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Full-Text Articles in Life Sciences
Use Of Pre-S Protein-Containing Hepatitis B Virus Surface Antigens And A Powerful Adjuvant To Develop An Immune Therapy For Chronic Hepatitis B Virus Infection, J S. Yum, B C. Ahn, H J. Jo, D Y. Kim, K H. Kim, H S. Kim, Y C. Sung, J Yoon, John D. Morrey, H M. Moon
Use Of Pre-S Protein-Containing Hepatitis B Virus Surface Antigens And A Powerful Adjuvant To Develop An Immune Therapy For Chronic Hepatitis B Virus Infection, J S. Yum, B C. Ahn, H J. Jo, D Y. Kim, K H. Kim, H S. Kim, Y C. Sung, J Yoon, John D. Morrey, H M. Moon
John D. Morrey
A hepatitis B virus (HBV) vaccine has been developed using a new adjuvant and HBV surface antigens produced from a CHO cell line. The purified HBV surface antigens are composed of L protein, M protein, and S protein in a mixture of 20- and 40-nm diameter particles and filamentous forms. This HBV surface antigen, formulated with L-pampo, a proprietary adjuvant, induced 10 times more antibody than the same antigen with alum and was capable of inducing strong immune responses in three different HBV transgenic mice. In spite of the presence of a large amount of HBV antigen in the blood, …
Evaluation Of Elevated Alanine Aminotransferase And Hepatitis B Virus Dna In Healthy Seronegative Blood Donors, Natasha Ali, Bushra Moiz, Tariq Moatter
Evaluation Of Elevated Alanine Aminotransferase And Hepatitis B Virus Dna In Healthy Seronegative Blood Donors, Natasha Ali, Bushra Moiz, Tariq Moatter
Department of Pathology and Laboratory Medicine
Background: Serum alanine transaminase (ALT) has been used as a surrogate marker for detection of hepatitis B and C in blood donors in Pakistan since 1985. Since the introduction of more sensitive assays the value of ALT became questionable but it was still used with subsequent wastage of blood units with raised ALT.
Finding: We conducted a study for a period of one year to evaluate the usefulness of ALT. During the study period, 25117 subjects donated blood. Eight hundred and seventy two donors (3.4%) were positive for one or more serological tests. ALT of all donors ranged from …