development of this complication. Molecular mechanisms underlying the process are not well known. In order to understand mechanisms involved in translocation of bacteria, this study explored the role of oxidative stress in mediating changes in intestinal mucosal glycosylation and luminal bacterial content during cirrhosis. CCl4-induced cirrhosis in rats led to prolonged oxidative stress in the intestine, accompanied by increased …