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Loss Of Function Mutation In Toll-Like Receptor-4 Does Not Offer Protection Against Obesity And Insulin Resistance Induced By A Diet High In Trans Fat In Mice, Matam Vijay-Kumar, Jesse D. Aitken, Frederic A. Carvalho, Thomas R. Ziegler, Andrew T. Gewirtz, Vijay Ganji
Loss Of Function Mutation In Toll-Like Receptor-4 Does Not Offer Protection Against Obesity And Insulin Resistance Induced By A Diet High In Trans Fat In Mice, Matam Vijay-Kumar, Jesse D. Aitken, Frederic A. Carvalho, Thomas R. Ziegler, Andrew T. Gewirtz, Vijay Ganji
Nutrition Faculty Publications
Background: Toll-like receptor-4 (TLR4) triggers inflammatory signaling in response to microbial lipoploysaccharide. It has been reported that loss of TLR4 protected against saturated fat-induced inflammation and insulin resistance. It is not known whether loss of TLR4 function offers protection against trans fat (TF) induced obesity, inflammation, and insulin resistance. We investigated whether mice with loss of function mutation in TLR4 were resistant to TF-induced pathologies such as obesity, inflammation, hyperglycemia, and hyperinsulinemia.
Methods: C57BL/6j and C57BL/10 mice were cross bred to generate TLR4 mutant and wild type (WT). TLR4 mutant (n = 12) and WT (n = 12) mice were …