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Articles 1 - 30 of 37
Full-Text Articles in Life Sciences
Dynamic Adaptation Of Liver Mitochondria To Chronic Alcohol Feeding In Mice: Biogenesis, Remodeling, And Functional Alterations, Derick Han, Maria Ybanez, Heather Johnson, Janiece Mcdonald, Lusine Mesropyan, Harsh Sancheti, Gary Martin, Alanna Martin, Atalie Lim, Lily Dara, Enrique Cadenas, Hidekazu Tsukamoto, Niel Kaplowitz
Dynamic Adaptation Of Liver Mitochondria To Chronic Alcohol Feeding In Mice: Biogenesis, Remodeling, And Functional Alterations, Derick Han, Maria Ybanez, Heather Johnson, Janiece Mcdonald, Lusine Mesropyan, Harsh Sancheti, Gary Martin, Alanna Martin, Atalie Lim, Lily Dara, Enrique Cadenas, Hidekazu Tsukamoto, Niel Kaplowitz
Gary Martin
Liver mitochondria undergo dynamic alterations following chronic alcohol feeding to mice. Intragastric alcohol feeding to mice resulted in 1) increased state III respiration (109% compared with control) in isolated liver mitochondria, probably due to increased levels of complexes I, IV, and V being incorporated into the respiratory chain; 2) increased mitochondrial NAD+ and NADH levels (∼2-fold), with no change in the redox status; 3) alteration in mitochondrial morphology, with increased numbers of elongated mitochondria; and 4) enhanced mitochondrial biogenesis in the liver, which corresponded with an up-regulation of PGC-1α (peroxisome proliferator-activated receptor γ coactivator-1α). Oral alcohol feeding to mice, which …
The Doublecortin-Related Gene Zyg-8 Is A Microtubule Organizer In Caenorhabditis Elegans Neurons, Jean Bellanger, Juan Cueva, Renee Baran, Garland Tang, Miriam Goodman, Anne Debant
The Doublecortin-Related Gene Zyg-8 Is A Microtubule Organizer In Caenorhabditis Elegans Neurons, Jean Bellanger, Juan Cueva, Renee Baran, Garland Tang, Miriam Goodman, Anne Debant
Renee Baran
Doublecortin-domain containing (DCDC) genes play key roles in the normal and pathological development of the human brain cortex. The origin of the cellular specialisation and the functional redundancy of these microtubule (MT)-associated proteins (MAPs), especially those of Doublecortin (DCX) and Doublecortin-like kinase (DCLKs) genes, is still unclear. The DCX domain has the ability to control MT architecture and bundling. However, the physiological significance of such properties is not fully understood. To address these issues, we sought post-mitotic roles for zyg-8, the sole representative of the DCX–DCLK subfamily of genes in C. elegans. Previously, zyg-8 has been shown to control anaphase-spindle …
Catalogue Of Type Material In The Entomological Collection Of The University Of La Laguna (Canary Islands). I – Arachnida, Ana Reboleira, Antonio Pérez, Nuria Macías-Hernandez, Heriberto López, S. De La Cruz, Pedro Oromí
Catalogue Of Type Material In The Entomological Collection Of The University Of La Laguna (Canary Islands). I – Arachnida, Ana Reboleira, Antonio Pérez, Nuria Macías-Hernandez, Heriberto López, S. De La Cruz, Pedro Oromí
Ana Sofia P.S. Reboleira
A catalogue of arachnid type specimens of the collection kept at the Department of Animal Biology, University of La Laguna (Spain) is presented. It harbours type material of 104 species belonging to 23 families of arachnids, represented by 21 holotypes and 164 paratypes for 23 species of pseudoscorpions, and 49 holotypes, 218 paratypes and 3 syntypes for 81 species of spiders. This collection is using the criteria and standards of the Global Biodiversity Information Facility (GBIF) for cataloguing and computerization of the specimens. Type specimens were checked with the original descriptions, and relevant additional information from original labels not included …
Lusoblothrus, A New Syarinid Pseudoscorpion Genus (Arachnida) From Portugal, Occupying An Isolated Position Within The Holarctic Fauna, Ana Reboleira, Juan Zaragoza, Fernando Gonçalves, Pedro Oromí
Lusoblothrus, A New Syarinid Pseudoscorpion Genus (Arachnida) From Portugal, Occupying An Isolated Position Within The Holarctic Fauna, Ana Reboleira, Juan Zaragoza, Fernando Gonçalves, Pedro Oromí
Ana Sofia P.S. Reboleira
The new pseudoscorpion genus Lusoblothrus of the family Syarinidae is described from a cave in the Algarve region, southern Portugal, to accommodate L. aenigmaticus sp. nov., whose morphological affinities within the Holarctic syarinid fauna are not clear and resembles the Gondwanan genera. This discovery emphasizes the relevance of the Algarve region as a hotspot for relictual hypogean fauna within the Iberian Peninsula.
