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A Zebrafish Unc-45-Related Gene Expressed During Muscle Development, Letitiah Etheridge, Philip Diiorio, Charles Sagerstrom
A Zebrafish Unc-45-Related Gene Expressed During Muscle Development, Letitiah Etheridge, Philip Diiorio, Charles Sagerstrom
Philip J diIorio Jr
We report the isolation and expression pattern of zebrafish unc45r, a gene related to Caenorhabditis elegans unc-45. UNC-45 is a muscle-specific protein thought to interact with myosin and promote the assembly of muscle thick filaments during C. elegans development. Zebrafish Unc45r shares sequence features with C. elegans UNC-45, including three tetratricopeptide repeats and a CRO1/She4p homology domain. unc45r is expressed in mesoderm adjacent to the dorsal midline during late gastrula stages and is coexpressed with muscle specific genes in somitic mesoderm during development of trunk skeletal muscle. unc45r is also expressed in cranial skeletal muscle as well as in cardiac …