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Dietary Calcium Induced Cytological And Biochemical Changes In Thyroid, Amar K. Chandra, Haimanti Goswami, Pallav Sengupta
Dietary Calcium Induced Cytological And Biochemical Changes In Thyroid, Amar K. Chandra, Haimanti Goswami, Pallav Sengupta
Pallav Sengupta, PhD
Certain epidemiological studies revealed correlation between hard water consumption (with high calcium) and thyroid size of the population, though the possible alterations in thyroid physiology upon calcium exposure are still inconclusive. Adult male Wistar strain rats were subjected to calcium treatment at the doses of 0.5g%, 1.0g% and 1.5g% calcium chloride (CaCl2) for 60 days. The parameters studied were -thyroid gland weight, histopathology, histomorphometry; thyroid peroxidase (TPO), 5'- deiodinase I (DI), sodium-potassium adenosine triphosphatase (Na+-K+-ATPase) activities; serum total and free thyroxine (tT4, fT4), total and free triiodothyronine (tT3, fT3), thyroid stimulating hormone (TSH) levels. Enlargement of thyroid with hypertrophic and …