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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
White Matter Inflammation And Executive Dysfunction: Implications For Alzheimer Disease And Vascular Cognitive Impairment, Alexander Levit
White Matter Inflammation And Executive Dysfunction: Implications For Alzheimer Disease And Vascular Cognitive Impairment, Alexander Levit
Electronic Thesis and Dissertation Repository
White matter integrity is crucial to healthy executive function, the cognitive domain that enables functional independence. However, in the ageing brain, white matter is highly vulnerable. White matter inflammation increases with age and Alzheimer disease (AD), which disrupts the normal function of white matter. This may contribute to executive dysfunction, but the relationship between white matter inflammation and executive function has not been directly evaluated in ageing nor AD. White matter is also particularly vulnerable to cerebrovascular disease, corresponding with the common presentation of executive dysfunction in vascular cognitive impairment (VCI). Thus, white matter may be an important substrate by …
Cannabinoid Transmission In The Basolateral Amygdala Modulates Prefrontal Cortex And Ventral Hippocampal Activity, Brian J. Pereira
Cannabinoid Transmission In The Basolateral Amygdala Modulates Prefrontal Cortex And Ventral Hippocampal Activity, Brian J. Pereira
Electronic Thesis and Dissertation Repository
The cannabinoid system is important for maintaining neuron-to-neuron communication within the mammalian brain. One of the most commonly used substances to alter the cannabinoid system is cannabis. Individuals who are exposed to cannabis report having dissociable effects; both positive and negative. High amounts of THC have been commonly associated with the negative effects of cannabis, whereas CBD can be used to counter these. Pre-clinical evidence suggests that the combination of the two compounds can produce a therapeutic benefit for individuals who are susceptible to the effects of THC. The present study investigates whether the combination of THC+CBD can prevent electrophysiological …
Characterizing The Cognitive And Emotional Effects Of Delta-9-Tetrahydrocannabinol In Distinct Hippocampal Sub-Regions, Dinat Khan
Electronic Thesis and Dissertation Repository
The objective of this study is to determine the potential differential effects of THC in the DH or VH sub-regions, as well as the upstream effects on PFC neuronal activity and oscillations. Rodents used for electrophysiology were infused with THC or vehicle in the DH or VH regions, combined with PFC recordings. Additionally, a battery of behavioural paradigms was performed. Deficits in short-term memory when THC was infused into both regions was observed, however working memory was impaired with VH infusions only. This could be due to THC-induced dysregulation in the PFC, as beta oscillations were significantly decreased selectively in …
Synaptic Correlates For Stress Sensitization, Julia Kj Sunstrum
Synaptic Correlates For Stress Sensitization, Julia Kj Sunstrum
Electronic Thesis and Dissertation Repository
The stress response is essential for survival, but it can be detrimental when persistently activated during chronic stress. Therefore, the magnitude of the stress response must be finely-tuned in order to be adaptive. Indeed, an animal’s stress response system normally undergoes habituation that decreases responses to a repeated, familiar stressor. Importantly, the same animal still responds normally, or even becomes sensitized, to an unfamiliar (novel) stressor. This indicates that chronic stress simultaneously induces two opposing types of plasticity, one that underlies habituated responses and another that drives sensitized responses. The activation of the hypothalamic-pituitary-adrenal (HPA) axis — a hallmark of …
Role Of Stip1 In Tdp-43 Mediated Toxicity And Proteinopathy In Neurodegenerative Disorders, Abdul Razzaq
Role Of Stip1 In Tdp-43 Mediated Toxicity And Proteinopathy In Neurodegenerative Disorders, Abdul Razzaq
Electronic Thesis and Dissertation Repository
A common hallmark of neurodegenerative disorders is the abnormal aggregation of misfolded proteins. Aggregates of phosphorylated TAR-DNA-binding protein-43 (TDP-43) are found in multiple neurodegenerative disorders. The molecular chaperones Hsp70 and Hsp90 have been shown to be key modulators of TDP-43 phosphorylation and expression, however the mechanisms behind how this interaction occur are unclear. Stress-Inducible PhosphoProtein 1 (STIP1) is a critical co-chaperone linking Hsp90 to Hsp70 to modulate chaperone client stability. In this study, we evaluated the potential role of STIP1 in TDP-43 stability and cellular toxicity. We demonstrated that STIP1 interacts with TDP-43 and the deletion of STIP1 leads to …
Psychotropic Effects Of Cannabis Components On The Mesolimbic Dopaminergic System, Christopher Norris
Psychotropic Effects Of Cannabis Components On The Mesolimbic Dopaminergic System, Christopher Norris
Electronic Thesis and Dissertation Repository
The two most abundant phytochemical compounds in cannabis are cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC). THC is the primary psychoactive component of cannabis and is a partial CB1 receptor (CB1R) agonist. THC is believed to be responsible for the motivational and dependence-producing effects of cannabis and causes psychotomimetic and affective processing disturbances. Conversely, CBD, is non-psychoactive, acts as a 5-HT1A receptor agonist, antagonizes CB1Rs, and possesses both anti-psychotic and anxiolytic properties. The neural substrate believed to be responsible for many of the effects of cannabis is the dopaminergic, mesolimbic reward pathway which is …