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Estradiol’S Role In Timely Puberty Onset In The Ewe, Eliana Gerardine Aerts
Estradiol’S Role In Timely Puberty Onset In The Ewe, Eliana Gerardine Aerts
Graduate Theses, Dissertations, and Problem Reports
In female sheep, the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus triggers luteinizing hormone (LH) to be released from the pituitary. Luteinizing hormone, in turn, acts on the ovaries to elicit estradiol (E2) release. E2 acts in a negative feedback manner to control the amount of LH released. The increase in LH release that drives puberty onset results from a decrease in sensitivity to E2 as the animal ages. However, the neural mechanisms mediating this change in sensitivity are not known, as is where in the hypothalamus E2-negative feedback occurs. In the arcuate …