Open Access. Powered by Scholars. Published by Universities.®
Laboratory and Basic Science Research Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Animal Experimentation and Research (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Engineering (1)
- Biomechanics and Biotransport (1)
- Biomedical Engineering and Bioengineering (1)
-
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Cellular and Molecular Physiology (1)
- Chemicals and Drugs (1)
- Developmental Neuroscience (1)
- Disease Modeling (1)
- Diseases (1)
- Engineering (1)
- Immunology and Infectious Disease (1)
- Immunotherapy (1)
- Lipids (1)
- Medicine and Health Sciences (1)
- Molecular Biology (1)
- Molecular and Cellular Neuroscience (1)
- Molecular, Cellular, and Tissue Engineering (1)
- Neuroscience and Neurobiology (1)
- Other Biomedical Engineering and Bioengineering (1)
- Pathological Conditions, Signs and Symptoms (1)
- Pharmaceutical Preparations (1)
- Physiology (1)
- Research Methods in Life Sciences (1)
- Respiratory Tract Diseases (1)
Articles 1 - 2 of 2
Full-Text Articles in Laboratory and Basic Science Research
Focal Augmentation Of Somatostatin Interneuron Function And Subsequent Circuit Effects In Developmentally Malformed, Epileptogenic Cortex, Nicole Ekanem
Theses and Dissertations
Drug-resistant epilepsy (DRE) is a common clinical sequela of developmental cortical malformations such as polymicrogyria. Unfortunately, much remains unknown about the aberrant GABA-mediated circuit alterations that underlie DRE's onset and persistence in this context. To address this knowledge gap, we utilized the transcranial freeze lesion model in optogenetic mice lines (Somatostatin (SST)-Cre or Parvalbumin (PV)-Cre x floxed channelrhodopsin-2) to dissect features of the SST, PV, and pyramidal neuron microcircuit that are potentially associated with DRE. Investigations took place within developmental microgyria’s known pathological substrate, the adjoined and epileptogenic paramicrogyral region (PMR). As well, microcircuit relationships within the previously unexplored range …
The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine
The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine
Theses and Dissertations
Patients with severe lung pathologies, such as Acute Respiratory Distress Syndrome (ARDS), often require mechanical ventilation as a clinical intervention; however, this procedure frequently exacerbates the original pulmonary issue and produces an exaggerated inflammatory response that potentially leads to sepsis, multisystem organ failure, and mortality. This acute lung injury (ALI) condition has been termed Ventilator-Induced Lung Injury (VILI). Alveolar overdistension, cyclic atelectasis, and biotrauma are the primary injury mechanisms in VILI that lead to the loss of alveolar barrier integrity and pulmonary inflammation. Stress and strains during mechanical ventilation are believed to initiate alveolar epithelial mechanotransduction signaling mechanisms that contribute …