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Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model, Nadia Saadat
Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model, Nadia Saadat
Wayne State University Dissertations
Adenocarcinoma of pancreas is recognized for its poor prognosis, as it progresses asymptomatically and is rarely diagnosed at early stage. According to American cancer society pancreatic cancer, it has lowest survival rate in all cancer types, with less than 6% five year survival rate. Surgical resection is only possible for 20% of diagnosed cases and current chemotherapy has only 15% response rate. Even the most favored drug, Gemcitabine, increases survival time only by a few months, depending on the stage at diagnosis. Some bioactive food components or nutraceuticals have shown chemopreventive and chemotherapeutic effects without added side effects. Garcinol is …
The Effect Of Proalgazyme And Its Subfractions On Lipid Metabolism In Diet Induced Hypercholesterolemic Hamsters: Correlation With Plasma Metabolomic Profile, Andreea Geamanu
Wayne State University Dissertations
ABSTRACT
THE EFFECT OF PROALGAZYME AND ITS SUBFRACTIONS ON LIPID METABOLISM IN DIET INDUCED HYPERCHOLESTEROLEMIC HAMSTRES:
CORREALTION WITH PLASMA METABOLOMIC PROFILE
by
ANDREEA GEAMANU
December 2013
Advisor: Dr. Smiti Gupta
Major: Nutrition and Food Science
Degree: Doctor of Philosophy
Background: Plasma HDL cholesterol levels are inversely related to cardiovascular disease, which is the leading cause of death worldwide. This study investigated the preventative effect of an algae infusion, ProAlgaZyme (PAZ) and its subfractions (F1, F2, F3, F4) on plasma HDL in a hamster model. Further, the study aimed to identify the biologically active fraction of PAZ and to determine the …