A Phycoerythrin-Specific Bilin Lyase-Isomerase Controls Blue-Green Chromatic Acclimation In Marine Synechococcus., Wendy Schluchter
A Phycoerythrin-Specific Bilin Lyase-Isomerase Controls Blue-Green Chromatic Acclimation In Marine Synechococcus., Wendy Schluchter
Wendy M Schluchter
No abstract provided.
Consumption Of High Ω-3 Fatty Acid Diet Suppressed Prostate Tumorigenesis In C3(1) Tag Mice, Juliana Akinsete, Gabriela Ion, Theodore Witte, W. Hardman
Consumption Of High Ω-3 Fatty Acid Diet Suppressed Prostate Tumorigenesis In C3(1) Tag Mice, Juliana Akinsete, Gabriela Ion, Theodore Witte, W. Hardman
Gabriela Ion
Prostate cancer incidence and mortality are high in the Western world and high ω-6/ω-3 PUFA in the Western diet may be a contributing factor. We investigated whether changing from a diet that approximates ω-6 fat content of the Western diet to a high ω-3 fat diet at adulthood might reduce prostate cancer risk. Female SV 129 mice that had consumed a high ω-6 diet containing corn oil for 2 weeks were bred with homozygous C3(1)Tag transgenic male mice. All male offspring were weaned to the corn oil diet (CO) until postpuberty when half of the male offspring were transferred to …
Phylogenomics And A Posteriori Data Partitioning Resolve The Cretaceous Angiosperm Radiation Malpighiales, Zhenxiang Xi, Brad Ruhfel, Hanno Schaefer, André Amorim, M. Sugumaran, Kenneth Wurdack, Peter Endress, Merran Matthews, Peter Stevens, Sarah Mathews, Charles Davis
Phylogenomics And A Posteriori Data Partitioning Resolve The Cretaceous Angiosperm Radiation Malpighiales, Zhenxiang Xi, Brad Ruhfel, Hanno Schaefer, André Amorim, M. Sugumaran, Kenneth Wurdack, Peter Endress, Merran Matthews, Peter Stevens, Sarah Mathews, Charles Davis
Brad R. Ruhfel
The angiosperm order Malpighiales includes ∼16,000 species and constitutes up to 40% of the understory tree diversity in tropical rain forests. Despite remarkable progress in angiosperm systematics during the last 20 y, relationships within Malpighiales remain poorly resolved, possibly owing to its rapid rise during the mid-Cretaceous. Using phylogenomic approaches, including analyses of 82 plastid genes from 58 species, we identified 12 additional clades in Malpighiales and substantially increased resolution along the backbone. This greatly improved phylogeny revealed a dynamic history of shifts in net diversification rates across Malpighiales, with bursts of diversification noted in the Barbados cherries (Malpighiaceae), cocas …
Simple, Compact Source For Low-Temperature Air Plasmas, D. Sheehan, J. Lawson, M. Sosa, Richard Long
Simple, Compact Source For Low-Temperature Air Plasmas, D. Sheehan, J. Lawson, M. Sosa, Richard Long
Richard A. Long
A simple, compact source of low-temperature, spatially and temporally uniform air plasma using a Telsa induction coil driver is described. The low-power ionization discharge plasma is localized (2 cm X 0.5 cm X 0.1 cm) and essentially free of arc channels. A Teflon coated rolling cylindrical electrode and dielectric coated ground plate are essential to the source’s operation and allow flat test samples to be readily exposed to the plasma. The plasma is a copious source of ozone and nitrogen oxides. Its effects on various microbes are discussed.
