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The Efficacy Of Curcumin And Oil Palm Phenolics, As Potential Antidepressants, On The Serotonin Pathway In A Neuronal Rat Cell Line, Melanie Hutchings

Wayne State University Theses

Depression can be experienced by individuals of all ages, and can result in alterations of mood, decreased ability to function, and fatigue. Current treatment involves pharmaceuticals, which can result in adverse side effects, and there is a risk of relapse. Nutraceuticals are of interest because they may be able to work as efficiently as current treatments, and will cause fewer adverse effects. Curcumin and oil palm phenolics (OPP) are polyphenolic compounds that exhibit beneficial properties, including anti-oxidant and anti-cancer, and may assist in the regulation of diabetes. For this experiment, we utilized a neuronal rat cell line, RN46A-B14, which exhibits …