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The Impact Of Insulin Dysregulation On Protein Metabolism In Horses, Caroline Margot Marcelle Loos
The Impact Of Insulin Dysregulation On Protein Metabolism In Horses, Caroline Margot Marcelle Loos
Theses and Dissertations--Animal and Food Sciences
Insulin plays a vital role in whole-body metabolism and provides a major anabolic stimulus for cellular signaling pathways, including those involved in the metabolism of glucose and protein. Consequently, insulin dysregulation (ID) is known to alter molecular signal transduction in insulin-sensitive tissues such as skeletal muscle, thereby disrupting glucose metabolism and compromising protein synthetic capacity. Our first objective was to induce ID in healthy horses by administering dexamethasone (DEX), a potent glucocorticoid, for 21 days. We evaluated the effects on insulin-stimulated muscle protein signaling components involved in the mammalian target of rapamycin (mTOR) pathway. DEX-induced ID reduced insulin-stimulated activation of …
Applications In Utilization Of Forage Chemical Composition And Predicting Equine Digestibility, Veronica Taylor Bill
Applications In Utilization Of Forage Chemical Composition And Predicting Equine Digestibility, Veronica Taylor Bill
Theses and Dissertations--Animal and Food Sciences
Most forage quality models were developed for ruminant nutrition, and may not apply to the horse. This two-part study evaluated the relationship between forage chemical composition and dry matter digestibility (DMD) using an in vitro method with equine feces as the inoculums. The first experiment determined that compared to 48 h of incubation, 72 h of incubation resulted in higher DMD for some forages. As a result of experiment 1, incubations in experiment 2 were conducted using 48 and 72 h incubation periods at 38 degrees C. The second experiment evaluated the effect of chemical composition on DMD. Thirty-one hay …