Dental Enamel As A Dietary Indicator In Mammals, Peter Lucas, Paul Constantino, Bernard Wood, Brian Lawn
Dental Enamel As A Dietary Indicator In Mammals, Peter Lucas, Paul Constantino, Bernard Wood, Brian Lawn
Paul J. Constantino
The considerable variation in shape, size, structure and properties of the enamel cap covering mammalian teeth is a topic of great evolutionary interest. No existing theories explain how such variations might be fit for the purpose of breaking food particles down. Borrowing from engineering materials science, we use principles of fracture and deformation of solids to provide a quantitative account ofhowmammalian enamelmay be adapted to diet. Particular attention is paid to mammals that feed on ‘hard objects’ such as seeds and dry fruits, the outer casings of which appear to have evolved structures with properties similar to those of enamel. …
Adaptation To Hard-Object Feeding In Sea Otters And Hominins, Paul Constantino, James Lee, Dylan Morris, Peter Lucas, Adam Hartstone-Rose, Wah-Keat Lee, Nathaniel Dominy, Andrew Cunningham, Mark Wagner, Brian Lawn
Adaptation To Hard-Object Feeding In Sea Otters And Hominins, Paul Constantino, James Lee, Dylan Morris, Peter Lucas, Adam Hartstone-Rose, Wah-Keat Lee, Nathaniel Dominy, Andrew Cunningham, Mark Wagner, Brian Lawn
Paul J. Constantino
The large, bunodont postcanine teeth in living sea otters (Enhydra lutris) have been likened to those of certain fossil hominins, particularly the ’robust’ australopiths (genus Paranthropus). We examine this evolutionary convergence by conducting fracture experiments on extracted molar teeth of sea otters and modern humans (Homo sapiens) to determine how load-bearing capacity relates to tooth morphology and enamel material properties. In situ optical microscopy and x-ray imaging during simulated occlusal loading reveal the nature of the fracture patterns. Explicit fracture relations are used to analyze the data and to extrapolate the results from humans to earlier hominins. It is shown …
Fracture Susceptibility Of Worn Teeth, Amanda Keown, Mark Bush, James Lee, Chris Ford, Paul Constantino, Brian Lawn
Fracture Susceptibility Of Worn Teeth, Amanda Keown, Mark Bush, James Lee, Chris Ford, Paul Constantino, Brian Lawn
Paul J. Constantino
An experimental simulation study is made to determine the effects of occlusal wear on the capacity of teeth to resist fracture. Tests are carried out on model dome structures, using glass shells to represent enamel and epoxy filler to represent dentin. The top of the domes are ground and polished to produce flat surfaces of prescribed depths relative to shell thickness. The worn surfaces are then loaded axially with a hard sphere, or a hard or soft flat indenter, to represent extremes of food contacts. The loads required to drive longitudinal cracks around the side walls of the enamel to …
Properties Of Tooth Enamel In Great Apes, Paul Constantino, Brian Lawn, James Lee, Peter Lucas, Dylan Morris, Tanya Smith
Properties Of Tooth Enamel In Great Apes, Paul Constantino, Brian Lawn, James Lee, Peter Lucas, Dylan Morris, Tanya Smith
Paul J. Constantino
