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Epigenetic Modification Of Vitamin D-Induced Gene Expression In Human Colorectal And Breast Cancer Cell Lines, Sharmin Hossain

Doctoral Dissertations

Epigenetics is the study of the regulation of genes that is not dependent on nucleotide sequence. This may include heritable changes in gene activity and expression but also those that are not heritable. In recent years, epigenetic researchers have made great strides in understanding the molecular mechanisms behind cellular functions in response to diet, exercise, and other lifestyle modifications, like methylation, histone modification etc. It is now known that the epigenome is critical to healthy human development in addition to genetics, and dietary factors can modulate epigenetic alterations in cells. The classic view of cancer etiology is that genetic alterations …