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The Relationship Between Excessive Folic Acid Intake And Genome Instability In Human Lymphocytes, Khadijah Ibrahim Alnabbat
The Relationship Between Excessive Folic Acid Intake And Genome Instability In Human Lymphocytes, Khadijah Ibrahim Alnabbat
Wayne State University Dissertations
Since its synthesis in 1945, Folic acid (FA) is widely used as a supplement/additive to our food due to its stability and high bioavailability. FA is proposed to alleviate anemia and reduce neural tube defects (NTD). As a provitamin, FA is activated through a two-step reaction catalyzed by dihydrofolate reductase (DHFR) in the folate metabolism pathway. FA activation rate is found to be slow in humans. After the implementation of mandatory food fortification program of grain and grain products with folic acid in the USA in 1998, many concerns have been raised about the unintended deleterious consequence of exposing the …