A comparative study has been made of human and great ape molar tooth enamel. Nanoindentation techniques are used to map profiles of elastic modulus and hardness across sections from the enamel–dentin junction to the outer tooth surface. The measured data profiles overlap between species, suggesting a degree of commonality in material properties. Using established deformation and fracture relations, critical loads to produce function-threatening damage in the enamel of each species are calculated for characteristic tooth sizes and enamel thicknesses. The results suggest that differences in load-bearing capacity of molar teeth in primates are less a function of underlying material properties …
Global Analysis Of Gene Expression Changes During Retinoic Acid-Induced Growth Arrest And Differentiation Of Melanoma: Comparison To Differentially Expressed Genes In Melanocytes Vs Melanoma, Mary Estler, Goran Boskovic, James Denvir, Sarah Miles, Donald Primerano, Richard Niles
Global Analysis Of Gene Expression Changes During Retinoic Acid-Induced Growth Arrest And Differentiation Of Melanoma: Comparison To Differentially Expressed Genes In Melanocytes Vs Melanoma, Mary Estler, Goran Boskovic, James Denvir, Sarah Miles, Donald Primerano, Richard Niles
James Denvir
BACKGROUND: The incidence of malignant melanoma has significantly increased over the last decade. Some of these malignancies are susceptible to the growth inhibitory and pro-differentiating effects of all-trans-retinoic acid (RA). The molecular changes responsible for the biological activity of RA in melanoma are not well understood. RESULTS: In an analysis of sequential global gene expression changes during a 4-48 h RA treatment of B16 mouse melanoma cells, we found that RA increased the expression of 757 genes and decreased the expression of 737 genes. We also compared the gene expression profile (no RA treatment) between non-malignant melan-a mouse melanocytes and …
Influence Of Genetic Variation In The Fungal Endophyte Of A Grass On An Herbivore And Its Parasitoid, Thomas Bultman, John Rodstrom, Kara Radabaugh, Joshua Vandop, James Librizzi, Leanna Longwell, Christina Pulas, Lashawn Grant, Terrence Sullivan
Influence Of Genetic Variation In The Fungal Endophyte Of A Grass On An Herbivore And Its Parasitoid, Thomas Bultman, John Rodstrom, Kara Radabaugh, Joshua Vandop, James Librizzi, Leanna Longwell, Christina Pulas, Lashawn Grant, Terrence Sullivan
Thomas L. Bultman
Neotyphodium coenophialum (Glenn, Bacon, Price & Hanlin) (Ascomycota: Clavicipitaceae) is an endophytic fungus that lives symbiotically within grasses and produces alkaloids that can help protect its hosts from some insect pests. We used laboratory-based experiments to investigate whether fungal genotype influences an herbivore and its parasitoid. We tested whether variation in novel isolates, plus a control lacking fungal infection, affected preference by fall armyworm, Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae: Amphipyrini), and growth and survival of Euplectrus comstockii Howard (Hymenoptera: Eulophidae: Euplectrini), a parasitoid of fall armyworm. Caterpillars preferred leaf blades in choice experiments from uninfected tall fescue [Lolium arundinaceum (Schreb.) …
A High Omega-3 Fatty Acid Diet Has Different Effects On Early And Late Stage Myeloid Progenitors, Melinda Varney, James Buchanan, Yulia Dementieva, W. Hardman, Vincent Sollars
A High Omega-3 Fatty Acid Diet Has Different Effects On Early And Late Stage Myeloid Progenitors, Melinda Varney, James Buchanan, Yulia Dementieva, W. Hardman, Vincent Sollars
Elaine Hardman Ph.D.
