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Full-Text Articles in Laboratory and Basic Science Research
Black Soldier Fly Larvae Manual, Haeree H. Park
Black Soldier Fly Larvae Manual, Haeree H. Park
Student Showcase
This manual is a resource for fisheries, hatcheries, and farms of all types that wish to exercise a sustainable management system utilizing black soldier fly larvae through the minimization of waste. Although black soldier fly larvae can be fed to small livestock such as chickens and rodents, this project and manual are tailored specifically to freshwater fish in hopes of closing the significant gap and inefficiencies of fish management and subsequent waste throughout the New England coastal area. There is an evident opportunity to harness black soldier fly larvae’s extraordinary bioconversion of organic matter that can lead to not only …
A Novel Population Of Natural Killer Cells Plays A Critical Role In The Depletion Of Splenic B2 B Cells During Experimental African Trypanosomiasis, Deborah Frenkel
A Novel Population Of Natural Killer Cells Plays A Critical Role In The Depletion Of Splenic B2 B Cells During Experimental African Trypanosomiasis, Deborah Frenkel
Doctoral Dissertations
Loss of humoral immune competence in T. brucei-infected mice is associated with the apoptotic depletion of splenic transitional, marginal zone and follicular B cells as well as a depletion of CD8+ T cells. This occurs rapidly after infection and impairs responses to vaccine antigens in addition to responses to newly arising VSG antigenic variants, leading to uncontrolled parasite growth and death of the infected mice. Infection-induced B2 B cell and CD8+ T cell loss requires the presence of a novel population of natural killer (NK) cells and is mediated by a perforin-dependent process consistent with perforin- and …
In Vivo Investigations Of Polymer Conjugates As Therapeutics, Elizabeth M. Henchey
In Vivo Investigations Of Polymer Conjugates As Therapeutics, Elizabeth M. Henchey
Masters Theses 1911 - February 2014
Polymer conjugates offer a way to introduce materials into the body that would normally be rejected or cause toxicity. Two polymers are investigated in vivo for uses in chemotherapeutic delivery, protein therapeutics, and DNA transfection. A novel polymer, polyMPC, has the ability to increase doxorubicin loading and its solubility, and is conjugated in a way to release its payload in a low pH environment. Through its conjugation, blood clearance time of doxorubicin is increased, and thus tumor exposure to the drug is increased with a single administration. It can be administered at ten times the concentration of free doxorubicin, and …