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Very Low-Carbohydrate, High-Fat, Weight Reduction Diet Decreases Hepatic Gene Response To Glucose In Obese Rats, Kathleen V. Axen, Marianna A. Harper, Yu Fu Kuo, Kenneth Axen
Very Low-Carbohydrate, High-Fat, Weight Reduction Diet Decreases Hepatic Gene Response To Glucose In Obese Rats, Kathleen V. Axen, Marianna A. Harper, Yu Fu Kuo, Kenneth Axen
Publications and Research
Background: Very low carbohydrate (VLC) diets are used to promote weight loss and improve insulin resistance (IR) in obesity. Since the high fat content of VLC diets may predispose to hepatic steatosis and hepatic insulin resistance, we investigated the effect of a VLC weight-reduction diet on measures of hepatic and whole body insulin resistance in obese rats.
Methods: In Phase 1, adult male Sprague-Dawley rats were made obese by ad libitum consumption of a high-fat (HF1, 60% of energy) diet; control rats ate a lower-fat (LF, 15%) diet for 10 weeks. In Phase 2, obese rats were fed energy-restricted amounts …