The effects of the polyunsaturated omega-3 (n-3) and omega-6 (n-6) fatty acids (FA) on hematopoiesis are complex in that both FA forms are processed into leukotrienes, eicosanoids, and prostaglandins, which can have independent effects. These FA have antagonistic effects in that n-6 FA prostaglandins tend to be pro-proliferative and pro-inflammatory, while the effects of n-3 FA prostaglandins are the opposite. We have previously shown that diets high in n-3 FA reduce the size of the middle to later stage myeloid progenitor compartment in FVB X sv129 F1hybrid mice. To assay the effects of high n-3 FA diets on earlier stages …
Epigenetic Modification As An Enabling Mechanism For Leukemic Transformation, Vincent Sollars
Epigenetic Modification As An Enabling Mechanism For Leukemic Transformation, Vincent Sollars
Vincent E Sollars
Cancer is now thought of as a fundamentally genetic disease, in that changes in the genome result in aberrant gene expression of oncogenes and tumor suppressor genes to promote oncogenesis. However, with our increasing knowledge of gene regulation, it is becoming obvious that changes in nucleotide sequence are not the sole mechanism for eliciting changes in transcription. An additional layer of regulation of gene expression, called epigenetics, is now being realized as increasingly important in oncogenesis. Epigenetics is defined as non-sequence based changes in chromatin that elicit changes in gene expression that are propagated through mitosis and/or meiosis. The alleles …
Membrane Fusion Proteins Are Required For Oskar Mrna Localization In The Drosophila Egg Chamber, Douglas Ruden, Vincent Sollars, Xiaoyan Wang, Daisuke Mori, Marina Alterman, Xiangyi Lu
Membrane Fusion Proteins Are Required For Oskar Mrna Localization In The Drosophila Egg Chamber, Douglas Ruden, Vincent Sollars, Xiaoyan Wang, Daisuke Mori, Marina Alterman, Xiangyi Lu
Vincent E Sollars
We used a genetic screen in Drosophila to identify mutations which disrupt the localization of oskar mRNA during oogenesis. Based on the hypothesis that some cytoskeletal components which are required during the mitotic divisions will also be required for oskar mRNA localization during oogenesis, we designed the following genetic screen. We screened for P-element insertions in genes which slow down the blastoderm mitotic divisions. A secondary genetic screen was to generate female germ-line clones of these potential cell division cycle genes and to identify those which cause the mislocalization of oskar mRNA. We identified mutations in ter94 which disrupt the …
Diversity In Secreted Pla2-Iia Activity Among Inbred Mouse Strains That Are Resistant Or Susceptible To Apcmin/+ Tumorigenesis, Marina Markova, Revati Koratkar, Karen Silverman, Vincent Sollars, Melina Macphee-Pellini, Rhonda Walters, Juan Palazzo, Arthur Buchberg, Linda Siracusa, Steven Farber
Diversity In Secreted Pla2-Iia Activity Among Inbred Mouse Strains That Are Resistant Or Susceptible To Apcmin/+ Tumorigenesis, Marina Markova, Revati Koratkar, Karen Silverman, Vincent Sollars, Melina Macphee-Pellini, Rhonda Walters, Juan Palazzo, Arthur Buchberg, Linda Siracusa, Steven Farber
Vincent E Sollars
The secreted phospholipase A2 type IIA (Pla2g2a) gene was previously identified as a modifier of intestinal adenoma multiplicity in ApcMin/+ mice. To determine if intestinal secreted phospholipase A2 (sPLA2) activity was also attenuated in susceptible strains, we developed a sensitive assay to directly quantitate sPLA2 activity in the murine intestinal tract utilizing a fluorescent BODIPY-labeled phospholipid substrate. Here, we report assay conditions that distinguish between secreted and cytosolic PLA2 enzyme activities in extracts of intestinal tissue. The small intestine exhibited higher activity levels than the large intestine. Consistent with predictions from the sPLA …
