Life Sciences Commons^™

Approaches To Development Of A User-Friendly Community Based Arsenic/Iron Removal Unit In Bangladesh, Khondoker Mahabub Hassan, Farooque Ahmed, Faisal Hai, Saleh Faraj Magram

Faisal I Hai

The present stydy focuses on the strategies to modify the design of a community based Arsenic - Iron Removal Unit (AIRU) based on the field performance of the AIRU and the feedback from the users. The ultimate aim was to offer a user-friendly and sustainable system. Appropriate modifications in the design of the developed unit reduced the propensities of water head-loss and media clogging, thereby yielding sustained flow rate. Introduction of a simple cleaning procerdure (98% flow-recovery with three successive backwashing sequences) successfully reduced the frequency of requirement of labor-intensive replacement of the whole filter media. Raw water with arsenic …

The Development And Management Of A Primary Care Research Network, 1978-87, Donald Iverson, B Calonge, R Miller, L Niebauer, F Reed

Don C. Iverson

The Ambulatory Sentinel Practice Network (ASPN) was created to increase the knowledge of primary care. Building on the experiences of other national and regional primary care research networks, ASPN has evolved as a North American network including practices in 25 U.S. states and four Canadian provinces in 1987. This paper summarizes ASPN's growth and development since 1978, the involvement of the ASPN practices, and the mechanisms used in developing and managing studies.

Defining Research Priorities For Pancreatic Cancer In Australia: Results Of A Consensus Development Process, Monica Robotin, Sandra Jones, Andrew Biankin, Louise Waters, Donald Iverson, Helen Gooden, Bruce Barraclough, Andrew Penman

Don C. Iverson

Introduction: Pancreatic cancer (PC) is the sixth leading cause of cancer death in Australia and the fourth in the United States, yet research in PC is lagging behind that in other cancers associated with a high disease burden. In the absence of agreed processes to reliably identify research areas which can deliver significant advances in PC research, the Cancer Council NSW established a strategic partnership with the NSW Pancreatic Cancer Network to define critical research issues and opportunities that could accelerate progress in this field in Australia. Materials and methods: The process consisted of five distinct stages: a literature review …

Guanosine Diphosphatase Is Required For Protein And Sphingolipid Glycosylation In The Golgi Lumen Of Saccharomyces Cerevisiae, Claudia Abeijon, Ken Yanagisawa, Elisabet Mandon, Alex Hausler, Kelley Moremen, Carlos Hirschberg, Phillips Robbins

Elisabet Mandon

Current models for nucleotide sugar use in the Golgi apparatus predict a critical role for the lumenal nucleoside diphosphatase. After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol. To test this model, we cloned the gene for the S. cerevisiae guanosine diphosphatase and constructed a null mutation. This mutation should reduce the concentrations of GDP-mannose and GMP and increase the concentration of GDP in the Golgi lumen. The alterations should in turn …

Do Larval Traits Re-Evolve? Evidence From The Embryogenesis Of A Direct-Developing Salamander, Plethodon Cinereus, Ryan Kerney, David Blackburn, Hendrik Muller, James Hanken

Ryan Kerney

Recent molecular phylogenies suggest the surprising reacquisition of posthatching metamorphosis within an otherwise directdeveloping clade of lungless salamanders (family Plethodontidae). Metamorphosis was long regarded as plesiomorphic for plethodontids, yet the genus Desmognathus, which primarily includes metamorphosing species, is now nested within a much larger clade of direct-developing species. The extent to which the putative reacquisition of metamorphosis in Desmognathus represents a true evolutionary reversal is contingent upon the extent to which both larva-specific features and metamorphosis were actually lost during the evolution of direct development. In this study we analyze development of the hyobranchial skeleton, which is dramatically remodeled during …

A Novel Taulacz Allele Reveals A Requirement For Pitx2 In Formation Of The Mammillothalamic Tract, Mindy Waite

Mindy Waite

Distinct Populations Of Gabaergic Neurons In Mouse Rhombomere 1 Express But Do Not Require The Homeodomain Transcription Factor Pitx2, Mindy Waite

Mindy Waite