Laboratory and Basic Science Research Commons^™

Nutrition Derived Advanced Glycation End Products Are Bio-Social Determinants Of Health That Inform On Cancer Disparities, David P. Turner, Victoria J. Findlay, Bradley A. Krisanits

Surgery Presentations

Objectives

Through their ability to perpetuate a reactive stroma, the objective was to define the increased nutritional bioavailability of advanced glycation end products (AGEs) as a pro-tumorigenic consequence of interrelated health inequity risk factors that can influence ancestry specific tumor biology.

Methods

In vivo, ex vivo, and in vitro models were used to define the molecular effects of nutrition associated AGEs on the ancestry specific tumor microenvironment and tumor growth.

Results

The PI’s work provides the first in vivo evidence supporting an oncogenic role for AGEs. In mouse allograft models, both the chronic consumption of AGEs and pre-treatment …