A Drosophila Kinesin-Like Protein, Klp38b, Functions During Meiosis, Mitosis, And Segmentation, Douglas Ruden, Wei Cui, Vincent Sollars, Marina Alterman
A Drosophila Kinesin-Like Protein, Klp38b, Functions During Meiosis, Mitosis, And Segmentation, Douglas Ruden, Wei Cui, Vincent Sollars, Marina Alterman
Vincent E Sollars
We show that klp38B, isolated as a mutation that dominantly prolongs blastoderm mitotic cycles in Drosophila, encodes a Drosophila kinesin-like protein. Further genetic analyses show that Klp38B not only functions during mitosis, but is also required for meiosis and abdominal segmentation. Sequence comparisons suggest that Klp38B encodes an aminoterminal microtubule motor domain, a central a-helical coiled-coil domain, and a C-terminal globular domain. Evidence that Klp38B is required during meiosis is that flies transheterozygous for mutations in both klp38B and nod have a high frequency of 4th chromosome meiotic nondisjunction. Nod is a chromokinesin, a chromosome binding kinesin, that is believed …
17-N-Allylamino-17-Demethoxygeldanamycin Induces A Diverse Response In Human Acute Myelogenous Cells, Jennifer Napper, Vincent Sollars
17-N-Allylamino-17-Demethoxygeldanamycin Induces A Diverse Response In Human Acute Myelogenous Cells, Jennifer Napper, Vincent Sollars
Vincent E Sollars
The goal of this study was to ascertain the specific effects of 17-N-Allylamino-17-demethoxygeldanamycin (17-AAG) treatment in human acute myelogenous leukemia (AML). Four human leukemia cell lines were treated with varying doses of 17-AAG followed by analysis of toxicity, apoptosis, proliferation, and cell cycle. Cell cycle analysis revealed that the cells accumulate in G2/M phase within 96 hours of treatment, although the effect was not equivalent among the cell lines. p21, p53 expression and MDR1 activity were among the possible mechanisms uncovered for the differing responses. Exploiting these differences may allow for more effective combinatory treatments in patients with AML.
A High Omega-3 Fatty Acid Diet Has Different Effects On Early And Late Stage Myeloid Progenitors, Melinda Varney, James Buchanan, Yulia Dementieva, W. Hardman, Vincent Sollars
A High Omega-3 Fatty Acid Diet Has Different Effects On Early And Late Stage Myeloid Progenitors, Melinda Varney, James Buchanan, Yulia Dementieva, W. Hardman, Vincent Sollars
Vincent E Sollars
The effects of the polyunsaturated omega-3 (n-3) and omega-6 (n-6) fatty acids (FA) on hematopoiesis are complex in that both FA forms are processed into leukotrienes, eicosanoids, and prostaglandins, which can have independent effects. These FA have antagonistic effects in that n-6 FA prostaglandins tend to be pro-proliferative and pro-inflammatory, while the effects of n-3 FA prostaglandins are the opposite. We have previously shown that diets high in n-3 FA reduce the size of the middle to later stage myeloid progenitor compartment in FVB X sv129 F1hybrid mice. To assay the effects of high n-3 FA diets on earlier stages …
Discordant Timing Between Antennae Disrupts Sun Compass Orientation In Migratory Monarch Butterflies, Robert Gegear, Patrick Guerra, Christine Merlin, Steven Reppert
Discordant Timing Between Antennae Disrupts Sun Compass Orientation In Migratory Monarch Butterflies, Robert Gegear, Patrick Guerra, Christine Merlin, Steven Reppert
Robert J. Gegear
