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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Design And Synthesis Of Carbohydrate Based Derivatives As Antimicrobial Compounds, Aoife Smith
Design And Synthesis Of Carbohydrate Based Derivatives As Antimicrobial Compounds, Aoife Smith
Doctoral
Investigations into the design of analogues of GlcNAc-Ins, the substrate for the enzyme GlcNAc-Ins deacetylase (mshB), a therapeutic target on the pathway to mycothiol biosynthesis in Mycobacterium tuberculosis are described. Initial studies directed towards the design of a substrate analogue were based on the 3-D structure and a proposed mechanism of action of mshB (deduced by Dr. Andrew McCarthy, EMBL). The compounds were designed with the aim to produce an analogue which could better mimic the natural substrate for mshB (GlcNAc-Ins) for crystallisation and mechanistic studies to further improve the knowledge of this enzyme. A series of fatty acid ester …
An Investigation Of The Diets Of Infants Born In Ireland During The First Six Months Of Life, Roslyn Tarrant
An Investigation Of The Diets Of Infants Born In Ireland During The First Six Months Of Life, Roslyn Tarrant
Doctoral
Appropriate infant feeding practices play a crucial part in achieving optimal health outcomes. It is well established that the protection, promotion and support of exclusive breastfeeding during the first 6-months of life would decrease the health inequalities experienced by mothers and infants (WHO/UNICEF, 2003c). Optimal weaning practices also have significant implications for infant health, notably in relation to normal development, mineral balance and the development of obesity (Department of Health, 1994). Historically, Ireland has one of the lowest breastfeeding rates in Europe. Furthermore, prior Irish-based research indicates significant deficiencies relating to weaning practices among mothers during the first year of …
Combination Of Natural Variability Estimation With Real Time Measurement For Mushroom Shelf Life Assessment., Leixuri Aguirre
Combination Of Natural Variability Estimation With Real Time Measurement For Mushroom Shelf Life Assessment., Leixuri Aguirre
Doctoral
The shelf life of mushrooms (Agaricus bisporus) is affected by the natural variability of the produce which influences the perishable vegetable quality. One of the main causes of this variability is non-homogeneity in the product maturity at harvest, resulting in each vegetable batch being at a different stage of senescence. The present work aims to study a new approach to improve the assessment of the shelf life of mushrooms (Agaricus bisporus) taking into account this variability. The study of variability involved the: i) study of the shelf life, quality parameters and variability of the mushrooms and modelling these experimental laboratory …
Poverty, Diet And Health Behaviours: A Quantitative And Qualitative Study Among Young Urbanised Women., Daniel Mccartney
Poverty, Diet And Health Behaviours: A Quantitative And Qualitative Study Among Young Urbanised Women., Daniel Mccartney
Doctoral
Demographic, socio-economic, attitudinal, dietary, health behavioural and anthropometric data were collected from 221 “disadvantaged” and 74 “advantaged” women aged 18-35 years across Dublin, according to the provisions of a novel socio-economic sampling frame. Internal and external validation techniques established the dietary assessment method of choice and identified “valid” dietary reporters (n=216, 153 disadvantaged, 63 advantaged) among this sample. Five qualitative focus groups (n=5-8 per group) were also conducted among disadvantaged women to examine their diet and health behaviour choices. Lower intakes of fruit and vegetables (172g/d vs. 405g/d, p
Evaluation Of Regulation Of Late Gene Expression In Human Papillomavirus-Infected Cervical Epithelia, Joanna Fay
Evaluation Of Regulation Of Late Gene Expression In Human Papillomavirus-Infected Cervical Epithelia, Joanna Fay
Doctoral
Cervical cancer is second only to breast cancer as the most common cancer among women worldwide and is caused by Human Papillomavirus (HPV). The aim of this study was to evaluate the role of RNA-binding proteins in the expression of HPV in cervical cells and clinical samples. Firstly, an audit was performed on cervical biopsy samples taken by laser loop excision over 5 years in the National Maternity Hospital, Holles Street, Dublin, Ireland. The presence of HPV and HPV-16 was evaluated on fifty of these samples and the distribution of multiple RNA-binding proteins, including SR proteins and hnRNPs, was evaluated …