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Full-Text Articles in Laboratory and Basic Science Research
Nutrition Derived Advanced Glycation End Products Are Bio-Social Determinants Of Health That Inform On Cancer Disparities, David P. Turner, Victoria J. Findlay, Bradley A. Krisanits
Nutrition Derived Advanced Glycation End Products Are Bio-Social Determinants Of Health That Inform On Cancer Disparities, David P. Turner, Victoria J. Findlay, Bradley A. Krisanits
Surgery Presentations
Objectives
Through their ability to perpetuate a reactive stroma, the objective was to define the increased nutritional bioavailability of advanced glycation end products (AGEs) as a pro-tumorigenic consequence of interrelated health inequity risk factors that can influence ancestry specific tumor biology.
Methods
In vivo, ex vivo, and in vitro models were used to define the molecular effects of nutrition associated AGEs on the ancestry specific tumor microenvironment and tumor growth.
Results
The PI’s work provides the first in vivo evidence supporting an oncogenic role for AGEs. In mouse allograft models, both the chronic consumption of AGEs and pre-treatment …