To navigate during their long-distance migration, monarch butterflies (Danaus plexippus) use a time-compensated sun compass. The sun compass timing elements reside in light-entrained circadian clocks in the antennae. Here we show that either antenna is sufficient for proper time compensation. However, migrants with either antenna painted black (to block light entrainment) and the other painted clear (to permit light entrainment) display disoriented group flight. Remarkably, when the black-painted antenna is removed, re-flown migrants with a single, clear-painted antenna exhibit proper orientation behaviour. Molecular correlates of clock function reveal that period and timeless expression is highly rhythmic in brains and clear-painted …
Star Rna-Binding Protein Quaking Suppresses Cancer Via Stabilization Of Specific Mirna, Natalie Farny, An-Jou Chen, Ji-Hye Paik, Hailei Zhang, Sachet Shukla, Richard Mortensen, Jian Hu, Haoqiang Ying, Baoli Hu, Jessica Hurt, Caroline Dong, Yonghong Xiao, Y. Wang, Pamela Silver, Lynda Chin, Shobha Vasudevan, Ronald Depinho
Star Rna-Binding Protein Quaking Suppresses Cancer Via Stabilization Of Specific Mirna, Natalie Farny, An-Jou Chen, Ji-Hye Paik, Hailei Zhang, Sachet Shukla, Richard Mortensen, Jian Hu, Haoqiang Ying, Baoli Hu, Jessica Hurt, Caroline Dong, Yonghong Xiao, Y. Wang, Pamela Silver, Lynda Chin, Shobha Vasudevan, Ronald Depinho
Natalie G. Farny
Multidimensional cancer genome analysis and validation has defined Quaking (QKI), a member of the signal transduction and activation of RNA (STAR) family of RNA-binding proteins, as a novel glioblastoma multiforme (GBM) tumor suppressor. Here, we establish that p53 directly regulates QKI gene expression, and QKI protein associates with and leads to the stabilization of miR-20a; miR-20a, in turn, regulates TGFβR2 and the TGFβ signaling network. This pathway circuitry is substantiated by in silico epistasis analysis of its components in the human GBM TCGA (The Cancer Genome Atlas Project) collection and by their gain- and loss-of-function interactions in in vitro and …
Comparing Volunteer And Professionally Collected Monitoring Data From The Rocky Subtidal Reefs Of Southern California, Usa, David Gillett, Daniel Pondella, Jan Freiwald, Kenneth Schiff, Jennifer Caselle, Craig Shuman, Stephen Weisberg
Comparing Volunteer And Professionally Collected Monitoring Data From The Rocky Subtidal Reefs Of Southern California, Usa, David Gillett, Daniel Pondella, Jan Freiwald, Kenneth Schiff, Jennifer Caselle, Craig Shuman, Stephen Weisberg
Daniel Pondella
Volunteer-based citizen monitoring has increasingly become part of the natural resources monitoring framework, but it is often unclear whether the data quality from these programs is sufficient for integration with traditional efforts conducted by professional scientists. At present, the biological and physical characteristics of California’s rocky reef kelp forests are concurrently monitored by two such groups, using similar methodologies—underwater visual census (UVC) of fish, benthic invertebrates, and reef habitat, though the volunteer group limits their sampling to transects close to the reef surface and they use a more constrained list of species for enumeration and measurement. Here, we compared the …
Association Between Prostate Cancer In Black Americans And An Allele Of The Padprp Pseudogene Locus On Chromosome 13, Helen Donis-Keller, Jennifer Doll, B Suarez
Association Between Prostate Cancer In Black Americans And An Allele Of The Padprp Pseudogene Locus On Chromosome 13, Helen Donis-Keller, Jennifer Doll, B Suarez
Helen Donis-Keller
Black American men have a higher incidence of cancer of the prostate (CAP), multiple myeloma, and lung cancer than do white American men (discussed by Lyn et al.1993a). The basis for these differences no doubt includes environmental influences, because American blacks have also been found to have a higher incidence of CAP than do African blacks. However, genetic factors may play a role as well. For example, Lyn et al. (1993a) reported an increase in the frequency of an allele of the poly(ADPribose)polymerase (PADPRP) pseudogene locus onchromosome 13 in black Americans with CAP, suggesting the presence of a disease-susceptibility locus. …
