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Full-Text Articles in Biotechnology
Anti-Breast Cancer Effect Of Rhus Coriaria Extract, Khawlah Najib Athamneh
Anti-Breast Cancer Effect Of Rhus Coriaria Extract, Khawlah Najib Athamneh
Theses
Plants have been shown to be an excellent source of new drugs, including anticancer agents. Rhus coriaria, commonly known as sumac, a plant that is known to possess different therapeutic values including anti-oxidant and anti-microbial activities. Here, we investigated the anti-cancer effect of R. coriaria on triple negative MDA-MB-231 cell line. We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of MDA-MB-231 cell line in a time- and concentration dependent manner. RCE induced senescence and cell cycle arrest at G1 phase. Moreover, no proliferative recovery was detected after RCE removal. Annexin V staining and PARP cleavage analysis revealed …
Screening Of Synthetic Chemical Agents “Chromenes” With Potent Anti-Breast Cancer Activity, Aysha Hamad Zaher Saeed Al Meqbali
Screening Of Synthetic Chemical Agents “Chromenes” With Potent Anti-Breast Cancer Activity, Aysha Hamad Zaher Saeed Al Meqbali
Theses
Cancer is the second leading cause of death worldwide. Conventional therapies cause serious side effects and, at best, merely extend the patient’s lifespan by a few years. Cancer control may therefore benefit from the potential that resides in alternative therapies. There is thus an increasing demand to utilize alternative concepts or approaches to the prevention of cancer. The principal aim of this research is to screen and identify new synthetic compounds “chromenes”, with high efficiency, for breast cancer therapy. In this study, we have screened four newly designed and synthesized chromenes (C1, C15, C28 and C29) for their potential anticancer …