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Full-Text Articles in Life Sciences
Reduction In Activity By Noxious Chemical Stimulation Is Ameliorated By Immersion In Analgesic Drugs In Zebrafish, Javier Lopez-Luna, Qussay Al-Jubouri, Waleed Al-Nuaimy, Lynne U. Sneddon
Reduction In Activity By Noxious Chemical Stimulation Is Ameliorated By Immersion In Analgesic Drugs In Zebrafish, Javier Lopez-Luna, Qussay Al-Jubouri, Waleed Al-Nuaimy, Lynne U. Sneddon
Anesthesia and Analgesia Collection
Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to determine their efficacy to reduce these responses. This approach aimed to validate larval zebrafish as a reliable replacement for adults as well as providing a high-throughput means of analysing behavioural responses. Zebrafish at 5 days postfertilization were exposed to known noxious stimuli: acetic acid (0.01%, 0.1% and 0.25%) and citric acid (0.1%, 1% and 5%). The behavioural response of each …
The Potential For Sentience In Fishes, Jay R. Stauffer Jr.
The Potential For Sentience In Fishes, Jay R. Stauffer Jr.
Animal Sentience
Balcombe’s book is filled with information on the biology, behavior, and life history of fishes. I do not agree with all his premises. I am still somewhat perplexed about the discussion of whether fish feel pain; I am not sure whether the distinction between nociception and pain makes any difference. Overall, however, his treatment of the principles of both natural and sexual selection is comprehensive and accurate, and has greatly increased my knowledge and awareness of the biology, ethology, and potential for sentience in fishes. In summary, this work has exposed me to new ideas about how to examine fishes …
The “Precautionary Principle” – A Work In Progress, Shelley Adamo
The “Precautionary Principle” – A Work In Progress, Shelley Adamo
Animal Sentience
The target article by Birch illustrates the practical difficulties with the “Animal Sentience Precautionary Principle” (ASPP) while presenting potential solutions. However, the ASPP will be difficult to use without guidelines detailing how evidence of sentience should be assessed. Moreover, extrapolating conclusions found for a single species to all species within an Order is problematic. Finally, I recommend that Birch demonstrate his ASPP framework using a controversial test case to help show how it could be used in real-world situations.
Assessing Negative And Positive Evidence For Animal Pain, Robert W. Elwood
Assessing Negative And Positive Evidence For Animal Pain, Robert W. Elwood
Animal Sentience
Jonathan Birch suggests that we should take one well-conducted study that produces results consistent with the idea of pain as being sufficient to invoke the animal sentience precautionary principle. Here, I consider how to balance negative and positive results from such studies using examples from my own work. I also consider which criteria of pain might provide strong inference about pain and which may prove to be weaker.