Genetic Analysis Of Prostatic Atypical Adenomatous Hyperplasia (Adenosis), Helen Donis-Keller, Jennifer Doll, Xiaopei Zhu, Jaime Furman, Zahid Kaleem, Carlos Torres, Peter Humphrey
Genetic Analysis Of Prostatic Atypical Adenomatous Hyperplasia (Adenosis), Helen Donis-Keller, Jennifer Doll, Xiaopei Zhu, Jaime Furman, Zahid Kaleem, Carlos Torres, Peter Humphrey
Helen Donis-Keller
Atypical adenomatous hyperplasia (AAH) of the prostate, a small glandular proliferation, is a putative precursor lesion to prostate cancer, in particular to the subset of well-differentiated carcinomas that arise in the transition zone, the same region where AAH lesions most often occur. Several morphological characteristics of AAH suggest a relationship to cancer; however, no definitive evidence has been reported. In this study, we analyzed DNA from 25 microdissected AAH lesions for allelic imbalance as compared to matched normal DNA, using one marker each from chromosome arms 1q, 6q, 7q, 10q, 13q, 16q, 17p, 17q, and 18q, and 19 markers from …
Hypoxia-Ischemia In The Immature Brain And Mechanisms Of Reducing Tissue Damage, Edgar Lehr, Susan Vannucci, Faculty Advisor, Victoria Simmons, '12
Hypoxia-Ischemia In The Immature Brain And Mechanisms Of Reducing Tissue Damage, Edgar Lehr, Susan Vannucci, Faculty Advisor, Victoria Simmons, '12
Edgar Lehr
No abstract provided.
A New Species Of Frog (Strabomantidae: Pristimantis) From Peru With Comments On Its Ectoparasites (Acari: Trombiculidae), Edgar Lehr, Alan Brus, '12
A New Species Of Frog (Strabomantidae: Pristimantis) From Peru With Comments On Its Ectoparasites (Acari: Trombiculidae), Edgar Lehr, Alan Brus, '12
Edgar Lehr
No abstract provided.
Interaction Of Fish Aryl Hydrocarbon Receptor Paralogs (Ahr1 And Ahr2) With The Retinoblastoma Protein, Rebeka Merson, Sibel Karchner, Mark Hahn
Interaction Of Fish Aryl Hydrocarbon Receptor Paralogs (Ahr1 And Ahr2) With The Retinoblastoma Protein, Rebeka Merson, Sibel Karchner, Mark Hahn
Rebeka Rand Merson
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) and related compounds. In some mammalian cell lines, TCDD induces G1 cell cycle arrest, which depends on an interaction between the AHR and the retinoblastoma tumor suppressor (RB). Mammals possess one AHR, whereas fishes possess two or more AHR paralogs that differ in the domains important for AHR-RB interactions in mammals. To test the hypothesis that fish AHR paralogs differ in their ability to interact with RB, we cloned RB cDNA from Atlantic killifish, Fundulus heteroclitus, and studied the interactions of killifish RB protein with killifish AHR1 and …
Squamatinia Algharbica Gen. N. Sp. N., A Remarkable New Coletiniinae Silverfish (Zygentoma: Nicoletiidae) From Caves In Southern Portugal, Ana Reboleira, Fernando Gonçalves, Pedro Oromí, Luís Mendes
Squamatinia Algharbica Gen. N. Sp. N., A Remarkable New Coletiniinae Silverfish (Zygentoma: Nicoletiidae) From Caves In Southern Portugal, Ana Reboleira, Fernando Gonçalves, Pedro Oromí, Luís Mendes
Ana Sofia P.S. Reboleira
A new genus of Coletiniinae silverfish (Nicoletiidae) similar to Coletinia Wygodzinsky and Lepidospora Escherich is described to accommodate the new species Squamatinia algharbica gen. n. sp. n. Many individuals were collected over all seasons of the year in four caves of the Algarve karst massif in the south of Portugal. An identification key for the known genera of Coletiniinae is provided, as well as some biogeographical and ecological comments.