Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Nutrition
Fish Oil Rich Diet In Comparison To Saturated Fat Rich Diet Offered Protection Against Lipopolysaccharide-Induced Inflammation And Insulin Resistance In Mice, Matam Vijay-Kumar, Sally M. Vanegas, Nilam Patel, Jesse D. Aitken, Thomas R. Ziegler, Vijay Ganji
Fish Oil Rich Diet In Comparison To Saturated Fat Rich Diet Offered Protection Against Lipopolysaccharide-Induced Inflammation And Insulin Resistance In Mice, Matam Vijay-Kumar, Sally M. Vanegas, Nilam Patel, Jesse D. Aitken, Thomas R. Ziegler, Vijay Ganji
Nutrition Faculty Publications
Background and Objective: Systemic chronic inflammation is linked to metabolic syndrome, type-2 diabetes, and heart disease. Lipopolysaccharide (LPS), a Gram negative microbial product, triggers inflammation through toll-like-receptor-4 (TLR-4) signaling. It has been reported that dietary fatty acids also modulate inflammation through TLR-4. We investigated whether fish oil (FO) rich diet in comparison to saturated fat (SF) rich diet would confer protection from pathologies induced by LPS.
Methods: Twenty C57BL/6 mice were divided into two groups. One group received FO-diet and other received SF-diet ad libitum for 60 days. Diets were isocaloric containing 45% energy from fat. After 60-days of feeding, …
Loss Of Function Mutation In Toll-Like Receptor-4 Does Not Offer Protection Against Obesity And Insulin Resistance Induced By A Diet High In Trans Fat In Mice, Matam Vijay-Kumar, Jesse D. Aitken, Frederic A. Carvalho, Thomas R. Ziegler, Andrew T. Gewirtz, Vijay Ganji
Loss Of Function Mutation In Toll-Like Receptor-4 Does Not Offer Protection Against Obesity And Insulin Resistance Induced By A Diet High In Trans Fat In Mice, Matam Vijay-Kumar, Jesse D. Aitken, Frederic A. Carvalho, Thomas R. Ziegler, Andrew T. Gewirtz, Vijay Ganji
Nutrition Faculty Publications
Background: Toll-like receptor-4 (TLR4) triggers inflammatory signaling in response to microbial lipoploysaccharide. It has been reported that loss of TLR4 protected against saturated fat-induced inflammation and insulin resistance. It is not known whether loss of TLR4 function offers protection against trans fat (TF) induced obesity, inflammation, and insulin resistance. We investigated whether mice with loss of function mutation in TLR4 were resistant to TF-induced pathologies such as obesity, inflammation, hyperglycemia, and hyperinsulinemia.
Methods: C57BL/6j and C57BL/10 mice were cross bred to generate TLR4 mutant and wild type (WT). TLR4 mutant (n = 12) and WT (n = 12) mice were …